Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia

2005 ◽  
Vol 37 (3) ◽  
pp. 265-274 ◽  
Author(s):  
Li Yu ◽  
Chunhui Liu ◽  
Jeff Vandeusen ◽  
Brian Becknell ◽  
Zunyan Dai ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Mouse Model ◽  
Tumor Suppressor Gene ◽  
Promoter Methylation ◽  
Global Assessment ◽  
Suppressor Gene ◽  
Human Leukemia ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

In Vitro and In Vivo Evidence That TSC-22 Is a Putative Tumor Suppressor Gene in Primary Murine and Human Leukemia.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 2211-2211
Author(s):  
Jianhua Yu ◽  
Li Yu ◽  
Bjoern Hackanson ◽  
Min Wei ◽  
Zachary Boyd ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Cell Lines ◽  
Suppressor Gene ◽  
Proximal Promoter ◽  
Human Leukemia ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

Abstract Transforming growth factor-β-stimulated clone-22 (TSC-22) is a gene that has been shown to be silenced in brain and prostate cancer, but its function and the mechanism responsible for this silencing are unknown. We used our model of spontaneous T-natural killer (NK) acute lymphoblastic leukemia (ALL) and discovered that the TSC-22 promoter was methylated resulting in absent expression in seven of eight cases of primary NK-T ALL, but not in cells from normal mice or mice with polyclonal expansion of T and NK cells. We found that TSC-22 was undetectable or minimally expressed in mouse lymphoma cell lines YAC-1 and EL-4 and human leukemia cell lines Jurkat and RPMI 8866, but treatment with the demethylation agent 5-aza-2′-deoxycytidine restored or increased TSC-22 expression. We mapped the TSC-22 promoter and discovered a CPG island in the proximal region and determined that its methylation was responsible for the decreased gene expression. Over-expression of TSC-22 slowed in vitro cell growth and resulted in a dramatic decrease of tumor size in vivo. Finally, TSC-22 expression was found to be absent or substantially reduced in human chronic lymphocytic leukemia and acute myeloid leukemia compared to normal human tissue. Collectively, our data indicate that TSC-22 is silenced via DNA methylation within its proximal promoter, and this silencing appears to contribute to its function as a putative tumor suppressor gene in leukemia. Silencing of TSC-22 can be reversed by 5-aza-2′-deoxycytidine, recently approved by the FDA for the treatment of myelodysplastic syndrome.

scholarly journals Assessment of Promoter Methylation Identifies PTCH as a Putative Tumor-suppressor Gene in Human CLL

2016 ◽  
Vol 36 (9) ◽  
pp. 4515-4520 ◽  
Author(s):  
INGO G.H SCHMIDT-WOLF ◽  
CHRISTOPH PLASS ◽  
JOHN C BYRD ◽  
KATHRIN FREVEL ◽  
TORSTEN PIETSCH ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Promoter Methylation ◽  
Suppressor Gene ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

Characterization of HRG22, a Human Homologue of the Putative Tumor Suppressor Gene HIC1

2001 ◽  
Vol 287 (2) ◽  
pp. 427-434 ◽  
Author(s):  
Sophie Deltour ◽  
Sébastien Pinte ◽  
Cateline Guérardel ◽  
Dominique Leprince
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Human Homologue ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

Developmental defects in gorlin syndrome related to a putative tumor suppressor gene on chromosome 9

Cell ◽  
1992 ◽  
Vol 69 (1) ◽  
pp. 111-117 ◽  
Author(s):  
Mae R. Gailani ◽  
Sherri J. Bale ◽  
David J. Leffell ◽  
John J. DiGiovanna ◽  
Gary L. Peck ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Chromosome 9 ◽  
Gorlin Syndrome ◽  
Developmental Defects ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

scholarly journals SHORT COMMUNICATION: Malignant conversion of human cells by antisense cDNA to a putative tumor suppressor gene

1996 ◽  
Vol 17 (8) ◽  
pp. 1751-1755 ◽  
Author(s):  
Dawei Li ◽  
Hua Yan ◽  
Jucheng Chen ◽  
Bruce C. Casto ◽  
Karl S. Theil ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Short Communication ◽  
Suppressor Gene ◽  
Human Cells ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor ◽  
Malignant Conversion

scholarly journals Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka

2018 ◽  
Vol 32 (2) ◽  
pp. 248-258 ◽  
Author(s):  
Janine Regneri ◽  
Barbara Klotz ◽  
Brigitta Wilde ◽  
Verena A. Kottler ◽  
Michael Hausmann ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Pigment Cells ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor

Sublocalization of putative tumor suppressor gene loci on chromosome arm 14q in neuroblastoma

1999 ◽  
Vol 26 (1) ◽  
pp. 40-46 ◽  
Author(s):  
Marco Theobald ◽  
Holger Christiansen ◽  
Anke Schmidt ◽  
Badrig Melekian ◽  
Nicole Wolkewitz ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Putative Tumor Suppressor Gene ◽  
Putative Tumor Suppressor ◽  
Chromosome Arm
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