Is SMOF lipid emulsion better than soy-based lipid emulsion for low birth weight preterm neonates?

AbstractThe aim of the study was to determine whether routine probiotic supplementation (RPS) with Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus +Lactobacillus bifidum is associated with reduced risk of necrotising enterocolitis (NEC)≥Stage II in preterm neonates born at ≤32 weeks’ gestation. We conducted a retrospective cohort study on the effect of probiotic supplementation in very low birth weight infants in our neonatal unit by comparing two periods: before and after supplementation. The incidence of NEC≥Stage II, late-onset sepsis and all-cause mortality was compared for an equal period ‘before’ (Period I) and ‘after’ (Period II) RPS with LGG or L. acidophillus+L. bifidum. Multivariate logistic regression analysis was conducted to adjust for relevant confounders. The study population was composed of 261 neonates (Period I v. II: 134 v. 127) with comparable gestation duration and birth weights. In <32 weeks, we observed a significant reduction in NEC≥Stage II (11·3 v. 4·8 %), late-onset sepsis (16 v. 10·5 %) and mortality (19·4 v. 2·3 %). The benefits in neonates aged ≤27 weeks did not reach statistical significance. RPS with LGG or L. acidophillus+L. bifidum is associated with a reduced risk of NEC≥Stage II, late-onset sepsis and mortality in preterm neonates born at ≤32 weeks’ gestation.

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Effects of a fish oil-containing lipid emulsion on serum triglyceride levels and clinical outcomes in extremely low birth weight infants

Clinical Nutrition ◽

10.1016/j.clnu.2018.06.1165 ◽

2018 ◽

Vol 37 ◽

pp. S31-S32

Author(s):

G.M. Park ◽

C.Y. Kim ◽

H.W. Han ◽

J.Y. Kim ◽

E. Jung ◽

...

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Fish Oil ◽

Clinical Outcomes ◽

Lipid Emulsion ◽

Serum Triglyceride ◽

Extremely Low Birth Weight ◽

Low Birth Weight Infants

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Parenteral Soybean Oil Lipid Emulsion in Very Low Birth Weight (VLBW) in Intensive Care

Diet and Nutrition in Critical Care ◽

10.1007/978-1-4614-7836-2_26 ◽

2015 ◽

pp. 1807-1815

Author(s):

Hiromichi Shoji ◽

Toshiaki Shimizu

Keyword(s):

Intensive Care ◽

Birth Weight ◽

Low Birth Weight ◽

Soybean Oil ◽

Lipid Emulsion ◽

Very Low Birth Weight

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Role of Sequential Functional Echocardiography in Predicting Clinically Apparent Patent Ductus Arteriosus in Preterm Very Low Birth Weight Newborns-An Observational Study

10.21203/rs.3.rs-125742/v1 ◽

2020 ◽

Author(s):

Anchala Bhardwaj ◽

ARVIND SAILI ◽

Dinesh Kumar Yadav ◽

Ajay Kumar

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Patent Ductus Arteriosus ◽

Left Atrial ◽

Very Low Birth Weight ◽

Ductus Arteriosus ◽

Preterm Neonates ◽

Predictive Utility ◽

Patent Ductus

Abstract Background The management of patent ductus arteriosus in preterm neonates continues to be a topic of discussion and controversy. Prolonged ductal patency in preterm neonates has been associated with significant short and long term morbidities and with increased mortality however, policy of routine treatment of all during neonatal period has failed to show significant improvement in long term outcome. Echocardiography has emerged as a promising modality to screen the newborns at risk of adverse effects of ductal shunting. This helps in identifying PDAs that require treatment to ultimately prevent unnecessary therapy or delay of necessary therapy. There are multitude of studies that have evaluated large number of echocardiographic markers for their predictive utility but only few have included all ductal markers together in a single study. The reported sensitivity (26-100%) and specificity (6-100%) of echocardiographic markers vary over a wide range. Thus, this study was planned with an aim to assess the predictive utility of all available ductal markers and their added advantage of having all over few ones in clinically apparent PDA in preterm VLBW newborns.Methods It was an observational prospective study conducted in tertiary care NICU at Lady Hardinge Medical College, Delhi. Fifty preterm very low birth weight (VLBW) newborns underwent four sequential Echo scans within first 72 hrs; first scan within 12 hours then at 24 hrs ,48 hrs and 72 hrs of age and were monitored clinically for the signs of PDA up to two weeks of life or discharge whichever comes later.Results The Ductal diameter, pulsatile ductal flow pattern, Left pulmonary artery (LPA) velocity, Left atrial to aortic width (La/Ao) ratio, Left atrial volume index (LAVI), Left ventricle to aortic width (Lv/Ao) ratio, E/A ratio and Left ventricular output/superior vena caval (LVO/SVC) flow ratio predicted clinically apparent PDA during first 72 hours of life.Conclusion This study provides insights into the predictive utility of other ductal echo markers along with the routinely measured conventional ones during first 72 hours of life in preterm VLBW newborns.

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Early Pulmonary Interstitial Emphysema in Preterm Neonates—Respiratory Management and Case Report in Nonventilated Very Low Birth Weight Twins

American Journal of Perinatology Reports ◽

10.1055/s-0038-1648253 ◽

2018 ◽

Vol 08 (02) ◽

pp. e99-e105 ◽

Cited By ~ 2

Author(s):

Judith Gronbach ◽

Harald Ehrhardt ◽

Klaus-Peter Zimmer ◽

Markus Waitz

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Very Low Birth Weight ◽

Respiratory Acidosis ◽

Current Evidence ◽

Preterm Neonates ◽

Management Options ◽

Pulmonary Interstitial Emphysema ◽

Interstitial Emphysema ◽

Respiratory Management

AbstractEarly pulmonary interstitial emphysema in extreme preterm neonates is closely linked with respiratory distress syndrome and exposure to mechanical ventilation. In severe cases, maintaining adequate gas exchange aiming to avoid further lung damage and other neonatal morbidities associated with systemic/pulmonary hypoperfusion, prolonged hypoxia, and respiratory acidosis can be challenging and requires in-depth knowledge into the pathophysiology of the disease. Herein, we report on very low birth weight twins who developed early pulmonary interstitial emphysema during noninvasive respiratory support. We further review the current evidence from the literature, specifically addressing on possible preventive measures and the respiratory management options of this acute pulmonary disease in high-risk neonates.

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DEVELOPMENTAL AND PSYCHOLOGICAL TEST SCORES IN CHILDREN OF LOW BIRTH WEIGHT

PEDIATRICS ◽

10.1542/peds.45.1.9 ◽

1970 ◽

Vol 45 (1) ◽

pp. 9-20

Author(s):

Linda C. Eaves ◽

J. C. Nuttall ◽

H. Klonoff ◽

H. G. Dunn

Keyword(s):

Birth Weight ◽

Low Birth Weight ◽

Test Scores ◽

Scale Up ◽

First Year ◽

Prospective Survey ◽

Developmental Scale ◽

And Performance ◽

Weight Groups ◽

Better Than

In a prospective survey, 420 out of 502 infants of low birth weight (≶ 2,041 gm, or 4½ lb) and all but one of 207 control children of full birth weight (> 2,500 gm, or 5½ lb) have survived for more than 3 years. One hundred fifty of the low birth weight (LBW) group have passed the age of 6 years. Developmental and psychological tests have given the following results: (1) Control children performed better than LBW infants on the Griffiths Developmental Scale up to the age of 18 months; among the LBW infants mean Griffiths Scores in 250 gm birth weight groups mosty differed significantly in direct relation to the weight. (2) LBW girls scored higher than boys after the first year on the hearing-speech subscale and, to a lesser extent, on the personal-social and performance subscales of the Griffiths test and also on the Stanford-Binet and Graham-Ernhart tests at 4 years of age. (3) Whereas the effect of birth weight on I.Q. became less distinct at 2½ to 4 years, the effect of socioeconomic status only became definite at that age. (4) In general, "small-for-dates" (SFD) children, including those born before term, scored higher than "true prematures" up to the age of 12 months and slightly lower at 2½ to 6½ years, but the differences were only significant in a few weight groups. When the SFD children were subdivided into those born at less than 37 weeks' gestation and those born later, the latter scored significantly better than the former only at 3 and 6 months. (5) Isolated Griffiths infant test scores at 6 months per se have little predictive value for I.Q. scores of children at 4 years of age, even at the extremes of intelligence.

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