Fast Performance Modeling across Different Database Versions Using Partitioned Co-Kriging

Database systems have a large number of configuration parameters that control functional and non-functional properties (e.g., performance and cost). Different configurations may lead to different performance values. To understand and predict the effect of configuration parameters on system performance, several learning-based strategies have been recently proposed. However, existing approaches usually assume a fixed database version such that learning has to be repeated once the database version changes. Repeating measurement and learning for each version is expensive and often practically infeasible. Instead, we propose the Partitioned Co-Kriging (PCK) approach that transfers knowledge from an older database version (source domain) to learn a reliable performance prediction model fast for a newer database version (target domain). Our method is based on the key observations that performance responses typically exhibit similarities across different database versions. We conducted extensive experiments under 5 different database systems with different versions to demonstrate the superiority of PCK. Experimental results show that PCK outperforms six state-of-the-art baseline algorithms in terms of prediction accuracy and measurement effort.

Heart rate variability and emotional state dynamics in zumba class

The relevance of the research question arises from the need to assess the safety and benefits of Zumba®Fitness classes as well as from the lack of diagnostic and methodological tools to plan the training and predict fitness outcomes. The aim of this article was to examine heart rate variability (HRV) and emotional disadaptation (ED) during Zumba®Fitness classes. Wireless cardiointervalography as well as the LED (level of emotional disadaptation) test were used as empirical research methods. The paper showed the effect of Zumba®Fitness on HRV, as well as on LED. Practical significance: The current study proves the necessity to control functional stateduring fitness training, which is an important factor in planning the training process and predicting its results. At the same time, good results of fitness training require the use of modern diagnostic technologies based on objective research methods.

A novel post-developmental role of the Hox genes underlies normal adult behaviour

The molecular mechanisms underlying the stability of mature neurons and neural circuits are poorly understood. Here we explore this problem and discover that the Hox genes are a component of the genetic programme that maintains normal neural function in adult Drosophila. We show that post-developmental downregulation of the Hox gene Ultrabithorax (Ubx) in adult neurons leads to substantial anomalies in flight. Mapping the cellular basis of these effects reveals that Ubx is required within a subset of dopaminergic neurons, and cell circuitry analyses and optogenetics allow us to link these dopaminergic neurons to flight control. Functional imaging experiments show that Ubx is necessary for normal dopaminergic activity, and neuron-specific RNA-sequencing defines two previously uncharacterised ion channel-encoding genes as potential mediators of Ubx behavioural roles. Our study thus reveals a novel role of the Hox system in controlling adult behaviour and neural function.

Review of Coveralls, Gowns, and their Use as Part of Personal Protective Equipment (PPE KIT) for Effective Protection of Healthcare Workers in India in COVID-19

Healthcare Workers (HCWs) and public health professionals are playing a pivotal role in containing COVID-19. Personal Protective Equipment (PPEs) are a critical component in the hierarchy of primary infection controls to ‘break the chain of infection’ to protect patients, HCW’s, and public. As SARS-CoV-2 is highly contagious, and vaccine and prophylactics not yet available, understanding correct PPE usage is imperative. This study aims to: understand purpose, use, and quality standards of body-coveralls and gowns and how to use PPE’s for effective protection in COVID 19 in India. Types of PPE’s in healthcare, their purposes, materials used, and properties were reviewed. Gowns and Body-coveralls classification and standards in Europe, USA and India were studied. While current stipulated test standards for coveralls in India are lower, as routine use of reusable gowns made of woven fabrics is more common in India, one could hypothesize that these coveralls provide a higher level of protection. As per current understanding of mode(s) of transmission of SARS-CoV-2 a properly fitted N95 respirator; goggles and splash resistant face shield; gloves; and single-use full body-coverall/gown preferably resistant to Synthetic Blood Penetration under pressure and made of non-woven Laminated SMS (Spunbond-Meltblown-Spunbond)_or Non Laminated SSMMS fabrics are advisable depending upon anticipated level of exposure. HCW’s should educated about transmission risks, correct principles of infection control, functional purpose of PPE’s and must be conscious that PPE’s alone will not protect them. They must follow good practices of how to wear (don) and how to remove (doff) and ensure that they do not inadvertently contaminate their clothing/skin and self-inoculate.

Automated Ontology-Based Security Requirements Identification for the Vehicular Domain

Many electronic and electrical systems are now incorporated with modern vehicles to control functional safety. Lack of security protection mechanisms in vehicular design may lead to different ways of executing malicious attacks against the vehicular network. These attacks may have various types of negative consequences, such as safe vehicle operation. This work presents an ontology-based framework as a new automated approach to verify and validate security requirements against security issues in the vehicular domain. The system also applies a set of logical rules to identify a set of security requirements as a category of necessary security requirements that could be proposed to be integrated within the vehicle design to address a specific security issue.

A steric gate controls P/E hybrid-state formation of tRNA on the ribosome

The ribosome is a biomolecular machine that undergoes multiple large-scale structural rearrangements during protein elongation. Here, we focus on a conformational rearrangement during translocation, known as P/E hybrid-state formation. Using a model that explicitly represents all non-hydrogen atoms, we simulated more than 120 spontaneous transitions, where the tRNA molecule is displaced between the P and E sites of the large subunit. In addition to predicting a free-energy landscape that is consistent with previous experimental observations, the simulations reveal how a six-residue gate-like region can limit P/E formation, where sub-angstrom structural perturbations lead to an order-of-magnitude change in kinetics. Thus, this precisely defined set of residues represents a novel target that may be used to control functional dynamics in bacterial ribosomes. This theoretical analysis establishes a direct relationship between ribosome structure and large-scale dynamics, and it suggests how next-generation experiments may precisely dissect the energetics of hybrid formation on the ribosome.

Pharmacological and non-pharmacological interventions to improve symptom control, functional exercise capacity and quality of life in interstitial lung disease: an evidence synthesis

We assessed efficacy and effectiveness of pharmacological and non-pharmacological interventions in improving symptom control, functional exercise capacity and quality of life (Qol) in people living with fibrotic interstitial lung disease (ILD).We summarised evidence from three previous reviews (to June 2014) and conducted an updated search of nine databases and grey literature (2011–19) (registration: CRD42017065933) for prospective studies of interventions aimed to alleviate symptoms, improve Qol or functional exercise capacity in fibrotic ILD. Data were synthesised through narrative synthesis or meta-analysed as appropriate.Forty-seven studies with 2527 participants were included. From 22 pharmacological studies of eleven different interventions (n=1683) the most tested interventions were bosentan and sildenafil. From 25 non-pharmacological studies, the most tested intervention was for pulmonary rehabilitation / exercise training (PR) (22 studies, n=748). An improvement in 6-min walk distance (6MWD) immediately following PR (6 studies; n=200, MD [95%CI] 39.9 m [18.2 to 61.5]) but not longer-term (3 or 6 months, 4 studies; n=147, MD 5.3 m [−12.9 to 23.4]. Multiple, varied outcome measures were used, e.g. 37 studies assessing dyspnoea used 10 different scales with lack of reporting of rate of deterioration in outcomes. Evidence gap mapping highlighted the most and least researched symptoms were dyspnoea and cough respectively.This evidence synthesis highlights overwhelmingly that the most researched symptom is dyspnoea and the strongest evidence base is for short-term PR. The least researched symptom was cough. Research going forward must focus on prioritising and standardising meaningful outcomes and focusing interventions on neglected symptoms.