scholarly journals Intrinsic functional connectivity in late-life depression: trajectories over the course of pharmacotherapy in remitters and non-remitters

2016 ◽  
Vol 22 (3) ◽  
pp. 450-457 ◽  
Author(s):  
H T Karim ◽  
C Andreescu ◽  
D Tudorascu ◽  
S F Smagula ◽  
M A Butters ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Late Life ◽  
Late Life Depression ◽  
Intrinsic Functional Connectivity

scholarly journals Corticostriatothalamic reward prediction error signals and executive control in late-life depression

2014 ◽  
Vol 45 (7) ◽  
pp. 1413-1424 ◽  
Author(s):  
A. Y. Dombrovski ◽  
K. Szanto ◽  
L. Clark ◽  
H. J. Aizenstein ◽  
H. W. Chase ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Executive Control ◽  
Late Life ◽  
Vascular Lesions ◽  
Contingency Learning ◽  
Late Life Depression ◽  
Vascular Depression ◽  
Fmri Study ◽  
Core Feature ◽  
Control Functional

BackgroundAltered corticostriatothalamic encoding of reinforcement is a core feature of depression. Here we examine reinforcement learning in late-life depression in the theoretical framework of the vascular depression hypothesis. This hypothesis attributes the co-occurrence of late-life depression and poor executive control to prefrontal/cingulate disconnection by vascular lesions.MethodOur fMRI study compared 31 patients aged ⩾60 years with major depression to 16 controls. Using a computational model, we estimated neural and behavioral responses to reinforcement in an uncertain, changing environment (probabilistic reversal learning).ResultsPoor executive control and depression each explained distinct variance in corticostriatothalamic response to unexpected rewards. Depression, but not poor executive control, predicted disrupted functional connectivity between the striatum and prefrontal cortex. White-matter hyperintensities predicted diminished corticostriatothalamic responses to reinforcement, but did not mediate effects of depression or executive control. In two independent samples, poor executive control predicted a failure to persist with rewarded actions, an effect distinct from depressive oversensitivity to punishment. The findings were unchanged in a subsample of participants with vascular disease. Results were robust to effects of confounders including psychiatric comorbidities, physical illness, depressive severity, and psychotropic exposure.ConclusionsContrary to the predictions of the vascular depression hypothesis, altered encoding of rewards in late-life depression is dissociable from impaired contingency learning associated with poor executive control. Functional connectivity and behavioral analyses point to a disruption of ascending mesostriatocortical reward signals in late-life depression and a failure of cortical contingency encoding in elderly with poor executive control.

scholarly journals Resting state functional connectivity and treatment response in late-life depression

2013 ◽  
Vol 214 (3) ◽  
pp. 313-321 ◽  
Author(s):  
Carmen Andreescu ◽  
Dana L. Tudorascu ◽  
Meryl A. Butters ◽  
Erica Tamburo ◽  
Meenal Patel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Treatment Response ◽  
Resting State ◽  
Late Life ◽  
Late Life Depression ◽  
Resting State Functional Connectivity

scholarly journals Functional connectivity predictors of acute depression treatment outcome

2019 ◽  
Vol 31 (12) ◽  
pp. 1831-1835 ◽  
Author(s):  
David C. Steffens ◽  
Lihong Wang ◽  
Godfrey D. Pearlson
Keyword(s):  
Functional Connectivity ◽  
Rating Scale ◽  
Inferior Frontal Gyrus ◽  
Late Life ◽  
Multivariate Regression Analysis ◽  
Brain Regions ◽  
Frontal Eye Field ◽  
Late Life Depression ◽  
Madrs Score ◽  
Sensorimotor Network

ABSTRACTFew studies have examined functional connectivity (FC) patterns using functional magnetic resonance imaging (fMRI) to predict outcomes in late-life depression. We hypothesized that FC within and between frontal and limbic regions would be associated with 12-week depression outcome in older depressed adults. Seventy-one subjects with major depression were enrolled in the study. A study geriatric psychiatrist performed a clinical interview and completed a Montgomery-Åsberg Depression Rating Scale (MADRS). All study participants were free of medication at baseline and had a brain fMRI scan. Using a regions of interest (ROI) atlas (including 164 ROIs), we conducted ROI-to-ROI resting-state FC analyses for each participant. In terms of treatment participants were offered sertraline initially, although in this naturalistic study, other medications were also prescribed. Subjects were evaluated every 2 weeks up to 12 weeks by the study psychiatrist, who followed a flexible, clinically based medication dosing schedule. Multivariate regression analysis was used to examine correlation between change of MADRS score over 12 weeks and baseline FC between brain regions, controlling for age, gender, mean head motion, and baseline MADRS. We found greater FC between the left inferior frontal gyrus pars triangularis and the left frontal eye field and FC of these two regions with a number of brain regions related to reward, salience, and sensorimortor function were correlated with change in MADRS score over 12 weeks. Our results highlight the important role of between inner speech-reward, attention-salience, and attention-sensorimotor network synchronization in predicting acute treatment response in late-life depression.

scholarly journals Functional connectivity in apathy of late-life depression: A preliminary study

2013 ◽  
Vol 149 (1-3) ◽  
pp. 398-405 ◽  
Author(s):  
George S. Alexopoulos ◽  
Matthew J. Hoptman ◽  
Genevieve Yuen ◽  
Dora Kanellopoulos ◽  
Joanna K. Seirup ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Late Life ◽  
Late Life Depression ◽  
Preliminary Study

Decreased Functional Connectivity in Salience Network is Correlated with Dysfunctional Attitude in Late Life Depression

2015 ◽  
Vol 23 (3) ◽  
pp. S161-S163
Author(s):  
Chemin Lin ◽  
Chih-Mao Huang ◽  
Yau-Yau Wai ◽  
Ho-Ling Liu ◽  
Tatia Mei-Chun Lee ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Late Life ◽  
Salience Network ◽  
Late Life Depression ◽  
Dysfunctional Attitude

Loneliness in late-life depression: structural and functional connectivity during affective processing

2016 ◽  
Vol 46 (12) ◽  
pp. 2485-2499 ◽  
Author(s):  
N. M. L. Wong ◽  
H.-L. Liu ◽  
C. Lin ◽  
C.-M. Huang ◽  
Y.-Y. Wai ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Emotion Dysregulation ◽  
Diffusion Tensor ◽  
Structural Connectivity ◽  
Late Life ◽  
The Elderly ◽  
Affective Processing ◽  
Late Life Depression ◽  
Processing Task ◽  
Affective Stimuli

BackgroundLate-life depression (LLD) in the elderly was reported to present with emotion dysregulation accompanied by high perceived loneliness. Previous research has suggested that LLD is a disorder of connectivity and is associated with aberrant network properties. On the other hand, perceived loneliness is found to adversely affect the brain, but little is known about its neurobiological basis in LLD. The current study investigated the relationships between the structural connectivity, functional connectivity during affective processing, and perceived loneliness in LLD.MethodThe current study included 54 participants aged >60 years of whom 31 were diagnosed with LLD. Diffusion tensor imaging (DTI) data and task-based functional magnetic resonance imaging (fMRI) data of an affective processing task were collected. Network-based statistics and graph theory techniques were applied, and the participants’ perceived loneliness and depression level were measured. The affective processing task included viewing affective stimuli.ResultsStructurally, a loneliness-related sub-network was identified across all subjects. Functionally, perceived loneliness was related to connectivity differently in LLD than that in controls when they were processing negative stimuli, with aberrant networking in subcortical area.ConclusionsPerceived loneliness was identified to have a unique role in relation to the negative affective processing in LLD at the functional brain connectional and network levels. The findings increas our understanding of LLD and provide initial evidence of the neurobiological mechanisms of loneliness in LLD. Loneliness might be a potential intervention target in depressive patients.

Sign in / Sign up

Export Citation Format

Share Document