Erratum: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.

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Calcineurin Localizes to the Hyphal Septum in Aspergillus fumigatus: Implications for Septum Formation and Conidiophore Development

Eukaryotic Cell ◽

10.1128/ec.00200-08 ◽

2008 ◽

Vol 7 (9) ◽

pp. 1606-1610 ◽

Cited By ~ 31

Author(s):

Praveen Rao Juvvadi ◽

Jarrod R. Fortwendel ◽

Nadthanan Pinchai ◽

B. Zachary Perfect ◽

Joseph Heitman ◽

...

Keyword(s):

Green Fluorescent Protein ◽

Aspergillus Fumigatus ◽

Filamentous Fungus ◽

Enhanced Green Fluorescent Protein ◽

Fluorescent Protein ◽

Dependent Manner ◽

Septum Formation ◽

Calcineurin A ◽

Green Fluorescent

ABSTRACT A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus ΔcnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.

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Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

mBio ◽

10.1128/mbio.01458-21 ◽

2021 ◽

Author(s):

Thaila Fernanda dos Reis ◽

Maria Augusta Crivelente Horta ◽

Ana Cristina Colabardini ◽

Caroline Mota Fernandes ◽

Lilian Pereira Silva ◽

...

Keyword(s):

Aspergillus Fumigatus ◽

Mechanism Of Action ◽

Filamentous Fungus ◽

Antifungal Drugs ◽

Clinical Isolates ◽

Content Type ◽

Chemical Libraries

The filamentous fungus Aspergillus fumigatus causes a group of diseases named aspergillosis, and their development occurs after the inhalation of conidia dispersed in the environment. Very few classes of antifungal drugs are available for aspergillosis treatment, e.g., azoles, but the emergence of global resistance to azoles in A. fumigatus clinical isolates has increased over recent decades.

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Draft Genome Sequence of the Pathogenic Filamentous Fungus Aspergillus lentulus IFM 54703 T

Genome Announcements ◽

10.1128/genomea.01568-15 ◽

2016 ◽

Vol 4 (1) ◽

Cited By ~ 6

Author(s):

Yoko Kusuya ◽

Kanae Sakai ◽

Katsuhiko Kamei ◽

Hiroki Takahashi ◽

Takashi Yaguchi

Keyword(s):

Aspergillus Fumigatus ◽

Genome Sequence ◽

Causative Agent ◽

Sibling Species ◽

Filamentous Fungus ◽

Draft Genome ◽

Draft Genome Sequence ◽

Aspergillus Lentulus ◽

First Time

Aspergillus lentulus , a sibling species of Aspergillus fumigatus , has been reported as a causative agent of aspergillosis, and exhibited low susceptibility to azole. Here, we present the draft genome sequence of A. lentulus strain IFM 54703 T for the first time.

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