scholarly journals The bi- (or multi-) phasic response of cardiac remodelling to endurance exercise related to the article: ‘From talented child to elite athlete: The development of cardiac morphology and function in a cohort of endurance athletes from age 12 to 18’ by Bjerring and colleagues

2020 ◽  
pp. 204748732092924
Author(s):  
Martin Burtscher
Keyword(s):  
Endurance Exercise ◽  
Elite Athlete ◽  
Endurance Athletes ◽  
Cardiac Remodelling ◽  
Phasic Response ◽  
Cardiac Morphology ◽  
And Function

scholarly journals Evaluation of prenatal changes in fetal cardiac morphology and function in maternal diabetes mellitus using a novel fetal speckle-tracking analysis: a prospective cohort study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Dong Wang ◽  
Caixia Liu ◽  
Xinyu Liu ◽  
Ying Zhang ◽  
Yu Wang
Keyword(s):  
Diabetes Mellitus ◽  
Cohort Study ◽  
Pregnant Women ◽  
Gestational Age ◽  
Speckle Tracking ◽  
Control Group ◽  
Second Trimester ◽  
Cardiac Morphology ◽  
Sphericity Index ◽  
And Function

Abstract Background Due to metabolic changes in the second trimester and the increasing number of pregnant women with obesity and advanced maternal age, the incidence of gestational diabetes mellitus (GDM) remains high. This study aimed to evaluate the effects of GDM on fetal cardiac morphology and function, and to determine whether these changes increase with increasing estimated fetal weight (EFW). Methods Fifty-eight women with GDM (GDM group) and 58 women with a healthy pregnancy (control group) were included in this prospective observational cohort study. Each group included subgroups of 31 pregnant women with a gestational age between 24+0 weeks and 27+6 weeks as well as 27 pregnant women with a gestational age between 28+0 weeks and 40+0 weeks. For all fetuses, a cine of 2–3 s in the four-chamber view was obtained, and online speckle-tracking analysis was performed using the GE Automatic Fetal Heart Assessment Tool (fetal HQ; General Electric Healthcare Ultrasound, Zipf, Austria) to measure the global sphericity index (GSI), global longitudinal strain (GLS), fractional area change (FAC), 24-segment sphericity index (SI), and 24-segment end-diastolic diameter of the left ventricle (LV) and right ventricle (RV). Data were analyzed using the independent t-test and Wilcoxon rank-sum test, as applicable. Results The GDM group (mean HbA1c value was 5.3 ± 0.57 mmol/L) showed a lower GSI value than the control group (1.21 vs. 1.27, P = 0.000), which indicated a rounder shape of the heart. In addition, fetuses in the GDM group demonstrated significant impairment in cardiac function compared to those in the control group (LV-GLS: -18.26% vs. -22.70%, RV-GLS: -18.52% vs. -22.74%, LV-FAC: 35.30% vs. 42.36%, RV-FAC: 30.89% vs. 36.80%; P = 0.000 for all). Subgroup analyses according to gestational age (24+0–27+6 weeks and 28+0–40+0 weeks) showed that the statistical differences were retained between the GDM and control groups in each subgroup. Conclusions Fetuses of women with GDM present with signs of biventricular systolic dysfunction according to deformation analysis using fetal HQ. Additionally, the heart had a rounder shape in the GDM group than in the control group. This study showed that fetal HQ can be used to assess fetal cardiac morphology and function easily and quickly, and the effects of GDM on fetal cardiac morphology and function appeared from the second trimester. Thus, whether earlier and stricter clinical intervention was necessary remained to be further studied. Furthermore, future studies will need to supplement the effects of blood glucose levels on GLS, FAC, GSI, and 24-segment SI. Additionally, the long-term follow-up after birth should also be improved to observe the influence of changes in the indicators on the prognosis.

Cardiac Morphology and Function in Preterm Growth Restricted Infants: Relevance for Clinical Sequelae

2017 ◽  
Vol 188 ◽  
pp. 128-134.e2 ◽  
Author(s):  
Arvind Sehgal ◽  
Beth J. Allison ◽  
Stella M. Gwini ◽  
Suzanne L. Miller ◽  
Graeme R. Polglase
Keyword(s):  
Cardiac Morphology ◽  
And Function

Alterations in Cardiac Morphology and Function in Elite Multi-Disciplinary Athletes

1999 ◽  
Vol 20 (04) ◽  
pp. 222-226 ◽  
Author(s):  
G. Whyte ◽  
S. Sharma ◽  
K. George ◽  
W. McKenna
Keyword(s):  
Cardiac Morphology ◽  
And Function

Abstract 228: Alterations of Cardiac Morphology and Function Caused by Cardio-Thoracic Surgery in Small Animal Models of Heart Disease

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Peter Nordbeck ◽  
Leoni Bönhof ◽  
Karl-Heinz Hiller ◽  
Sabine Voll ◽  
Paula Arias ◽  
...  
Keyword(s):  
Body Weight ◽  
Heart Disease ◽  
Animal Models ◽  
Right Ventricular ◽  
Small Animal ◽  
Cardiac Morphology ◽  
Small Animal Models ◽  
And Function

Background: Surgical procedures in small animal models of heart disease, such as artificial ligation of the coronary arteries for experimental myocardial infarction, can evoke alterations in cardiac morphology and function. Such alterations might induce artificial early or long term effects in vivo that might account for a significant bias in basic cardiovascular research, and, therefore, could potentially question the meaning of respective studies in small animal models of heart disease. Methods: Female Wistar rats were matched for weight and distributed to sham left coronary artery ligation or untreated control. Cardiac parameters were then investigated in vivo by high-field MRI over time after the surgical procedure, determining left and right ventricular morphology and function. Additionally, the time course of several metabolic and inflammatory blood parameters was determined. Results: Rats after sham surgery showed a lower body weight for up to 8 weeks after the intervention compared to healthy controls. Left and right ventricular morphology and function were not different in absolute measures in both groups 1 week after surgery. However, there was a confined difference in several cardiac parameters normalized to the body weight (bw), such as myocardial mass (2.19±0.30/0.83±0.13 vs. 1.85±0.22/0.70±0.07 mg left/right per g bw, p<0.05), or enddiastolic ventricular volume (1.31±0.36/1.21±0.31 vs. 1.14±0.20/1.07±0.17 µl left/right per g bw, p<0.05). Vice versa, after 8 weeks, cardiac masses, volumes, and output showed a trend for lower values in the sham operated rats compared to the controls in absolute measures (782.2±57.2/260.2±33.2 vs. 805.9±84.8/310.4±48.5 mg, p<0.05 for left/right ventricular mass), but not normalized to body weight. Matching these findings, blood testing revealed prolonged metabolic and inflammatory changes after surgery not related to cardiac disease. Conclusion: There is a small distinct impact of cardio-thoracic surgical procedures on the global integrity of the organism, which in the long term also includes circumscribed repercussions on cardiac morphology and function. This impact has to be considered when analyzing data from respective studies and transferring the findings to conditions in patients.

scholarly journals Cardiac remodelling and exercise: What happens with ultra-endurance exercise?

2020 ◽  
Vol 27 (14) ◽  
pp. 1464-1466
Author(s):  
Cameron Dockerill ◽  
Winok Lapidaire ◽  
Adam J Lewandowski ◽  
Paul Leeson
Keyword(s):  
Endurance Exercise ◽  
Cardiac Remodelling ◽  
Ultra Endurance

Impact of pectus excavatum on cardiac morphology and function according to the site of maximum compression: effect of physical exertion and respiratory cycle

2019 ◽  
Vol 21 (1) ◽  
pp. 77-84
Author(s):  
Gaston A Rodriguez-Granillo ◽  
Ignacio M Raggio ◽  
Alejandro Deviggiano ◽  
Gaston Bellia-Munzon ◽  
Carlos Capunay ◽  
...  
Keyword(s):  
Right Ventricle ◽  
Diastolic Function ◽  
Pectus Excavatum ◽  
Multimodality Imaging ◽  
Left Ventricular ◽  
Cardiac Morphology ◽  
Maximum Compression ◽  
Cardiac Compression ◽  
And Function ◽  
Septal Motion

Abstract Aims Previous studies have demonstrated diverse cardiac manifestations in patients with pectus excavatum (PEX), although mostly addressing morphological or physiological impact as separate findings. Using multimodality imaging, we evaluated the impact of PEX on cardiac morphology and function according to the site of maximum compression, and the effect of exertion and breathing. Methods and results All patients underwent chest computed tomography, cardiac magnetic resonance (CMR), and stress echocardiography (echo) in order to establish surgical candidacy. We evaluated diastolic function and trans-tricuspid gradient during stress (echo); and systolic function and respiratory-related septal wall motion abnormalities (CMR). Patients were classified according to the site of cardiac compression as type 0 (without cardiac compression); type 1 (right ventricle); and type 2 [right ventricle and atrioventricular (AV) groove]. Fifty-nine patients underwent multimodality imaging, with a mean age of 19.5 ± 5.9 years. Compared with a sex and age matched control group, peak exercise capacity was lower in patients with PEX (8.4 ± 2.0 METs vs. 15.1 ± 4.6 METs, P &lt; 0.0001). At stress, significant differences were found between groups regarding left ventricular E/A (P = 0.004) and e/a ratio (P = 0.005), right ventricular E/A ratio (P = 0.03), and trans-tricuspid gradient (P = 0.001). At CMR, only 9 (15%) patients with PEX had normal septal motion, whereas 17 (29%) had septal flattening during inspiration. Septal motion abnormalities were significantly related to the cardiac compression classification (P &lt; 0.0001). Conclusions The present study demonstrated that patients with PEX, particularly those with compression affecting the right ventricle and AV groove, manifest diverse cardiac abnormalities that are mostly related to exertion, inspiration, and diastolic function.

Physiological cardiac remodelling in response to endurance exercise training: cellular and molecular mechanisms

Heart ◽  
2011 ◽  
Vol 98 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Georgina M Ellison ◽  
Cheryl D Waring ◽  
Carla Vicinanza ◽  
Daniele Torella
Keyword(s):  
Exercise Training ◽  
Endurance Exercise ◽  
Molecular Mechanisms ◽  
Cardiac Remodelling ◽  
Endurance Exercise Training

LEFT VENTRICULAR STRUCTURE AND FUNCTION IN ULTRA-ENDURANCE ATHLETES

1985 ◽  
Vol 17 (2) ◽  
pp. 203
Author(s):  
Pamela S. Douglas ◽  
Douglas W. B. Hiller ◽  
Mary L. OʼToole ◽  
Nathaniel Reichek
Keyword(s):  
Left Ventricular ◽  
Structure And Function ◽  
Endurance Athletes ◽  
Left Ventricular Structure ◽  
Ventricular Structure ◽  
And Function ◽  
Ultra Endurance

scholarly journals P784 Cardiac remodelling in elite rowers - insights from novel echocardiographic techniques

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
G Kleinnibbelink ◽  
N M Panhuyzen-Goedkoop ◽  
H G Hulshof ◽  
A P J Van Dijk ◽  
K P George ◽  
...  
Keyword(s):  
Exercise Training ◽  
Elite Athlete ◽  
Left Ventricular ◽  
Cardiac Remodelling ◽  
Physiological Adaptation ◽  
Training Volume ◽  
Short Term ◽  
Apical Rotation ◽  
Elite Rowers ◽  
The Impact

Abstract Funding Acknowledgements No financial support Background Chronic exercise training leads to cardiac remodelling; the so-called Athlete’s Heart. Previous studies are often limited by a cross-sectional design whilst longitudinal training studies are often constrained to the assessment of non-athletes. Echocardiography provides comprehensive assessment of mechanics and may give additional insight into short-term changes in training volume in the elite athlete. Purpose To examine the impact of a short-term (9 months) increase in training volume on cardiac structure and mechanics in elite international competing rowers. Methods As part of the work-up to the 2012 Olympic Games, twenty-seven elite rowers (26.4 ± 3.7 years, 19 male) underwent baseline echocardiography prior to and post (9-months) a planned increase in training volume. Conventional echocardiographic indices including mechanics of all cardiac chambers were assessed. Results In response to increased training volume, there was a significant increase in left ventricular (LV) size (IVSd 9.2 ± 1.2 to 9.7 ± 1.1 mm, p = 0.001; PWd 8.3 ± 1.3 to 8.7 ± 1.4 mm, p = 0.013), LVIDd (56.5 ± 4.6 to 57.9 ± 4.2 mm, p = 0.001), and LVMi (90.2 ± 17.8 to 100.8 ± 17.1 g/m2, p = 0.000), see table. There was a significant increase in LV twist (9.2 ± 4.5 to 11.2 ± 4.7 °, p = 0.04; basal rotation -4.4 ± 3.1 to -4.5 ± 3.4 °, p = 0.84; apical rotation 5.8 ± 3.4 to 7.1 ± 3.7 °, p = 0.011), see figure, however, there were no changes in any other conventional indices of function or any other cardiac mechanics. There was a significant increase in left atrial (LA) volume (58.8 ± 15.2 to 65.3 ± 17.6 mm, p = 0.01) whilst no changes were observed in right heart structure. Conclusion An increase in exercise training volume in elite rowers across 9-months induced mild balanced structural remodelling of the LV and LA with a concomitant increase in LV twist. Contradictory to findings in non-athletes, there was no increase in right ventricular or atrial structure or function which may be representative of the elite athlete status and possibly already at threshold for physiological adaptation. Abstract P784 Figure.

Sign in / Sign up

Export Citation Format

Share Document