scholarly journals Influence of Excess Fat on Cardiac Morphology and Function: Study in Uncomplicated Obesity

2002 ◽  
Vol 10 (8) ◽  
pp. 767-773 ◽  
Author(s):  
Gianluca Iacobellis ◽  
Maria Cristina Ribaudo ◽  
Gaetano Leto ◽  
Alessandra Zappaterreno ◽  
Elio Vecci ◽  
...  
Keyword(s):  
Cardiac Morphology ◽  
Function Study ◽  
And Function

scholarly journals Evaluation of prenatal changes in fetal cardiac morphology and function in maternal diabetes mellitus using a novel fetal speckle-tracking analysis: a prospective cohort study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Dong Wang ◽  
Caixia Liu ◽  
Xinyu Liu ◽  
Ying Zhang ◽  
Yu Wang
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Pregnant Women ◽  
Gestational Age ◽  
Speckle Tracking ◽  
Control Group ◽  
Second Trimester ◽  
Cardiac Morphology ◽  
Sphericity Index ◽  
And Function

Abstract Background Due to metabolic changes in the second trimester and the increasing number of pregnant women with obesity and advanced maternal age, the incidence of gestational diabetes mellitus (GDM) remains high. This study aimed to evaluate the effects of GDM on fetal cardiac morphology and function, and to determine whether these changes increase with increasing estimated fetal weight (EFW). Methods Fifty-eight women with GDM (GDM group) and 58 women with a healthy pregnancy (control group) were included in this prospective observational cohort study. Each group included subgroups of 31 pregnant women with a gestational age between 24+0 weeks and 27+6 weeks as well as 27 pregnant women with a gestational age between 28+0 weeks and 40+0 weeks. For all fetuses, a cine of 2–3 s in the four-chamber view was obtained, and online speckle-tracking analysis was performed using the GE Automatic Fetal Heart Assessment Tool (fetal HQ; General Electric Healthcare Ultrasound, Zipf, Austria) to measure the global sphericity index (GSI), global longitudinal strain (GLS), fractional area change (FAC), 24-segment sphericity index (SI), and 24-segment end-diastolic diameter of the left ventricle (LV) and right ventricle (RV). Data were analyzed using the independent t-test and Wilcoxon rank-sum test, as applicable. Results The GDM group (mean HbA1c value was 5.3 ± 0.57 mmol/L) showed a lower GSI value than the control group (1.21 vs. 1.27, P = 0.000), which indicated a rounder shape of the heart. In addition, fetuses in the GDM group demonstrated significant impairment in cardiac function compared to those in the control group (LV-GLS: -18.26% vs. -22.70%, RV-GLS: -18.52% vs. -22.74%, LV-FAC: 35.30% vs. 42.36%, RV-FAC: 30.89% vs. 36.80%; P = 0.000 for all). Subgroup analyses according to gestational age (24+0–27+6 weeks and 28+0–40+0 weeks) showed that the statistical differences were retained between the GDM and control groups in each subgroup. Conclusions Fetuses of women with GDM present with signs of biventricular systolic dysfunction according to deformation analysis using fetal HQ. Additionally, the heart had a rounder shape in the GDM group than in the control group. This study showed that fetal HQ can be used to assess fetal cardiac morphology and function easily and quickly, and the effects of GDM on fetal cardiac morphology and function appeared from the second trimester. Thus, whether earlier and stricter clinical intervention was necessary remained to be further studied. Furthermore, future studies will need to supplement the effects of blood glucose levels on GLS, FAC, GSI, and 24-segment SI. Additionally, the long-term follow-up after birth should also be improved to observe the influence of changes in the indicators on the prognosis.

Cardiac Morphology and Function in Preterm Growth Restricted Infants: Relevance for Clinical Sequelae

2017 ◽  
Vol 188 ◽  
pp. 128-134.e2 ◽  
Author(s):  
Arvind Sehgal ◽  
Beth J. Allison ◽  
Stella M. Gwini ◽  
Suzanne L. Miller ◽  
Graeme R. Polglase
Keyword(s):  
Cardiac Morphology ◽  
And Function

Alterations in Cardiac Morphology and Function in Elite Multi-Disciplinary Athletes

1999 ◽  
Vol 20 (04) ◽  
pp. 222-226 ◽  
Author(s):  
G. Whyte ◽  
S. Sharma ◽  
K. George ◽  
W. McKenna
Keyword(s):  
Cardiac Morphology ◽  
And Function

Abstract 228: Alterations of Cardiac Morphology and Function Caused by Cardio-Thoracic Surgery in Small Animal Models of Heart Disease

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Peter Nordbeck ◽  
Leoni Bönhof ◽  
Karl-Heinz Hiller ◽  
Sabine Voll ◽  
Paula Arias ◽  
...  
Keyword(s):  
Body Weight ◽  
Heart Disease ◽  
Animal Models ◽  
Right Ventricular ◽  
Small Animal ◽  
Cardiac Morphology ◽  
Small Animal Models ◽  
And Function

Background: Surgical procedures in small animal models of heart disease, such as artificial ligation of the coronary arteries for experimental myocardial infarction, can evoke alterations in cardiac morphology and function. Such alterations might induce artificial early or long term effects in vivo that might account for a significant bias in basic cardiovascular research, and, therefore, could potentially question the meaning of respective studies in small animal models of heart disease. Methods: Female Wistar rats were matched for weight and distributed to sham left coronary artery ligation or untreated control. Cardiac parameters were then investigated in vivo by high-field MRI over time after the surgical procedure, determining left and right ventricular morphology and function. Additionally, the time course of several metabolic and inflammatory blood parameters was determined. Results: Rats after sham surgery showed a lower body weight for up to 8 weeks after the intervention compared to healthy controls. Left and right ventricular morphology and function were not different in absolute measures in both groups 1 week after surgery. However, there was a confined difference in several cardiac parameters normalized to the body weight (bw), such as myocardial mass (2.19±0.30/0.83±0.13 vs. 1.85±0.22/0.70±0.07 mg left/right per g bw, p<0.05), or enddiastolic ventricular volume (1.31±0.36/1.21±0.31 vs. 1.14±0.20/1.07±0.17 µl left/right per g bw, p<0.05). Vice versa, after 8 weeks, cardiac masses, volumes, and output showed a trend for lower values in the sham operated rats compared to the controls in absolute measures (782.2±57.2/260.2±33.2 vs. 805.9±84.8/310.4±48.5 mg, p<0.05 for left/right ventricular mass), but not normalized to body weight. Matching these findings, blood testing revealed prolonged metabolic and inflammatory changes after surgery not related to cardiac disease. Conclusion: There is a small distinct impact of cardio-thoracic surgical procedures on the global integrity of the organism, which in the long term also includes circumscribed repercussions on cardiac morphology and function. This impact has to be considered when analyzing data from respective studies and transferring the findings to conditions in patients.

Impact of pectus excavatum on cardiac morphology and function according to the site of maximum compression: effect of physical exertion and respiratory cycle

2019 ◽  
Vol 21 (1) ◽  
pp. 77-84
Author(s):  
Gaston A Rodriguez-Granillo ◽  
Ignacio M Raggio ◽  
Alejandro Deviggiano ◽  
Gaston Bellia-Munzon ◽  
Carlos Capunay ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Diastolic Function ◽  
Pectus Excavatum ◽  
Multimodality Imaging ◽  
Left Ventricular ◽  
Cardiac Morphology ◽  
Maximum Compression ◽  
Cardiac Compression ◽  
And Function ◽  
Septal Motion

Abstract Aims Previous studies have demonstrated diverse cardiac manifestations in patients with pectus excavatum (PEX), although mostly addressing morphological or physiological impact as separate findings. Using multimodality imaging, we evaluated the impact of PEX on cardiac morphology and function according to the site of maximum compression, and the effect of exertion and breathing. Methods and results All patients underwent chest computed tomography, cardiac magnetic resonance (CMR), and stress echocardiography (echo) in order to establish surgical candidacy. We evaluated diastolic function and trans-tricuspid gradient during stress (echo); and systolic function and respiratory-related septal wall motion abnormalities (CMR). Patients were classified according to the site of cardiac compression as type 0 (without cardiac compression); type 1 (right ventricle); and type 2 [right ventricle and atrioventricular (AV) groove]. Fifty-nine patients underwent multimodality imaging, with a mean age of 19.5 ± 5.9 years. Compared with a sex and age matched control group, peak exercise capacity was lower in patients with PEX (8.4 ± 2.0 METs vs. 15.1 ± 4.6 METs, P &lt; 0.0001). At stress, significant differences were found between groups regarding left ventricular E/A (P = 0.004) and e/a ratio (P = 0.005), right ventricular E/A ratio (P = 0.03), and trans-tricuspid gradient (P = 0.001). At CMR, only 9 (15%) patients with PEX had normal septal motion, whereas 17 (29%) had septal flattening during inspiration. Septal motion abnormalities were significantly related to the cardiac compression classification (P &lt; 0.0001). Conclusions The present study demonstrated that patients with PEX, particularly those with compression affecting the right ventricle and AV groove, manifest diverse cardiac abnormalities that are mostly related to exertion, inspiration, and diastolic function.

Molecular characteristics and function study of TNF receptor-associated factor 5 from grouper (Epinephelus coioides)

2019 ◽  
Vol 87 ◽  
pp. 730-736 ◽  
Author(s):  
Man Yang ◽  
Rui Han ◽  
Lu-Yun Ni ◽  
Xiao-Chun Luo ◽  
An-Xing Li ◽  
...  
Keyword(s):  
Molecular Characteristics ◽  
Epinephelus Coioides ◽  
Tnf Receptor ◽  
Associated Factor ◽  
Function Study ◽  
And Function

Association of vaspin gene polymorphisms with coronary artery disease in Chinese population and function study

2013 ◽  
Vol 415 ◽  
pp. 233-238 ◽  
Author(s):  
Hai Ling Li ◽  
Hong Li Zhang ◽  
Wei Xia Jian ◽  
Qi Li ◽  
Wen Hui Peng ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Function Study ◽  
Artery Disease ◽  
And Function

scholarly journals Structure and function study of paramyxovirus fusion protein heptad repeat peptides

2005 ◽  
Vol 436 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Xiao-Jia Wang ◽  
Ya-Duo Bai ◽  
Guo-Zhong Zhang ◽  
Ji-Xun Zhao ◽  
Ming Wang ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Structure And Function ◽  
Heptad Repeat ◽  
Function Study ◽  
And Function
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