scholarly journals Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

2015 ◽  
Vol 47 (11) ◽  
pp. 1282-1293 ◽  
Author(s):  
Norihiro Kato ◽  
◽  
Marie Loh ◽  
Fumihiko Takeuchi ◽  
Niek Verweij ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Dna Methylation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Genome Wide

scholarly journals Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Daniel L. McCartney ◽  
Josine L. Min ◽  
Rebecca C. Richmond ◽  
Ake T. Lu ◽  
Maria K. Sobczyk ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Genome Wide Association Study ◽  
Association Studies ◽  
Genome Wide Association ◽  
Biological Aging ◽  
Genome Wide Association Studies ◽  
Genetic Loci ◽  
Biomarkers Of Aging ◽  
Genome Wide ◽  
Shared Genetic

Abstract Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field. Results Leveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs. A polygenic score for GrimAge acceleration showed strong associations with adiposity-related traits, educational attainment, parental longevity, and C-reactive protein levels. Conclusion This study illuminates the genetic architecture underlying epigenetic aging and its shared genetic contributions with lifestyle factors and longevity.

scholarly journals A Genome-Wide Association Study for Hypertensive Kidney Disease in Korean Men

Genes ◽  
2021 ◽  
Vol 12 (5) ◽  
pp. 751
Author(s):  
Hye-Rim Kim ◽  
Hyun-Seok Jin ◽  
Yong-Bin Eom
Keyword(s):  
Blood Pressure ◽  
Kidney Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Integrated Analysis ◽  
Eqtl Analysis ◽  
Strong Linkage Disequilibrium ◽  
Genome Wide ◽  
A Genome

Hypertension is one of the major risk factors for chronic kidney disease (CKD), and the coexistence of hypertension and CKD increases morbidity and mortality. Although many genetic factors have been identified separately for hypertension and kidney disease, studies specifically focused on hypertensive kidney disease (HKD) have been rare. Therefore, this study aimed to identify loci or genes associated with HKD. A genome-wide association study (GWAS) was conducted using two Korean cohorts, the Health Examinee (HEXA) and Korean Association REsource (KARE). Consequently, 19 single nucleotide polymorphisms (SNPs) were found to be significantly associated with HKD in the discovery and replication phases (p < 5 × 10−8, p < 0.05, respectively). We further analyzed HKD-related traits such as the estimated glomerular filtration rate (eGFR), creatinine, blood urea nitrogen (BUN), systolic blood pressure (SBP) and diastolic blood pressure (DBP) at the 14q21.2 locus, which showed a strong linkage disequilibrium (LD). Expression quantitative trait loci (eQTL) analysis was also performed to determine whether HKD-related SNPs affect gene expression changes in glomerular and arterial tissues. The results suggested that the FANCM gene may affect the development of HKD through an integrated analysis of eQTL and GWAS and was the most significantly associated candidate gene. Taken together, this study indicated that the FANCM gene is involved in the pathogenesis of HKD. Additionally, our results will be useful in prioritizing other genes for further experiments.

scholarly journals Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

The Lancet ◽  
2008 ◽  
Vol 372 (9654) ◽  
pp. 1953-1961 ◽  
Author(s):  
Abbas Dehghan ◽  
Anna Köttgen ◽  
Qiong Yang ◽  
Shih-Jen Hwang ◽  
WH Linda Kao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Acid Concentration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Uric Acid Concentration ◽  
Genetic Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study identifies eight loci associated with blood pressure

2009 ◽  
Vol 41 (6) ◽  
pp. 666-676 ◽  
Author(s):  
Christopher Newton-Cheh ◽  
◽  
Toby Johnson ◽  
Vesela Gateva ◽  
Martin D Tobin ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Genome-wide association study identifies genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Hassan S. Dashti ◽  
Samuel E. Jones ◽  
Andrew R. Wood ◽  
Jacqueline M. Lane ◽  
Vincent T. van Hees ◽  
...  
Keyword(s):  
Association Study ◽  
Sleep Duration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Genome Wide

scholarly journals Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

PLoS Genetics ◽  
2010 ◽  
Vol 6 (10) ◽  
pp. e1001177 ◽  
Author(s):  
Sandosh Padmanabhan ◽  
Olle Melander ◽  
Toby Johnson ◽  
Anna Maria Di Blasio ◽  
Wai K. Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide
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