scholarly journals Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma

2011 ◽  
Vol 25 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Satyendra Chandra Tripathi ◽  
Jatinder Kaur ◽  
Ajay Matta ◽  
Xin Gao ◽  
Bin Sun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor

scholarly journals Calreticulin is a novel independent prognostic factor for oral squamous cell carcinoma

2017 ◽  
Vol 13 (6) ◽  
pp. 4857-4862 ◽  
Author(s):  
Koji Harada ◽  
Takanori Takenawa ◽  
Tarannum Ferdous ◽  
Yasuhiro Kuramitsu ◽  
Yoshiya Ueyama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor

Tumor Budding Is an Independent Prognostic Factor for Prediction of Lymph Node Metastasis in Oral Squamous Cell Carcinoma

2015 ◽  
Vol 23 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Punnya V. Angadi ◽  
Prakash V. Patil ◽  
Kaveri Hallikeri ◽  
M. D. Mallapur ◽  
Seema Hallikerimath ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Tumor Budding ◽  
Node Metastasis

scholarly journals Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 653
Author(s):  
Paloma Lequerica-Fernández ◽  
Julián Suárez-Canto ◽  
Tania Rodriguez-Santamarta ◽  
Juan Pablo Rodrigo ◽  
Faustino Julián Suárez-Sánchez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Stem Cell Markers ◽  
Cancer Stem Cell Markers

This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.

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