scholarly journals Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy

2004 ◽  
Vol 36 (6) ◽  
pp. 597-601 ◽  
Author(s):  
Joy Irobi ◽  
Katrien Van Impe ◽  
Pavel Seeman ◽  
Albena Jordanova ◽  
Ines Dierick ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Hot Spot ◽  
Small Heat Shock Protein ◽  
Motor Neuropathy ◽  
Heat Shock Protein 22

Mutant small heat shock protein B3 causes motor neuropathy: Utility of a candidate gene approach

Neurology ◽  
2010 ◽  
Vol 74 (6) ◽  
pp. 502-506 ◽  
Author(s):  
S. J. Kolb ◽  
P. J. Snyder ◽  
E. J. Poi ◽  
E. A. Renard ◽  
A. Bartlett ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Candidate Gene ◽  
Small Heat Shock Protein ◽  
Candidate Gene Approach ◽  
Motor Neuropathy

scholarly journals Distal hereditary motor neuropathy in Korean patients with a small heat shock protein 27 mutation

2008 ◽  
Vol 40 (3) ◽  
pp. 304 ◽  
Author(s):  
Ki Wha Chung ◽  
Sang-Beom Kim ◽  
Sun Young Cho ◽  
Su Jin Hwang ◽  
Sun Wha Park ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein ◽  
Heat Shock Protein 27 ◽  
Motor Neuropathy ◽  
Hereditary Motor ◽  
Korean Patients ◽  
Hereditary Motor Neuropathy

Regulation of Sam68 activity by small heat shock protein 22

2006 ◽  
Vol 99 (5) ◽  
pp. 1353-1362 ◽  
Author(s):  
Kameswara R. Badri ◽  
Suhasini Modem ◽  
Herve C. Gerard ◽  
Insia Khan ◽  
Mihir Bagchi ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein ◽  
Heat Shock Protein 22

Small heat-shock protein 22 mutated in autosomal dominant Charcot-Marie-Tooth disease type 2L

2004 ◽  
Vol 116 (3) ◽  
pp. 222-224 ◽  
Author(s):  
Bei-sha Tang ◽  
Guo-hua Zhao ◽  
Wei Luo ◽  
Kun Xia ◽  
Fang Cai ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Autosomal Dominant ◽  
Small Heat Shock Protein ◽  
Disease Type ◽  
Charcot Marie Tooth ◽  
Charcot Marie Tooth Disease ◽  
Heat Shock Protein 22 ◽  
Tooth Disease

Small heat shock protein 22 kDa can modulate the aggregation and liquid–liquid phase separation behavior of tau

2021 ◽  
Author(s):  
April L. Darling ◽  
Jan Dahrendorff ◽  
Stefan G. Creodore ◽  
Chad A. Dickey ◽  
Laura J. Blair ◽  
...  
Keyword(s):  
Phase Separation ◽  
Liquid Phase ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein ◽  
Liquid Phase Separation ◽  
Phase Separation Behavior ◽  
Heat Shock Protein 22 ◽  
Separation Behavior ◽  
Liquid Liquid Phase Separation

scholarly journals Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 114
Author(s):  
Xiaonan Sun ◽  
Sharadhi Siri ◽  
Amirah Hurst ◽  
Hongyu Qiu
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Molecular Mechanisms ◽  
Heart Diseases ◽  
Pressure Overload ◽  
Small Heat Shock Protein ◽  
Cardiac Metabolism ◽  
Vital Role ◽  
Post Translational Modification ◽  
Heat Shock Protein 22

Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets.

scholarly journals Hsp22 Deficiency Induces Age-Dependent Cardiac Dilation and Dysfunction by Impairing Autophagy, Metabolism, and Oxidative Response

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1550
Author(s):  
Wenqian Wu ◽  
Xiaonan Sun ◽  
Xiaomeng Shi ◽  
Lo Lai ◽  
Charles Wang ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Essential Role ◽  
Early Stage ◽  
Small Heat Shock Protein ◽  
Vital Role ◽  
Physiological Conditions ◽  
Age Related ◽  
And Function ◽  
Heat Shock Protein 22

Heat shock protein 22 (Hsp22) is a small heat shock protein predominantly expressed in skeletal and cardiac muscle. Previous studies indicate that Hsp22 plays a vital role in protecting the heart against cardiac stress. However, the essential role of Hsp22 in the heart under physiological conditions remains largely unknown. In this study, we used an Hsp22 knockout (KO) mouse model to determine whether loss of Hsp22 impairs cardiac growth and function with increasing age under physiological conditions. Cardiac structural and functional alterations at baseline were measured using echocardiography and invasive catheterization in Hsp22 KO mice during aging transition compared to their age-matched wild-type (WT) littermates. Our results showed that Hsp22 deletion induced progressive cardiac dilation along with declined function during the aging transition. Mechanistically, the loss of Hsp22 impaired BCL-2–associated athanogene 3 (BAG3) expression and its associated cardiac autophagy, undermined cardiac energy metabolism homeostasis and increased oxidative damage. This study showed that Hsp22 played an essential role in the non-stressed heart during the early stage of aging, which may bring new insight into understanding the pathogenesis of age-related dilated cardiomyopathy.

Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy

2013 ◽  
Vol 538 (1) ◽  
pp. 16-24 ◽  
Author(s):  
Victoria V. Nefedova ◽  
Maria V. Sudnitsyna ◽  
Sergei V. Strelkov ◽  
Nikolai B. Gusev
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Small Heat Shock Protein ◽  
Motor Neuropathy ◽  
Structure And Properties
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