scholarly journals Aspergillus fumigatus, One Uninucleate Species with Disparate Offspring

2021 ◽  
Vol 7 (1) ◽  
pp. 30
Author(s):  
François Danion ◽  
Norman van Rhijn ◽  
Alexandre C. Dufour ◽  
Rachel Legendre ◽  
Odile Sismeiro ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Aspergillus Fumigatus ◽  
Filamentous Fungus ◽  
Fungal Species ◽  
Conidial Germination ◽  
Biological Cycle ◽  
Gene Deletions ◽  
Airborne Conidia ◽  
Nutritional Environment ◽  
Germination Parameters

Establishment of a fungal infection due to Aspergillus fumigatus relies on the efficient germination of the airborne conidia once they penetrate the respiratory tract. However, the features of conidial germination have been poorly explored and understood in this fungal species as well as in other species of filamentous fungi. We show here that the germination of A. fumigatus is asynchronous. If the nutritional environment and extensive gene deletions can modify the germination parameters for A. fumigatus, the asynchrony is maintained in all germinative conditions tested. Even though the causes for this asynchrony of conidial germination remain unknown, asynchrony is essential for the completion of the biological cycle of this filamentous fungus.

Prevalence of Aspergillus fumigatus and other fungal species in the sputum of adult patients with cystic fibrosis

Mycoses ◽  
2003 ◽  
Vol 46 (1-2) ◽  
pp. 19-23 ◽  
Author(s):  
N. Bakare ◽  
V. Rickerts ◽  
J. Bargon ◽  
G. Just-Nübling
Keyword(s):  
Cystic Fibrosis ◽  
Aspergillus Fumigatus ◽  
Fungal Species ◽  
Adult Patients

scholarly journals Erratum: Corrigendum: Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

Nature ◽  
2006 ◽  
Vol 439 (7075) ◽  
pp. 502-502 ◽  
Author(s):  
William C. Nierman ◽  
Arnab Pain ◽  
Michael J. Anderson ◽  
Jennifer R. Wortman ◽  
H. Stanley Kim ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Filamentous Fungus ◽  
Genomic Sequence

scholarly journals PRESENTATION PATTERN AND FUNGAL AGENTS SPECTRUM CAUSING OTOMMYCOSIS

2018 ◽  
Vol 11 (1) ◽  
pp. 408
Author(s):  
Kassim Dekhil
Keyword(s):  
Candida Albicans ◽  
Aspergillus Niger ◽  
Aspergillus Fumigatus ◽  
Influencing Factors ◽  
Aspergillus Flavus ◽  
Species Distribution ◽  
Alternaria Alternata ◽  
Otitis Externa ◽  
Fungal Species ◽  
The Public

 Objective: This study was aimed to identify the public pattern of presentation, influencing factors, and sort the fungal species, distribution of sex of patients with otomycosis.Results: The predominant complaints were pruritus and found in 76 patients (88.73%), discomfort and pain found in 62 patients (72.09%), aural fullness in 48 patients (55.81%), tinnitus in 34 patients (39.53%), hearing impairment in 50 cases (58.31%), ear discharge in 22 patients (25.58%), and most of the symptoms seen in 36 patients (68.14%). The results showed a total of eight fungal species belong to six different genera, namely, Aspergillus, Candida, Penicillium, Rhizopus, Alternaria, and Cephalosporium were isolated during this study. Among identified fungi, Aspergillus niger was found to be the most prevalent fungal species with 35.71% followed by Candida albicans (27.55%), Aspergillus flavus (10.20%), Aspergillus fumigatus (8.16), Penicillium digitatum (6.12%) and Cephalosporium species (4.08%), and Rhizopus species (5.1%), while Alternaria alternata had the lowest percentage (6.54%).Conclusion: Otomycosis/mycotic otitis externa is still a common problem and there is a rise in the occurrence of otomycosis in latest years, especially in tropical and subtropical humid climates.

Thermophilous fungi of decomposing sugarcane bagasse

1980 ◽  
Vol 58 (18) ◽  
pp. 2015-2016 ◽  
Author(s):  
D. K. Sandhu ◽  
Surinder Singh ◽  
M. K. Waraich
Keyword(s):  
Aspergillus Fumigatus ◽  
Sugarcane Bagasse ◽  
New Record ◽  
Fungal Species ◽  
Northern India ◽  
First Time ◽  
Temperature Responses

Twenty species of thermophilous fungi were identified from sugarcane bagasse at Batala in Northern India. Seven fungal species are reported from bagasse for the first time and Aspergillus caespitosns is a new record for India. Aspergillus fumigatus was the most common fungus followed by Mncor pusillus. The temperature responses of the fungi revealed 5 microthermophiles, 11 thermotolerant, and 4 true thermophiles. Three species of thermophilous fungi are reported in addition to those already recorded in the literature.

scholarly journals The Volatome of Aspergillus fumigatus

2014 ◽  
Vol 13 (8) ◽  
pp. 1014-1025 ◽  
Author(s):  
C. Heddergott ◽  
A. M. Calvo ◽  
J. P. Latgé
Keyword(s):  
Aspergillus Fumigatus ◽  
Growth Conditions ◽  
Terpene Biosynthesis ◽  
Content Type ◽  
Volatile Organic ◽  
Volatile Terpenes ◽  
Nutritional Environment ◽  
Volatile Production ◽  
Related Compounds

ABSTRACT Early detection of invasive aspergillosis is absolutely required for efficient therapy of this fungal infection. The identification of fungal volatiles in patient breath can be an alternative for the detection of Aspergillus fumigatus that still remains problematic. In this work, we investigated the production of volatile organic compounds (VOCs) by A. fumigatus in vitro , and we show that volatile production depends on the nutritional environment. A. fumigatus produces a multiplicity of VOCs, predominantly terpenes and related compounds. The production of sesquiterpenoid compounds was found to be strongly induced by increased iron concentrations and certain drugs, i.e., pravastatin. Terpenes that were always detectable in large amounts were α-pinene, camphene, and limonene, as well as sesquiterpenes, identified as α-bergamotene and β- trans -bergamotene. Other substance classes that were found to be present in the volatome, such as 1-octen-3-ol, 3-octanone, and pyrazines, were found only under specific growth conditions. Drugs that interfere with the terpene biosynthesis pathway influenced the composition of the fungal volatome, and most notably, a block of sesquiterpene biosynthesis by the bisphosphonate alendronate fundamentally changed the VOC composition. Using deletion mutants, we also show that a terpene cyclase and a putative kaurene synthase are essential for the synthesis of volatile terpenes by A. fumigatus . The present analysis of in vitro volatile production by A. fumigatus suggests that VOCs may be used in the diagnosis of infections caused by this fungus.

scholarly journals Calcineurin Localizes to the Hyphal Septum in Aspergillus fumigatus: Implications for Septum Formation and Conidiophore Development

2008 ◽  
Vol 7 (9) ◽  
pp. 1606-1610 ◽  
Author(s):  
Praveen Rao Juvvadi ◽  
Jarrod R. Fortwendel ◽  
Nadthanan Pinchai ◽  
B. Zachary Perfect ◽  
Joseph Heitman ◽  
...  
Keyword(s):  
Green Fluorescent Protein ◽  
Aspergillus Fumigatus ◽  
Filamentous Fungus ◽  
Enhanced Green Fluorescent Protein ◽  
Fluorescent Protein ◽  
Dependent Manner ◽  
Septum Formation ◽  
Calcineurin A ◽  
Green Fluorescent

ABSTRACT A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus ΔcnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.

scholarly journals Fungal Diversity in Droppings of Spot- Billed Pelican, Pelecanus philippensis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kavitha N ◽  
Zehra Amtuz
Keyword(s):  
Public Health ◽  
Aspergillus Niger ◽  
Health Risk ◽  
Aspergillus Fumigatus ◽  
Aspergillus Flavus ◽  
Fungal Diversity ◽  
Fungal Species ◽  
Public Health Risk

Birds are potential vectors of some diseases as their droppings pose public health risk and cause illness. Dust containing dry faeces after inhaling can infects humans. The prevalence of fungi from the faeces of birds in wetlands has not been previously determined. Hence, the present study was carried out to isolate and identify different fungal species present in the droppings of spot-billed pelican, Pelecanus philippensis. Among the fungal species identified Aspergillus flavus, Aspergillus niger and Aspergillus fumigatus were found to be dominating.

scholarly journals Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

mBio ◽  
2021 ◽  
Author(s):  
Thaila Fernanda dos Reis ◽  
Maria Augusta Crivelente Horta ◽  
Ana Cristina Colabardini ◽  
Caroline Mota Fernandes ◽  
Lilian Pereira Silva ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Mechanism Of Action ◽  
Filamentous Fungus ◽  
Antifungal Drugs ◽  
Clinical Isolates ◽  
Content Type ◽  
Chemical Libraries

The filamentous fungus Aspergillus fumigatus causes a group of diseases named aspergillosis, and their development occurs after the inhalation of conidia dispersed in the environment. Very few classes of antifungal drugs are available for aspergillosis treatment, e.g., azoles, but the emergence of global resistance to azoles in A. fumigatus clinical isolates has increased over recent decades.

scholarly journals OMPARATIVE ANTIFUNGAL ACTIVITY OF WILD AND CULTIVATED LEAVES OF FICUS CARICA LINN

2021 ◽  
Vol 29 (03) ◽  
Author(s):  
Nangial Bashir Ullah
Keyword(s):  
Antifungal Activity ◽  
Aspergillus Niger ◽  
Aspergillus Fumigatus ◽  
Fungal Species ◽  
Ficus Carica ◽  
Zone Of Inhibition ◽  
Polar Solvents ◽  
Common Fig ◽  
Cultivated Species ◽  
Tube Dilution

Objective: To compare the antifungal activity of wild and cultivated Ficus carica Linn (common fig) leaves extract Materials and Methods: An experimental study was conducted in the department of Botany Islamia College Peshawar from June 2016 to December 2016 which was shaped in 2021 into a research study in the Department of Community Medicine, Khyber Medical College Peshawar. The agar tube dilution method was used for antifungal activity of the extracts. Results: Comparison of Zone of Inhibition (%) in both Aspergillus niger and Aspergillus fumigatus colonies revealed that cultivated species of Ficus carica Linn (common fig locally known as Anjeer ) had more antifungal property against both the fungal species (63% and higher compared that to wild species having maximum zone of inhibition of 54.54%) with the exception of wild plant extract in polar solvent such as chloroform which had high level of antifungal activity (61.53%) only against Aspegillus fumigatus. The experiment also revealed that extracts from both wild and cultivated Ficus carica Linn leaves in polar solvents such as methanol( also written and referred to methanolic in the article) and chloroform showed higher level of antifungal activity against both the fungal species compared to extract taken in non-polar solvents.   Conclusion: Extract from cultivated species of Ficus carica Linn had higher level of activity against both the fungal species i.e. Aspergillus niger and Aspergillus fumigatus, especially extract taken in polar solvents. Key words: Ficus carica Linn, antifungal, tube dilution, zone of inhibition   

scholarly journals Coinfection with Pseudomonas aeruginosa and Aspergillus fumigatus in cystic fibrosis

2020 ◽  
Vol 29 (158) ◽  
pp. 200011
Author(s):  
Karen Keown ◽  
Alastair Reid ◽  
John E. Moore ◽  
Clifford C. Taggart ◽  
Damian G. Downey
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Aspergillus Fumigatus ◽  
Lung Disease ◽  
Disease Progression ◽  
Expert Knowledge ◽  
Fungal Species ◽  
Interspecies Interactions ◽  
Cross Sectional ◽  
Infection And Inflammation

ObjectivesCystic fibrosis (CF) lung disease is characterised by mucus stasis, chronic infection and inflammation, causing progressive structural lung disease and eventual respiratory failure. CF airways are inhabited by an ecologically diverse polymicrobial environment with vast potential for interspecies interactions, which may be a contributing factor to disease progression. Pseudomonas aeruginosa and Aspergillus fumigatus are the most common bacterial and fungal species present in CF airways respectively and coinfection results in a worse disease phenotype.MethodsIn this review we examine existing expert knowledge of chronic co-infection with P. aeruginosa and A. fumigatus in CF patients. We summarise the mechanisms of interaction and evaluate the clinical and inflammatory impacts of this co-infection.ResultsP. aeruginosa inhibits A. fumigatus through multiple mechanisms: phenazine secretion, iron competition, quorum sensing and through diffusible small molecules. A. fumigatus reciprocates inhibition through gliotoxin release and phenotypic adaptations enabling evasion of P. aeruginosa inhibition. Volatile organic compounds secreted by P. aeruginosa stimulate A. fumigatus growth, while A. fumigatus stimulates P. aeruginosa production of cytotoxic elastase.ConclusionA complex bi-directional relationship exists between P. aeruginosa and A. fumigatus, exhibiting both mutually antagonistic and cooperative facets. Cross-sectional data indicate a worsened disease state in coinfected patients; however, robust longitudinal studies are required to derive causality and to determine whether interspecies interaction contributes to disease progression.

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