Carotid atherosclerosis in elderly hypertensive patients: potential role of endothelin and plasma antioxidant capacity

Introduction: Elevated lipid levels are associated with the subsequent development of hypertension. However, the role of dyslipidemia in hypertension in the elderly has received little attention. Aim: We evaluated dyslipidemia in newly diagnosed elderly hypertensive patients at Dr RPGMC Kangra at Tanda. Methods: One hundred patients above 60 year of age newly diagnosed with hypertension and presenting to outpatient clinic of Department of Medicine, Dr RPGMC Kangra were included. Statistical analysis was performed using SPSS v21.0 (IBM, USA). Results: Mean age of the patients was 70.9±6.8 years. 52% were males, 61% were taking vegetarian diet, 33% were smokers, 23% were abusing alcohol, and 19% were diabetic. Mean BMI was 23.6±2.4 Kg/m2. 25% had hypercholesterolemia (>230 mg/dl), 22% had triglyceridemia (>160 mg/dl), and 22% had LDL levels more than 120 mg/dl. In this study, non-vegetarian diet and diabetes were significantly associated with increased levels of cholesterol and triglycerides while only diabetes was a risk factors for increased LDL. Dyslipidemias were not associated with abnormal findings on ECG and Echo. Conclusion: Non-vegeterian diet and presence of diabetes are risk factors of dyslipidemia among the newly diagnosed elderly patients with hypertension.

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The Role of Ambulatory Blood Pressure Monitoring in Elderly Hypertensive Patients

Blood Pressure ◽

10.1080/713782692 ◽

2000 ◽

Vol 9 (4) ◽

pp. 12-16 ◽

Cited By ~ 8

Author(s):

Giuseppe Mancia ◽

Gianfranco Parati

Keyword(s):

Blood Pressure ◽

Ambulatory Blood Pressure Monitoring ◽

Ambulatory Blood Pressure ◽

Blood Pressure Monitoring ◽

Pressure Monitoring ◽

Hypertensive Patients ◽

Elderly Hypertensive ◽

Elderly Hypertensive Patients

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Increased antioxidant capacity in the plasma of dogs after a single oral dosage of tocotrienols

British Journal Of Nutrition ◽

10.1017/s0007114511000511 ◽

2011 ◽

Vol 106 (S1) ◽

pp. S116-S119 ◽

Cited By ~ 2

Author(s):

Jens Raila ◽

Sascha Rohn ◽

Florian J. Schweigert ◽

Getu Abraham

Keyword(s):

Antioxidant Capacity ◽

Oral Dosage ◽

Trolox Equivalent Antioxidant Capacity ◽

Total Plasma ◽

Beagle Dogs ◽

Plasma Antioxidant Capacity ◽

Trolox Equivalent ◽

Plasma Antioxidant ◽

Time Point

The intestinal absorption of tocotrienols (TCT) in dogs is, to our knowledge, so far unknown. Adult Beagle dogs (n 8) were administered a single oral dosage of a TCT-rich fraction (TRF; 40 mg/kg body weight) containing 32 % α-TCT, 2 % β-TCT, 27 % γ-TCT, 14 % δ-TCT and 25 % α-tocopherol (α-TCP). Blood was sampled at baseline (fasted), 1, 2, 3, 4, 5, 6, 8 and 12 h after supplementation. Plasma and chylomicron concentrations of TCT and α-TCP were measured at each time point. Plasma TAG were measured enzymatically, and plasma antioxidant capacity was assessed by the Trolox equivalent antioxidant capacity assay. In fasted dogs, levels of TCT were 0·07 (sd 0·03) μmol/l. Following the administration of the TRF, total plasma TCT peaked at 2 h (7·16 (sd 3·88) μmol/l; P < 0·01) and remained above baseline levels (0·67 (sd 0·44) μmol/l; P < 0·01) at 12 h. The TCT response in chylomicrons paralleled the increase in TCT in plasma with a maximum peak (3·49 (sd 2·06) μmol/l; P < 0·01) at 2 h post-dosage. α-TCP was the major vitamin E detected in plasma and unaffected by TRF supplementation. The Trolox equivalent values increased from 2 h (776 (sd 51·2) μmol/l) to a maximum at 12 h (1130 (sd 7·72) μmol/l; P < 0·01). The results show that TCT are detected in postprandial plasma of dogs. The increase in antioxidant capacity suggests a potential beneficial role of TCT supplementation in the prevention or treatment of several diseases in dogs.

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