Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia

A 46-year-old woman with a known history of acute myeloid leukaemia presented with bilateral breast masses with pain and itchiness. The breast masses were hard on palpation. Mammogram was unremarkable. Ultrasound showed multiple conglomerated masses of heterogeneous hyperechogenicity and hypoechogenicity throughout all quadrants of bilateral breasts. Pathology showed mononuclear cells, suggestive of breast leukaemic infiltration. She was treated with decitabine and platelet transfusion.

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PO030 A rare history of a patient with acute myeloid leukaemia transformed in myelodysplastic syndrome

Leukemia Research ◽

10.1016/s0145-2126(07)70260-6 ◽

2007 ◽

Vol 31 ◽

pp. S143-S144

Author(s):

L. Mehes

Keyword(s):

Acute Myeloid Leukaemia ◽

Myelodysplastic Syndrome ◽

Myeloid Leukaemia ◽

History Of ◽

Acute Myeloid

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Teenager with a history of acute myeloid leukaemia with an isolated brain lesion

BMJ Case Reports ◽

10.1136/bcr-2020-234857 ◽

2020 ◽

Vol 13 (5) ◽

pp. e234857

Author(s):

Donna Johnston ◽

Joerg Krueger ◽

Lesleigh Abbott

Keyword(s):

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Brain Lesion ◽

History Of ◽

Acute Myeloid

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Male with myelofibrosis and ulceronecrotic lesions

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.64.12.1073 ◽

2018 ◽

Vol 64 (12) ◽

pp. 1073-1074

Author(s):

Flávia da Silva Domingos Santos ◽

Priscila Vinhal Grupioni ◽

Loan Towersey ◽

Fred Bernardes Filho

Keyword(s):

Chronic Myeloid Leukaemia ◽

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Myelodysplastic Syndromes ◽

Past History ◽

Granulocytic Sarcoma ◽

Myeloproliferative Disorders ◽

Rare Entity ◽

History Of ◽

Acute Myeloid

SUMMARY Granulocytic sarcoma also called myeloid sarcoma is an extramedullary tumour of immature granulocytic cells. It is a rare entity, and mostly accompanied by acute myeloid leukaemia. It is observed during the course of myeloproliferative disorders especially in chronic myeloid leukaemia and myelodysplastic syndromes. Here, we report a case of a 60-year-old male with past history of myelofibrosis admitted to the emergency room due ulceronecrotic lesions, fever and dysphagia. We emphasize the importance of recognizing this entity and its severity.

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Acute myeloid leukaemia relapse presenting as cardiac myeloid sarcoma

BMJ Case Reports ◽

10.1136/bcr-2018-224419 ◽

2018 ◽

pp. bcr-2018-224419

Author(s):

Alexander Waselewski ◽

Michael Joiner ◽

Steven Raymond Miller

Keyword(s):

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Right Atrium ◽

Residual Disease ◽

Vena Cava ◽

Myeloid Sarcoma ◽

Adjuvant Radiation ◽

History Of ◽

The Right ◽

Acute Myeloid

A 50-year-old woman previously diagnosed with acute myeloid leukaemia presented with a 3-month history of shortness of breath and a right-sided facial rash. A chest CT revealed an intracardiac mass in the right atrium extending into her superior and inferior vena cava. Surgery was performed to remove the mass and pathology was consistent with myeloid sarcoma. After surgery, adjuvant radiation therapy was directed to the residual disease. The patient eventually relapsed in other sites not including the right atrium and eventually succumbed to her disease.

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First-dose idarubicin cardiomyopathy: a case of new heart failure after induction chemotherapy for acute myeloid leukaemia

BMJ Case Reports ◽

10.1136/bcr-2018-228149 ◽

2019 ◽

Vol 12 (5) ◽

pp. e228149 ◽

Cited By ~ 2

Author(s):

Zarir Ahmed ◽

Elizabeth Davaro ◽

Jacqueline Batanian ◽

Nilesh Verma

Keyword(s):

Heart Failure ◽

Acute Myeloid Leukaemia ◽

Myelodysplastic Syndrome ◽

Myeloid Leukaemia ◽

Acute Heart Failure ◽

Induction Chemotherapy ◽

Chemotherapy Agent ◽

History Of ◽

Acute Myeloid

Anthracyclines are an effective chemotherapy agent. However, very few cases of idarubicin-induced cardiomyopathy exist. Herein, we describe a case of first-dose idarubicin-related acute heart failure in a woman with a history of myelodysplastic syndrome converted to acute myeloid leukaemia.

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