Relationships between circulating 25(OH) vitamin D, leptin levels and visceral adipose tissue volume: results from a 1-year lifestyle intervention program in men with visceral obesity

2019 ◽  
Vol 44 (2) ◽  
pp. 280-288 ◽  
Author(s):  
Anne Gangloff ◽  
Jean Bergeron ◽  
Isabelle Lemieux ◽  
Angelo Tremblay ◽  
Paul Poirier ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Lifestyle Intervention ◽  
Visceral Adipose Tissue ◽  
Intervention Program ◽  
Visceral Obesity ◽  
Lifestyle Intervention Program ◽  
Adipose Tissue Volume ◽  
25 Oh Vitamin D ◽  
Visceral Adipose

scholarly journals Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue

2020 ◽  
Author(s):  
Luisa Fernández-Chirino ◽  
Neftali Eduardo Antonio-Villa ◽  
Arsenio Vargas-Vázquez ◽  
Paloma Almeda-Valdés ◽  
Donají Gómez-Velasco ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Adipose Tissue ◽  
Uric Acid ◽  
Serum Uric Acid ◽  
Visceral Adipose Tissue ◽  
Visceral Obesity ◽  
Causal Mechanism ◽  
Mediation Analyses ◽  
Bidirectional Relationship ◽  
Visceral Adipose

BACKGROUND: Serum uric acid (SUA) has a relationship with cardiometabolic conditions such as insulin resistance (IR) and visceral adipose tissue (VAT) accumulation. Here, we aimed to clarify the nature of this relationship and the underlying causality mechanism. METHODS: We conducted a population-based cross-sectional study comprising 8,504 subjects joining both NHANES 2003-2004 and 2011-2012 cycles and ENSANUT Medio Camino 2016. We performed mixed effects linear regression models using HOMA2-IR, adipoIR, and METS-VF as indicators of IR and VAT accumulation. Furthermore, we performed mediation analyses to assess a potential causal mechanism and ROC curves to establish cut-off points for identification of IR and visceral obesity using SUA. Finally, with an additional dataset comprised of 226 subjects with both euglycemic hyperinsulinemic clamp (EHC) and dual X-ray absorptiometry (DXA) measurements for IR and VAT accumulation, we performed a network of confirmatory mediation analyses. RESULTS:We found that SUA has a mediating role inside the bidirectional relationship between IR and visceral obesity, and it is part of an underlying causality mechanism which includes adiponectin. The proportion of the mechanism mediated by SUA is greater when stated that IR (in either peripheral or adipose tissue) leads to VAT accumulation (14.90%[13.20%-17.00%] and 15.54%[13.61% - 18.00%] to 4.88%[3.06%-7.00%] and 8.13%[5.91% - 10.00%]) instead of the opposite direction. This result was confirmed by mediation analyses using gold-standard measurements. CONCLUSIONS:Elevated SUA acts as mediator inside the bidirectional relationship between IR andVAT accumulation. Its role appears to be larger when considering adipose tissue IR as the promoter for VAT accumulation.

scholarly journals Vitamin D Promotes Adiposity But Improves Associated Metabolic Derangements In An Obese Rat Model

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
N A Mohamed ◽  
A A Seif ◽  
M S Abdelhamid ◽  
R S A Eissa
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Adipose Tissue ◽  
Lipid Profile ◽  
Body Mass ◽  
Visceral Adipose Tissue ◽  
Rat Model ◽  
Dose Group ◽  
Tnf Α ◽  
Visceral Adipose

Abstract Background Obesity is a worldwide problem and is a major risk factor for chronic diseases. The relation between obesity and vitamin D is not completely understood. Obesity is associated with vitamin D insufficiency. Some studies claim that vitamin D may reduce lipogenesis and others claim that vitamin D can promote adipogenesis. Aim of the study This study was planned to evaluate the effect of alteration in vitamin D level on body weight and adipose tissue metabolism in an obese rat model. Methods 32 Female Albino-rats were randomly allocated into: control group (C, n = 8), fed on control diet containing 1000 IU vitamin D/kg diet, and a high caloric diet group (HCD, n = 32). The HCD group was further subdivided into 3 groups according to the vitamin D dose into: standard vitamin D dose group (HCD+SVD) containing 1000 IU vitamin D/kg diet, low vitamin D dose group (HCD+LVD) containing 25 IU vitamin D/kg diet and high vitamin D dose group (HCD+HVD) containing 5169 IU vitamin D/kg diet. Body mass index, serum vitamin D, glucose, lipid profile, TNF-α and adipose tissue UCP-1 were measured. Different fat depots were weighed and histopathologically assessed. Results HCD+HVD group showed a significant increase in the final body mass index and in the different fat depot weights compared to all groups. Compared to the HCD+SVD group, the HCD+HVD group showed significantly lower serum total cholesterol and LDL-c levels, while it showed a non-significant change in serum glucose, TNF-α and visceral adipose tissue UCP-1. A significant negative correlation was found between serum 25(OH)D and visceral adipose tissue UCP-1. HCD+LVD showed the highest visceral adipose tissue UCP-1 compared to all groups. Conclusion Vitamin D promoted adiposity and decreased visceral adipose tissue UCP-1 but improved the associated derangements in lipid profile.

scholarly journals Data set for renal sinus fat volume and visceral adipose tissue volume on computed tomography

Data in Brief ◽  
2016 ◽  
Vol 7 ◽  
pp. 1658-1664
Author(s):  
Yoko Murakami ◽  
Yukihiro Nagatani ◽  
Masashi Takahashi ◽  
Mitsuru Ikeda ◽  
Itsuko Miyazawa ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Renal Sinus ◽  
Data Set ◽  
Tissue Volume ◽  
Adipose Tissue Volume ◽  
Visceral Adipose ◽  
Renal Sinus Fat ◽  
Fat Volume

Abdominal Visceral Adipose Tissue Volume Is Associated With Increased Risk of Erosive Esophagitis in Men and Women

2010 ◽  
Vol 139 (6) ◽  
pp. 1902-1911.e2 ◽  
Author(s):  
Su Youn Nam ◽  
Il Ju Choi ◽  
Kum Hei Ryu ◽  
Bum Joon Park ◽  
Hyun Bum Kim ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Erosive Esophagitis ◽  
Men And Women ◽  
Tissue Volume ◽  
Increased Risk ◽  
Adipose Tissue Volume ◽  
Visceral Adipose

scholarly journals Added sugar intake is associated with pericardial adipose tissue volume

2020 ◽  
Vol 27 (18) ◽  
pp. 2016-2023
Author(s):  
So-Yun Yi ◽  
Lyn M Steffen ◽  
James G Terry ◽  
David R Jacobs ◽  
Daniel Duprez ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Sugar Sweetened Beverages ◽  
Added Sugar ◽  
Sugar Sweetened Beverage ◽  
Sweetened Beverage ◽  
Sweetened Beverages ◽  
Pericardial Adipose Tissue ◽  
Adipose Tissue Volume ◽  
Visceral Adipose

Aim The purpose of this study was to determine the relationships of pericardial adipose tissue and visceral adipose tissue volume with added sugar and sugar-sweetened beverage intakes. We hypothesized that both added sugar and sugar-sweetened beverages were positively associated with pericardial adipose tissue and visceral adipose tissue volumes in black and white men and women enrolled in the prospective Coronary Artery Risk Development in Young Adults study. Methods and results Dietary intake was assessed by diet history at baseline, year 7 and year 20 examinations in 3070 participants aged 18-30 and generally healthy at baseline. After 25 years follow-up, participants underwent a computed tomography scan of chest and abdomen; the computed tomography scans were read, and pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes were calculated. Quintiles were created for the average of baseline, year 7 and year 20 added sugar and for the average of sugar-sweetened beverages. General linear regression analysis evaluated the associations of pericardial adipose tissue and visceral adipose tissue volumes across quintiles of added sugar and across quintiles of sugar-sweetened beverage intakes adjusted for potential confounding factors. In a multivariable model, pericardial adipose tissue volume was higher across increasing quintiles of added sugar and sugar-sweetened beverage intakes ( ptrend = 0.001 and ptrend < 0.001, respectively). A similar relation was observed for visceral adipose tissue ( ptrend < 0.001 for both added sugar and sugar-sweetened beverages). Conclusions Long-term intakes of added sugar and sugar-sweetened beverages were associated with higher pericardial adipose tissue, visceral adipose tissue, and subcutaneous adipose tissue volumes. Because these ectopic fat depots are associated with greater risk of disease incidence, these findings support limiting intakes of added sugar and sugar-sweetened beverages.

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