Prognostic value of clinicopathological parameters and outcome in 484 patients with oral squamous cell carcinoma: microvascular invasion (V+) is an independent prognostic factor for OSCC

2012 ◽  
Vol 14 (11) ◽  
pp. 870-880 ◽  
Author(s):  
M. Grimm
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Microvascular Invasion ◽  
Independent Prognostic Factor ◽  
Clinicopathological Parameters

scholarly journals Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma

2011 ◽  
Vol 25 (1) ◽  
pp. 14-25 ◽  
Author(s):  
Satyendra Chandra Tripathi ◽  
Jatinder Kaur ◽  
Ajay Matta ◽  
Xin Gao ◽  
Bin Sun ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor

scholarly journals Calreticulin is a novel independent prognostic factor for oral squamous cell carcinoma

2017 ◽  
Vol 13 (6) ◽  
pp. 4857-4862 ◽  
Author(s):  
Koji Harada ◽  
Takanori Takenawa ◽  
Tarannum Ferdous ◽  
Yasuhiro Kuramitsu ◽  
Yoshiya Ueyama
Keyword(s):  
Squamous Cell Carcinoma ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor

scholarly journals Prognostic value of tertiary lymphoid structure and tumour infiltrating lymphocytes in oral squamous cell carcinoma

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Qunxing Li ◽  
Xiangqi Liu ◽  
Dikan Wang ◽  
Yanqiong Wang ◽  
Huanzi Lu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
T Cells ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Nk Cells ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Lymphoid Structures ◽  
Infiltrating Lymphocytes

Abstract Tertiary lymphoid structures (TLS) are ectopic lymphoid structures in cancers that are largely associated with favourable prognosis. However, the prognostic value of TLSs in oral squamous cell carcinoma (OSCC) is largely unknown, and the association between tumour infiltrating lymphocytes (TILs) and TLSs has been rarely explored in OSCC. In this study, associated markers of TLS, including peripheral node address (PNAd) in high endothelial venules, CD20 in B cells and CD3 in T cells, were examined in 168 OSCC patients, and survival analysis was performed between TLS-positive and TLS-negative cohorts. We detected the presence of TILs by staining CD8+ cytotoxic T cells and CD57+ NK cells as well. TLSs appeared as highly organized structures in 45 (26.8%) cases. TLS-positive patients had a better 5-year overall survival (OS) rate (88.9% vs. 56.1%, P < 0.001) and relapse-free survival (RFS) rate (88.9% vs. 63.4%, P = 0.002). Moreover, the presence of TLS was an independent prognostic factor for both the 5-year OS rate (hazard ratio [HR] = 3.784; 95% confidence interval [CI], 1.498–9.562) and RFS rate (HR = 3.296; 95% CI, 1.279–8.490) in multivariate analysis. Furthermore, a higher density of CD8+ T cells and CD57+ NK cells was found in TLS-positive sections than in TLS-negative counterparts (P < 0.001), and their combination provided a higher predictive accuracy (AUC = 0.730; 95% CI, 0.654–0.805). In conclusion, our results suggest that TLS is an independent positive prognostic factor for OSCC patients. These findings provide a theoretical basis for the future diagnostic and therapeutic value of TLSs in OSCC treatment.

Tumor Budding Is an Independent Prognostic Factor for Prediction of Lymph Node Metastasis in Oral Squamous Cell Carcinoma

2015 ◽  
Vol 23 (2) ◽  
pp. 102-110 ◽  
Author(s):  
Punnya V. Angadi ◽  
Prakash V. Patil ◽  
Kaveri Hallikeri ◽  
M. D. Mallapur ◽  
Seema Hallikerimath ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Tumor Budding ◽  
Node Metastasis

scholarly journals Prognostic Relevance of CD4+, CD8+ and FOXP3+ TILs in Oral Squamous Cell Carcinoma and Correlations with PD-L1 and Cancer Stem Cell Markers

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 653
Author(s):  
Paloma Lequerica-Fernández ◽  
Julián Suárez-Canto ◽  
Tania Rodriguez-Santamarta ◽  
Juan Pablo Rodrigo ◽  
Faustino Julián Suárez-Sánchez ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Oral Squamous Cell Carcinoma ◽  
Cancer Stem Cell ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Independent Prognostic Factor ◽  
Stem Cell Markers ◽  
Cancer Stem Cell Markers

This study investigates the relevance of tumor-infiltrating lymphocytes (TILs) in oral squamous cell carcinoma (OSCC). Immunohistochemical analysis of stromal/tumoral CD4+, CD8+ and FOXP3+ TILs is performed in 125 OSCC patients. Potential relationships with the expression of tumoral PD-L1 and cancer stem cell (CSC) markers (NANOG, SOX2, OCT4, Nestin and Podoplanin (PDPN)) are assessed. CD4+ and CD8+ TILs are significantly associated with smoking and alcohol habits. CD4+ and CD8+ TILs show an inverse relationship with NANOG and SOX2 expression, and FOXP3+ TILs is significantly correlated with Nestin and PDPN expression. High infiltration of CD4+ and CD8+ TILs and a high tumoral CD8+/FOXP3+ ratio are significantly associated with tumors harboring positive PD-L1 expression. Infiltration of stromal/tumoral FOXP3+ TILs and a low stromal CD8+/FOXP3+ ratio are significantly associated with better disease-specific survival. Multivariate analysis reveals that the stromal CD8+/FOXP3+ TILs ratio is a significant independent prognostic factor. Regarding OSCC patient survival, the CD8+/FOXP3+ TILs ratio is an independent prognostic factor. TILs may act as biomarkers and potential therapeutic targets for OSCC.

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