scholarly journals Increased antioxidant capacity in the plasma of dogs after a single oral dosage of tocotrienols

2011 ◽  
Vol 106 (S1) ◽  
pp. S116-S119 ◽  
Author(s):  
Jens Raila ◽  
Sascha Rohn ◽  
Florian J. Schweigert ◽  
Getu Abraham
Keyword(s):  
Antioxidant Capacity ◽  
Oral Dosage ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Total Plasma ◽  
Beagle Dogs ◽  
Plasma Antioxidant Capacity ◽  
Trolox Equivalent ◽  
Plasma Antioxidant ◽  
Time Point

The intestinal absorption of tocotrienols (TCT) in dogs is, to our knowledge, so far unknown. Adult Beagle dogs (n 8) were administered a single oral dosage of a TCT-rich fraction (TRF; 40 mg/kg body weight) containing 32 % α-TCT, 2 % β-TCT, 27 % γ-TCT, 14 % δ-TCT and 25 % α-tocopherol (α-TCP). Blood was sampled at baseline (fasted), 1, 2, 3, 4, 5, 6, 8 and 12 h after supplementation. Plasma and chylomicron concentrations of TCT and α-TCP were measured at each time point. Plasma TAG were measured enzymatically, and plasma antioxidant capacity was assessed by the Trolox equivalent antioxidant capacity assay. In fasted dogs, levels of TCT were 0·07 (sd 0·03) μmol/l. Following the administration of the TRF, total plasma TCT peaked at 2 h (7·16 (sd 3·88) μmol/l; P < 0·01) and remained above baseline levels (0·67 (sd 0·44) μmol/l; P < 0·01) at 12 h. The TCT response in chylomicrons paralleled the increase in TCT in plasma with a maximum peak (3·49 (sd 2·06) μmol/l; P < 0·01) at 2 h post-dosage. α-TCP was the major vitamin E detected in plasma and unaffected by TRF supplementation. The Trolox equivalent values increased from 2 h (776 (sd 51·2) μmol/l) to a maximum at 12 h (1130 (sd 7·72) μmol/l; P < 0·01). The results show that TCT are detected in postprandial plasma of dogs. The increase in antioxidant capacity suggests a potential beneficial role of TCT supplementation in the prevention or treatment of several diseases in dogs.

Effect of Propofol, Sevoflurane and Desflurane on Systemic Redox Balance

2007 ◽  
Vol 20 (3) ◽  
pp. 585-593 ◽  
Author(s):  
G. Cinnella ◽  
G. Vendemiale ◽  
M. Dambrosio ◽  
G. Serviddio ◽  
P.L. Pugliese ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Antioxidant Properties ◽  
Redox Balance ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Sodium Thiopental ◽  
Blood Samples ◽  
Plasma Antioxidant Capacity ◽  
Trolox Equivalent ◽  
Plasma Antioxidant ◽  
Group D

We studied the effects of Propofol, Desflurane, and Sevoflurane on the systemic redox balance in patients undergoing laparohysterectomy. We measured blood concentration of glutathione (GSH), plasma antioxidant capacity (Trolox Equivalent Antioxidant Capacity-TEAC), and lipid peroxidation products (malondialdehyde (aMDA) and 4-hydroxynonenal (aHNE) protein adducts). Sixty patients were randomly placed into three groups of twenty people each. In Group P anesthesia was induced with Propofol 2 mg/kg and maintained with 12–10–8 mg/kg/min; in Groups S and D anesthesia was induced with 3 mg/kg Sodium Thiopental and maintained with 2% Sevoflurane and 6% Desflurane, respectively. Blood samples were collected prior to induction (T0bas), 60min and 24h postoperatively (T160' and T224 h). In Group P, GSH increased on T160' (p<0.02) and returned to baseline on T24h, while TEAC remained unmodified; in Groups S, GSH and TEAC decreased on T160' (p<0.01 vs. T0bas, p<0.03 vs. T0bas, respectively); in Group D, on T160' there was a slight decrease of GSH and TEAC. The levels of aMDA slightly decreased throughout the study periods in Group P, increased in Group D, and remained stable in Group S. Propofol showed antioxidant properties, while Sevoflurane and Desflurane seemed to shift the redox balance towards oxidation, yet without inducing overt oxidative damage.

A Novel Method for Measuring Antioxidant Capacity and its Application to Monitoring the Antioxidant Status in Premature Neonates

1993 ◽  
Vol 84 (4) ◽  
pp. 407-412 ◽  
Author(s):  
Nicholas J. Miller ◽  
Catherine Rice-Evans ◽  
Michael J. Davies ◽  
Vimala Gopinathan ◽  
Anthony Milner
Keyword(s):  
Antioxidant Capacity ◽  
Radical Scavenging ◽  
Reference Population ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Antioxidant Compounds ◽  
Automated Method ◽  
Plasma Antioxidant Capacity ◽  
Total Antioxidant ◽  
Trolox Equivalent ◽  
Plasma Antioxidant

1. A new method has been developed for measuring the total antioxidant capacity of body fluids and drug solutions, based on the absorbance of the ABTS*+ radical cation. 2. An automated method for use on a centrifugal analyser, as well as a manual method, is described. 3. The procedure has been applied to physiological antioxidant compounds and radical-scavenging drugs, and an antioxidant ranking was established based on their reactivity relative to a 1.0 mmol/l Trolox standard. 4. The Trolox equivalent antioxidant capacity of plasma from an adult reference population has been measured, and the method optimized and validated. 5. The method has been applied to investigate the total plasma antioxidant capacity of neonates and how this may be compromised in prematurity.

Albumin influences total plasma antioxidant capacity favorably in patients with acute lung injury*

2004 ◽  
Vol 32 (3) ◽  
pp. 755-759 ◽  
Author(s):  
Gregory J. Quinlan ◽  
Sharon Mumby ◽  
Greg S. Martin ◽  
Gordon R. Bernard ◽  
John M. C. Gutteridge ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Antioxidant Capacity ◽  
Total Plasma ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant

scholarly journals Relationship between vitamin intake and total antioxidant capacity in elderly adults

2016 ◽  
Vol 21 (2) ◽  
pp. 167 ◽  
Author(s):  
Miriam Lucia Ojeda Arredondo ◽  
Magda Catalina Pinilla Betancourt ◽  
Martha Lucia Borrero Yoshida ◽  
Gonzalo Sequeda ◽  
Vivian Maritza Castro Herrera ◽  
...  
Keyword(s):  
Vitamin A ◽  
Antioxidant Capacity ◽  
Fruits And Vegetables ◽  
Natural Antioxidants ◽  
Absorption Capacity ◽  
Trolox Equivalent Antioxidant Capacity ◽  
P Value ◽  
Food Composition Tables ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant

<p>The consumption of foods high in natural antioxidants, like fruits and vegetables, is associated with a lower risk of oxidative stress-related diseases. The aim of this study was to establish the relationship between the plasma antioxidant capacity in adults over fifty and their intake of vitamin A, C, and E. We evaluated 118 24-hour recalls of intake of foods. The intake of vitamin A, C, and E was quantified using food composition tables. We quantified plasma phenols using the Folin-Ciocalteu method. The antioxidant capacity was determined using the Trolox Equivalent Antioxidant Capacity (TEAC) and Oxygen Radical Absorption Capacity (ORAC) methods. Correlation analyses were performed between the studied variables and a positive correlation was found in most cases. However, none of the correlations was statistically significant. In all cases p-value was &gt;0.05. The quantification of nutrient intake is not an adequate predictor of plasma antioxidant capacity in individuals over fifty</p>

Total plasma antioxidant capacity is not always decreased in sepsis

1998 ◽  
Vol 26 (4) ◽  
pp. 705-709 ◽  
Author(s):  
Carlos Pascual ◽  
Waheedullah Karzai ◽  
Andreas Meier-Hellmann ◽  
Mathias Oberhoffer ◽  
Anthon Horn ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Total Plasma ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant

scholarly journals Postprandial Effect of Yogurt Enriched with Anthocyanins from Riceberry Rice on Glycemic Response and Antioxidant Capacity in Healthy Adults

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2930
Author(s):  
Tanisa Anuyahong ◽  
Charoonsri Chusak ◽  
Thavaree Thilavech ◽  
Sirichai Adisakwattana
Keyword(s):  
Antioxidant Capacity ◽  
Plasma Glucose ◽  
Healthy Adults ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Subjective Rating ◽  
Glycemic Response ◽  
Subjective Ratings ◽  
Reducing Ability ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant

The pigment of riceberry rice has been reported to contain anthocyanins which act as a free radical scavenger and inhibitor of carbohydrate digestive enzymes. Since the probiotic yogurt incorporated with the pigment of riceberry rice extract was previously developed, the present study was aimed to investigate the acute effect of riceberry rice yogurt consumption on postprandial glycemic response, antioxidant capacity, and subjective ratings in healthy adults. In a cross-over design, 19 healthy participants were randomized to consume 350 g of yogurt supplemented with 0.25% (w/w) riceberry rice extract or the control yogurt. Postprandial plasma glucose, antioxidant status, and subjective ratings were measured at fasting and intervals (0–3 h) after ingestion of yogurt. The primary outcome was glycemic response; the secondary outcomes were plasma antioxidant capacity. In comparison to the yogurt control, riceberry rice yogurt reduced plasma glucose concentration after 30 min of consumption. The incremental area under the curve (iAUC) was significantly lower after riceberry rice yogurt load than after the control yogurt load. The consumption of riceberry yogurt caused an acute increase in plasma ferric reducing ability of plasma (FRAP), Trolox equivalent antioxidant capacity (TEAC), and oxygen radical absorbance capacity (ORAC) from the baseline values after 60 min of 0.25 ± 0.06 mM FeSO4, 253.7 ± 35.5 mM Trolox equivalents, and 166.8 ± 28.9 mM Trolox equivalents, respectively. Furthermore, the iAUCs for FRAP, TEAC, ORAC, and protein thiol were higher in riceberry yogurt consumption compared with the control yogurt (1.6-, 1.6-, 2.9-, and 1.9-fold, respectively). A decrease in iAUC for plasma malondialdehyde (MDA) concentration was also observed in the riceberry yogurt group. However, consumption of riceberry rice yogurt and control yogurt showed similar subjective rating scores of hunger, desire to eat, fullness, and satiety. In conclusion, acute consumption of riceberry rice yogurt suppressed postprandial glucose level and improved plasma antioxidant capacity in healthy volunteers.

Role of exercise and ascorbate on plasma antioxidant capacity in thoroughbred race horses

2001 ◽  
Vol 128 (1) ◽  
pp. 99-104 ◽  
Author(s):  
Allan White ◽  
Manuel Estrada ◽  
Katherine Walker ◽  
Pamela Wisnia ◽  
Gonzalo Filgueira ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Plasma Antioxidant Capacity ◽  
Plasma Antioxidant ◽  
Race Horses
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