Faculty Opinions recommendation of Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study.

2011 ◽  
Author(s):  
Susan Bates
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Acid Concentration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Uric Acid Concentration ◽  
Genetic Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study

The Lancet ◽  
2008 ◽  
Vol 372 (9654) ◽  
pp. 1953-1961 ◽  
Author(s):  
Abbas Dehghan ◽  
Anna Köttgen ◽  
Qiong Yang ◽  
Shih-Jen Hwang ◽  
WH Linda Kao ◽  
...  
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Acid Concentration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Uric Acid Concentration ◽  
Genetic Loci ◽  
Genome Wide ◽  
A Genome

scholarly journals Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study

2018 ◽  
Vol 19 (6) ◽  
pp. 517-527
Author(s):  
Eero M Ala-Mutka ◽  
Jenni M Rimpelä ◽  
Frej Fyhrquist ◽  
Kimmo K Kontula ◽  
Timo P Hiltunen
Keyword(s):  
Uric Acid ◽  
Association Study ◽  
Serum Uric Acid ◽  
Acid Concentration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Uric Acid Concentration ◽  
Genome Wide ◽  
A Genome ◽  
Serum Uric Acid Concentration

scholarly journals A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Sven J. van der Lee ◽  
Maria J. Knol ◽  
Ganesh Chauhan ◽  
Claudia L. Satizabal ◽  
Albert Vernon Smith ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genetic Loci ◽  
Brain Volumes ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-Wide Association Study of Diabetogenic Adipose Morphology in the GENetics of Adipocyte Lipolysis (GENiAL) Cohort

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1085
Author(s):  
Veroniqa Lundbäck ◽  
Agné Kulyté ◽  
Peter Arner ◽  
Rona J. Strawbridge ◽  
Ingrid Dahlman
Keyword(s):  
Association Study ◽  
Candidate Genes ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Functional Evaluation ◽  
Small Interfering Rnas ◽  
Genetic Loci ◽  
Fat Depots ◽  
Genome Wide ◽  
A Genome

An increased adipocyte size relative to the size of fat depots, also denoted hypertrophic adipose morphology, is a strong risk factor for the future development of insulin resistance and type 2 diabetes. The regulation of adipose morphology is poorly understood. We set out to identify genetic loci associated with adipose morphology and functionally evaluate candidate genes for impact on adipocyte development. We performed a genome-wide association study (GWAS) in the unique GENetics of Adipocyte Lipolysis (GENiAL) cohort comprising 948 participants who have undergone abdominal subcutaneous adipose biopsy with a determination of average adipose volume and morphology. The GWAS identified 31 genetic loci displaying suggestive association with adipose morphology. Functional evaluation of candidate genes by small interfering RNAs (siRNA)-mediated knockdown in adipose-derived precursor cells identified six genes controlling adipocyte renewal and differentiation, and thus of potential importance for adipose hypertrophy. In conclusion, genetic and functional studies implicate a regulatory role for ATL2, ARHGEF10, CYP1B1, TMEM200A, C17orf51, and L3MBTL3 in adipose morphology by their impact on adipogenesis.

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