scholarly journals Erratum: mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors

2017 ◽  
Vol 23 (1) ◽  
pp. 164-164 ◽  
Author(s):  
F Liu ◽  
S Laguesse ◽  
R Legastelois ◽  
N Morisot ◽  
S Ben Hamida ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Collapsin Response Mediator Protein ◽  
Mediator Protein ◽  
Excessive Alcohol ◽  
Drinking Behaviors

scholarly journals mTORC1-dependent translation of collapsin response mediator protein-2 drives neuroadaptations underlying excessive alcohol-drinking behaviors

2016 ◽  
Vol 22 (1) ◽  
pp. 89-101 ◽  
Author(s):  
F Liu ◽  
S Laguesse ◽  
R Legastelois ◽  
N Morisot ◽  
S Ben Hamida ◽  
...  
Keyword(s):  
Alcohol Drinking ◽  
Collapsin Response Mediator Protein ◽  
Mediator Protein ◽  
Excessive Alcohol ◽  
Drinking Behaviors

scholarly journals AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors

2011 ◽  
Vol 70 (6) ◽  
pp. 575-582 ◽  
Author(s):  
Jérémie Neasta ◽  
Sami Ben Hamida ◽  
Quinn V. Yowell ◽  
Sebastien Carnicella ◽  
Dorit Ron
Keyword(s):  
Nucleus Accumbens ◽  
Signaling Pathway ◽  
Alcohol Drinking ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Excessive Alcohol ◽  
Drinking Behaviors

scholarly journals Spastin interacts with CRMP5 to promote spindle organization in mouse oocytes by severing microtubules

Zygote ◽  
2021 ◽  
pp. 1-12
Author(s):  
Zhen Jin ◽  
Hua-Feng Shou ◽  
Jin-Wei Liu ◽  
Shan-Shan Jiang ◽  
Yan Shen ◽  
...  
Keyword(s):  
Developmental Disorders ◽  
Spindle Microtubule ◽  
Collapsin Response Mediator Protein ◽  
Microtubule Severing ◽  
Structural Support ◽  
Mediator Protein ◽  
Spindle Microtubules ◽  
Transportation Routes ◽  
Normal Meiosis

Abstract Microtubule-severing protein (MTSP) is critical for the survival of both mitotic and postmitotic cells. However, the study of MTSP during meiosis of mammalian oocytes has not been reported. We found that spastin, a member of the MTSP family, was highly expressed in oocytes and aggregated in spindle microtubules. After knocking down spastin by specific siRNA, the spindle microtubule density of meiotic oocytes decreased significantly. When the oocytes were cultured in vitro, the oocytes lacking spastin showed an obvious maturation disorder. Considering the microtubule-severing activity of spastin, we speculate that spastin on spindles may increase the number of microtubule broken ends by severing the microtubules, therefore playing a nucleating role, promoting spindle assembly and ensuring normal meiosis. In addition, we found the colocalization and interaction of collapsin response mediator protein 5 (CRMP5) and spastin in oocytes. CRMP5 can provide structural support and promote microtubule aggregation, creating transportation routes, and can interact with spastin in the microtubule activity of nerve cells (30). Knocking down CRMP5 may lead to spindle abnormalities and developmental disorders in oocytes. Overexpression of spastin may reverse the abnormal phenotype caused by the deletion of CRMP5. In summary, our data support a model in which the interaction between spastin and CRMP5 promotes the assembly of spindle microtubules in oocytes by controlling microtubule dynamics, therefore ensuring normal meiosis.

scholarly journals Collapsin response mediator protein 3 deacetylates histone H4 to mediate nuclear condensation and neuronal death

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Sheng T. Hou ◽  
Susan X. Jiang ◽  
Amy Aylsworth ◽  
Matthew Cooke ◽  
Lei Zhou
Keyword(s):  
Neuronal Death ◽  
Histone H4 ◽  
Nuclear Condensation ◽  
Collapsin Response Mediator Protein ◽  
Mediator Protein

The protein interactome of collapsin response mediator protein-2 (CRMP2/DPYSL2) reveals novel partner proteins in brain tissue

2015 ◽  
Vol 9 (9-10) ◽  
pp. 817-831 ◽  
Author(s):  
Daniel Martins-de-Souza ◽  
Juliana S. Cassoli ◽  
Juliana M. Nascimento ◽  
Kenneth Hensley ◽  
Paul C. Guest ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Collapsin Response Mediator Protein ◽  
Protein Interactome ◽  
Mediator Protein ◽  
Partner Proteins

scholarly journals Genetic suppression of collapsin response mediator protein 2 phosphorylation improves outcome in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s model mice

2018 ◽  
Vol 24 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Kentaro Togashi ◽  
Masaya Hasegawa ◽  
Jun Nagai ◽  
Aine Tonouchi ◽  
Daiki Masukawa ◽  
...  
Keyword(s):  
Collapsin Response Mediator Protein ◽  
Mediator Protein ◽  
Genetic Suppression
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