scholarly journals Operant Sensation Seeking Engages Similar Neural Substrates to Operant Drug Seeking in C57 Mice

2009 ◽  
Vol 34 (7) ◽  
pp. 1685-1694 ◽  
Author(s):  
Christopher M Olsen ◽  
Danny G Winder
Keyword(s):  
Sensation Seeking ◽  
Neural Substrates ◽  
Drug Seeking

scholarly journals The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration

2021 ◽  
Author(s):  
◽  
Judith Bird
Keyword(s):  
Sensation Seeking ◽  
Instrumental Learning ◽  
Reaction Time Task ◽  
Novelty Seeking ◽  
Self Administration ◽  
Drug Seeking ◽  
Novel Environment ◽  
Trait Impulsivity ◽  
Rat Strain ◽  
Omission Rate

<p>It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, respectively. The aim of this thesis was to examine the relationship between these two traits and (1) the latency to acquisition and (2) maintenance (drug seeking) of 3,4-methylenedioxymethamphetamine (MDMA) self–administration. Impulsivity, measured as premature responding on the 5-choice serial reaction time task (5-CSRTT), and novelty seeking, measured as the locomotor response in a novel environment, were measured prior to self-administration. Due to characteristics of the rat strain and test equipment the 5-CSRTT was configurated in the first part of this study and modified from the standard version. Following training in this task animals were implanted with a siliastic catheter and were subsequently screened for their response to a novel environment prior to MDMA self-administration. Latency to acquisition was determined as the number of test sessions required to self-administer an initial criterion of 90 infusions of 1.0 mg/kg/infusion as well as an additional 150 infusions of 0.5 mg/kg/infusion MDMA. For some rats, the ability of MDMA (0, 5.0 or 10.0 mg/kg, IP) to produce drug seeking was subsequently measured and for others, impulsivity was again measured following self-administration. Novelty seeking predicted cocaine self-administration but was not significantly correlated with either the acquisition or drug-seeking measures of MDMA self-administration. Impulsivity was not significantly correlated with the latency to acquire self-administration of MDMA but was significantly and positively correlated with the magnitude of MDMA produced drug-seeking. Furthermore, MDMA self-administration produced a number of notable, but transient, deficits in the 5-CSRTT; there was an increase in omission rate and a delayed increase in premature responses in particular. These findings suggest that impulsivity, but not sensation seeking, might be a risk factor for the development of compulsive drug-seeking following withdrawal from MDMA self-administration. A surprising finding from this study was a high acquisition rate amongst rats that acquired the 5-CSRTT prior to self-administration. This difference was examined in a separate set of experiments. This effect could not be explained by an effect of handling, food restriction, or exposure to sweetened condensed milk and might possibly be due to differences in instrumental learning.</p>

Individual Differences in Neural Substrates of Sensation Seeking and Risky Choice Framing

2013 ◽  
Author(s):  
Valerie F. Reyna ◽  
Christina F. Chick ◽  
Jeremy D. Ojalehto ◽  
Rebecca B. Weldon ◽  
Jonathan C. Corbin ◽  
...  
Keyword(s):  
Individual Differences ◽  
Sensation Seeking ◽  
Neural Substrates ◽  
Risky Choice ◽  
Choice Framing

scholarly journals The Role of Trait Impulsivity and Novelty-Seeking as Predisposing Factors to the Acquisition and Reinstatement of MDMA Self-Administration

2021 ◽  
Author(s):  
◽  
Judith Bird
Keyword(s):  
Sensation Seeking ◽  
Instrumental Learning ◽  
Reaction Time Task ◽  
Novelty Seeking ◽  
Self Administration ◽  
Drug Seeking ◽  
Novel Environment ◽  
Trait Impulsivity ◽  
Rat Strain ◽  
Omission Rate

<p>It has been suggested that the response to novelty and impulsivity predict the latency to acquisition and maintenance of drug self-administration, respectively. The aim of this thesis was to examine the relationship between these two traits and (1) the latency to acquisition and (2) maintenance (drug seeking) of 3,4-methylenedioxymethamphetamine (MDMA) self–administration. Impulsivity, measured as premature responding on the 5-choice serial reaction time task (5-CSRTT), and novelty seeking, measured as the locomotor response in a novel environment, were measured prior to self-administration. Due to characteristics of the rat strain and test equipment the 5-CSRTT was configurated in the first part of this study and modified from the standard version. Following training in this task animals were implanted with a siliastic catheter and were subsequently screened for their response to a novel environment prior to MDMA self-administration. Latency to acquisition was determined as the number of test sessions required to self-administer an initial criterion of 90 infusions of 1.0 mg/kg/infusion as well as an additional 150 infusions of 0.5 mg/kg/infusion MDMA. For some rats, the ability of MDMA (0, 5.0 or 10.0 mg/kg, IP) to produce drug seeking was subsequently measured and for others, impulsivity was again measured following self-administration. Novelty seeking predicted cocaine self-administration but was not significantly correlated with either the acquisition or drug-seeking measures of MDMA self-administration. Impulsivity was not significantly correlated with the latency to acquire self-administration of MDMA but was significantly and positively correlated with the magnitude of MDMA produced drug-seeking. Furthermore, MDMA self-administration produced a number of notable, but transient, deficits in the 5-CSRTT; there was an increase in omission rate and a delayed increase in premature responses in particular. These findings suggest that impulsivity, but not sensation seeking, might be a risk factor for the development of compulsive drug-seeking following withdrawal from MDMA self-administration. A surprising finding from this study was a high acquisition rate amongst rats that acquired the 5-CSRTT prior to self-administration. This difference was examined in a separate set of experiments. This effect could not be explained by an effect of handling, food restriction, or exposure to sweetened condensed milk and might possibly be due to differences in instrumental learning.</p>

scholarly journals Strain and sex dependent effects of isolation housing relative to environmental enrichment on operant sensation seeking in mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Price E. Dickson ◽  
Guy Mittleman
Keyword(s):  
Chronic Stress ◽  
Recombinant Inbred ◽  
Sensation Seeking ◽  
Environmental Enrichment ◽  
Drugs Of Abuse ◽  
Drug Seeking ◽  
Gene By Environment Interactions ◽  
Primary Finding ◽  
Genetic Mechanisms ◽  
Recombinant Inbred Panel

AbstractSensation seeking is a multidimensional phenotype that predicts the development of drug addiction in humans and addiction-like drug seeking in rodents. Several lines of evidence suggest that chronic stress increases sensation seeking and addiction-like drug seeking through common genetic mechanisms. Discovery and characterization of these mechanisms would reveal how chronic stress interacts with the genome to influence sensation seeking and how drugs of abuse hijack these fundamental reward mechanisms to drive addiction. To this end, we tested the hypothesis that chronic isolation housing stress (relative to environmental enrichment) influences operant sensation seeking as a function of strain, sex, or their interaction. To determine if the BXD recombinant inbred panel could be used to identify genetic and epigenetic mechanisms underlying any identified gene-by-environment interactions, we used mice from the two BXD founder strains. Following 10 weeks of differential housing, we assessed operant sensation seeking using several reinforcement schedules. The primary finding from this study was that DBA/2J but not C57BL/6J mice were significantly vulnerable to an isolation-induced increase (relative to environmental enrichment) in sensation seeking during extinction when the sensory reward was no longer available; this effect was significantly more robust in females. These data reveal a previously unknown isolation-induced effect on extinction of operant sensation seeking that is sex-dependent, addiction-relevant, and that can be dissected using the BXD recombinant inbred panel.

Lessons From the Neural Bases of Speech and Voice

2011 ◽  
Vol 21 (1) ◽  
pp. 5-14
Author(s):  
Christy L. Ludlow
Keyword(s):  
Brain Networks ◽  
Neural Substrates ◽  
Voice Behavior ◽  
Therapeutic Approaches ◽  
Neural Bases ◽  
Sound Foundation ◽  
The Brain ◽  
Normal Speech

The premise of this article is that increased understanding of the brain bases for normal speech and voice behavior will provide a sound foundation for developing therapeutic approaches to establish or re-establish these functions. The neural substrates involved in speech/voice behaviors, the types of muscle patterning for speech and voice, the brain networks involved and their regulation, and how they can be externally modulated for improving function will be addressed.

Construct Validity of Sensation Seeking: A Psychometric Investigation

1999 ◽  
Vol 20 (3) ◽  
pp. 155-171 ◽  
Author(s):  
André Beauducel ◽  
Burkhard Brocke ◽  
Alexander Strobel ◽  
Anja Strobel
Keyword(s):  
Substance Use ◽  
Construct Validity ◽  
Psychometric Properties ◽  
Factor Structure ◽  
Sensation Seeking ◽  
German Version ◽  
Trait Theory ◽  
Multilevel Theory ◽  
Sensation Seeking Scale ◽  
Psychometric Investigation

Abstract: Zuckerman postulated a biopsychological multilevel theory of Sensation Seeking, which is part of a more complex multi-trait theory, the Alternative Five. The Sensation Seeking Scale Form V (SSS V) was developed for the measurement of Sensation Seeking. The process of validation of Sensation Seeking as part of a multilevel theory includes analyses of relations within and between several levels of measurement. The present study investigates validity and basic psychometric properties of a German version of the SSS V in a broader context of psychometric traits. - The 120 participants were mainly students. They completed the SSS V, the Venturesomeness- and Impulsiveness-Scales of the IVE, the BIS/BAS-Scales, the ZKPQ and the NEO-FFI. - The results reveal acceptable psychometric properties for the SSS V but with limitations with regard to factor structure. Indications for criterion validity were obtained by prediction of substance use by the subscales Dis and BS. The results of a MTMM analysis, especially the convergent validities of the SSS V were quite satisfying. On the whole, the results yielded sufficient support for the validity of the Sensation Seeking construct or the instrument respectively. They also point to desirable modifications.

Validation of the Short Dark Triad in a German Sample

2020 ◽  
pp. 1-12
Author(s):  
Caroline Wehner ◽  
Ulrike Maaß ◽  
Marius Leckelt ◽  
Mitja D. Back ◽  
Matthias Ziegler
Keyword(s):  
Sensation Seeking ◽  
Factor Model ◽  
Structural Models ◽  
Self Esteem ◽  
Dark Triad ◽  
Fit Indices ◽  
Nomological Network ◽  
Competitive Test ◽  
Three Factor ◽  
Behavioral Criteria

Abstract. The structure, correlates, and assessment of the Dark Triad are widely discussed in several fields of psychology. Based on the German version of the Short Dark Triad (SDT), we add to this by (a) providing a competitive test of existing structural models, (b) testing the nomological network, and (c) proposing an ultrashort 9-item version of the SDT (uSDT). A sample of N = 969 participants provided data on the SDT and a range of further measures. Our competitive test of five structural models revealed that fit indices and nomological network assumptions were best met in a three-factor model, with separate factors for psychopathy, Machiavellianism, and narcissism. The results provided an extensive overview of the raw, unique, and shared associations of Dark Triad dimensions with narcissism facets, sadism, impulsivity, self-esteem, sensation seeking, the Big Five, maladaptive personality traits, sociosexual orientation, and behavioral criteria. Finally, the uSDT exhibited satisfactory psychometric properties. The highest overlap in expected relations between SDT and uSDT, and convergent and discriminant measures was also found for the three-factor model. Our study underlines the utility of a three-factor model of the Dark Triad, extends findings on its nomological network, and provides an ultrashort instrument.

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