Genome-wide profiling of microRNAs reveals novel insights into the interactions between H9N2 avian influenza virus and avian dendritic cells

Oncogene ◽  
2018 ◽  
Vol 37 (33) ◽  
pp. 4562-4580 ◽  
Author(s):  
Jian Lin ◽  
Jing Xia ◽  
Tian Zhang ◽  
Keyun Zhang ◽  
Qian Yang
Keyword(s):  
Dendritic Cells ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H9n2 Avian Influenza Virus ◽  
Genome Wide

scholarly journals Analysis of the microRNA expression profiles of chicken dendritic cells in response to H9N2 avian influenza virus infection

2020 ◽  
Vol 51 (1) ◽  
Author(s):  
Jing Yang ◽  
Xinmei Huang ◽  
Yuzhuo Liu ◽  
Dongmin Zhao ◽  
Kaikai Han ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Expression Profiles ◽  
Influenza Virus Infection ◽  
H9n2 Avian Influenza Virus ◽  
Host Interactions ◽  
Deep Sequencing Technology ◽  
Host Defense Response

Abstract MicroRNA (miRNA) plays a key role in virus-host interactions. Here, we employed deep sequencing technology to determine cellular miRNA expression profiles in chicken dendritic cells infected with H9N2 avian influenza virus (AIV). A total of 66 known and 36 novel miRNAs were differently expressed upon H9N2 infection, including 72 up-regulated and 30 down-regulated miRNAs. Functional analysis showed that the predicted targets of these miRNAs were significantly enriched in several pathways including endocytosis, notch, lysosome, p53, RIG-I-like and NOD-like receptor signaling pathways. These data provide valuable information for further investigating the roles of miRNA in AIV pathogenesis and host defense response.

scholarly journals Generation of a recombinant chickenized monoclonal antibody against the neuraminidase of H9N2 avian influenza virus

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Fei Wang ◽  
Yajuan Wang ◽  
Zhimin Wan ◽  
Hongxia Shao ◽  
Kun Qian ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
H9n2 Avian Influenza Virus
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