scholarly journals Role of clusterin/progranulin in toluene diisocyanate-induced occupational asthma

2018 ◽  
Vol 50 (5) ◽  
pp. 1-10 ◽  
Author(s):  
Gil-Soon Choi ◽  
Hoang Kim Tu Trinh ◽  
Eun-Mi Yang ◽  
Young-Min Ye ◽  
Yoo Seob Shin ◽  
...  
Keyword(s):  
Occupational Asthma ◽  
Toluene Diisocyanate

Role of Tumor Necrosis Factor in Toluene Diisocyanate Asthma

2002 ◽  
Vol 27 (4) ◽  
pp. 396-405 ◽  
Author(s):  
Joanna M. Matheson ◽  
Ranulfo Lemus ◽  
Robert W. Lange ◽  
Meryl H. Karol ◽  
Michael I. Luster
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Toluene Diisocyanate ◽  
Necrosis Factor

Serum ferritin and transferrin levels are not serologic markers of toluene diisocyanate–induced occupational asthma

2010 ◽  
Vol 125 (3) ◽  
pp. 762-764 ◽  
Author(s):  
Joaquín Sastre ◽  
Beatriz Sastre ◽  
Mar Fernández-Nieto ◽  
Ignacio Pérez-Camo ◽  
José Javier Sánchez ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Occupational Asthma ◽  
Toluene Diisocyanate ◽  
Serologic Markers

The HLA DRB1*1501-DQB1*0602-DPB1*0501 Haplotype Is a Risk Factor for Toluene Diisocyanate-Induced Occupational Asthma

2009 ◽  
Vol 150 (2) ◽  
pp. 156-163 ◽  
Author(s):  
Jeong-Hee Choi ◽  
Kyung-Wha Lee ◽  
Cheol-Woo Kim ◽  
Choon-Sik Park ◽  
Hyun-Young Lee ◽  
...  
Keyword(s):  
Risk Factor ◽  
Occupational Asthma ◽  
Toluene Diisocyanate

The role of IL 4, 5, 10, 13 and 8 Values in The Early Detection of Occupational Asthma Disease

2021 ◽  
Author(s):  
Mehmet Fatih Elverisli ◽  
Pınar Yıldız Gülhan ◽  
Merve Erçelik ◽  
İbrahim Ethem Şahin ◽  
Ege Güleç Balbay ◽  
...  
Keyword(s):  
Early Detection ◽  
Occupational Asthma

scholarly journals Micro and nanocomposites of polybutadienebased polyurethane liners with mineral fillers and nanoclay: thermal and mechanical properties

2017 ◽  
Vol 15 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Pablo Ross ◽  
Germán Escobar ◽  
Guillermo Sevilla ◽  
Javier Quagliano
Keyword(s):  
Thermal Properties ◽  
Polymer Chains ◽  
Toluene Diisocyanate ◽  
Mechanical And Thermal Properties ◽  
Scanning Calorimetry ◽  
Elongation At Break ◽  
Force Microscopy ◽  
Atomic Force ◽  
Mineral Fillers

AbstractMicro and nanocomposites of hydroxyl terminated polybutadiene (HTPB)-based polyurethanes (NPU) were obtained using five mineral fillers and Cloisite 20A nanoclay, respectively. Samples were prepared by the reaction of HTPB polyol and toluene diisocyanate (TDI), and the chain was further extended with glyceryl monoricinoleate to produce the final elastomeric polyurethanes. Mechanical and thermal properties were studied, showing that mineral fillers (20%w/w) significantly increased tensile strength, in particular nanoclay (at 5% w/w). When nanoclay-polymer dispersion was modified with a silane and hydantoin-bond promoter, elongation at break was significantly increased with respect to NPU with C20A. Thermal properties measured by differential scanning calorimetry (DSC) were not significantly affected in any case. The molecular structure of prepared micro and nanocomposites was confirmed by Fourier transform infrared (FTIR) spectroscopy and Raman spectroscopy. Interaction of fillers with polymer chains is discussed, considering the role of silanes in compatibilization of hydrophilic mineral fillers and hydrophobic polymer. The functionalization of nanoclay with HMDS silane was confirmed using FTIR. Microstructure of NPU with C20A nanoclay was confirmed by Atomic Force Microscopy (AFM).

scholarly journals Practical learnings from an epidemiology study on TDI-related occupational asthma: Part I—Cumulative exposure is not a good indicator of risk

2020 ◽  
Vol 36 (11) ◽  
pp. 876-884 ◽  
Author(s):  
Patrick M Plehiers ◽  
Anne H Chappelle ◽  
Mark W Spence
Keyword(s):  
Occupational Asthma ◽  
Weighted Average ◽  
Toluene Diisocyanate ◽  
Cumulative Exposure ◽  
Respiratory Protection ◽  
Epidemiology Study ◽  
Average Value ◽  
Asthma Incidence ◽  
Anonymized Data ◽  
Epidemiology Studies

The anonymized data of an epidemiology study on incidence of toluene diisocyanate (TDI)-related occupational asthma in three US-based TDI production facilities have been reanalyzed to identify where to best focus exposure reduction efforts in industrial practice to reduce the risk of sensitization to TDI. Since the induction of sensitization has sometimes been attributed to cumulative exposure, this relationship was examined first. Gross cumulative exposure values (i.e. not taking into account whether respiratory protection was used or not) and net cumulative exposure values (i.e. accounting for the use of respiratory protection) per participant were calculated based on the duration of their study participation and the average time-weighted average value of the exposure group to which they belonged. These two sets of cumulative exposure data were compared with asthma incidence using logistic regression. Incidence was zero among workers who rarely come into contact with open plant systems (e.g. during maintenance or spills). Notwithstanding, no statistically significant relationship between asthma incidence and either gross or net cumulative exposure could be determined. This is shown to be consistent with the results of several other epidemiology studies on TDI-related occupational asthma. In conclusion, cumulative exposure values are not a good indicator of the risk of developing TDI-related occupational asthma.

scholarly journals Barriers to the Recognition and Reporting of Occupational Asthma by Canadian Pulmonologists

2011 ◽  
Vol 18 (2) ◽  
pp. 90-96 ◽  
Author(s):  
Anu Parhar ◽  
Catherine Lemiere ◽  
Jeremy R Beach
Keyword(s):  
Occupational Asthma ◽  
Postal Questionnaire ◽  
Perceived Barriers ◽  
Work Related ◽  
Inhalation Challenge ◽  
Patient Concerns ◽  
Analogue Scales ◽  
Possible Cause ◽  
New Onset

BACKGROUND: Occupational asthma is a common, but probably under-recognized problem.OBJECTIVE: To identify the factors that suggest work-related asthma when a pulmonologist encounters an adult patient with new-onset asthma, and to identify the barriers to recognizing and reporting such cases.METHODS: A postal questionnaire was sent to all pulmonologists in Canada. The questionnaire asked participants to respond to several questions about recognizing, diagnosing and reporting occupational asthma. Answers were scored using visual analogue scales.RESULTS: A total of 201 eligible responses were received from 458 pulmonologists. Pulmonologists identified that the most important factor in initially considering the role of work in occupational asthma was having seen others affected at the same workplace, or exposed to the same agent. Important perceived barriers to considering a diagnosis of occupational asthma were physicians’ low awareness, lack of knowledge and time. The most important barriers to reporting cases were the pulmonologists’ perceived patient concerns regarding job security and income. Quebec pulmonologists generally perceived barriers to recognizing and reporting occupational asthma to be less important, and believed that the use of specific inhalation challenge was more important in considering a diagnosis.CONCLUSIONS: Pulmonologists most readily recognized occupational asthma caused by a substance or process that they previously encountered as a possible cause of asthma. Time constraints and knowledge may hamper their ability to recognize occupational asthma. Concerns regarding the effect of the diagnosis on the patient’s job and income may discourage reporting.

scholarly journals Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States

2017 ◽  
Vol 59 ◽  
pp. S13-S21 ◽  
Author(s):  
Laura D. Cassidy ◽  
Brent Doney ◽  
Mei Lin Wang ◽  
Laura Kurth ◽  
Patrick R. Conner ◽  
...  
Keyword(s):  
United States ◽  
Occupational Asthma ◽  
The United States ◽  
Toluene Diisocyanate ◽  
Medical Monitoring
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