Optimizing antenatal corticosteroid therapy for improving outcome of premature infants

ABSTARCTIntroductions: One of the most common cause of morbidity and mortality in premature infants is respiratory distress syndrome (RDS). Several studies have shown that a single dose administration of antenatal corticosteroid therapy in women who are at high risk for premature delivery was associated with decreased incidence of RDS. The study aims to determine the effect of antenatal corticosteroid therapy on the incidence of RDS in prematurity in the Department of Child Health Hospital Dr. Soetomo.Methods: Analytic observational case-control design study was used for this research. Samples were taken from the medical records of RDS patients in premature baby and non-RDS with 36 samples in each group.Results: Antenatal corticosteroid therapy has effect in RDS incidence (p = 0.016). While the results of the odds ratio was 0.298 (with 95% CI 0.110 to 0.810), it means that premature infants with antenatal corticosteroid therapy has 0.298 times lower risk than those who were not given antenatal corticosteroid therapy.Conclusion: Antenatal corticosteroid therapy did not provide a direct relathionship to the incidence of respiratory distress syndrome in premature infants, but it a protective factor that can reduce the incidence of RDS in prematurity.

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Antenatal corticosteroid therapy in premature infants

Archives of Gynecology and Obstetrics ◽

10.1007/s00404-004-0664-4 ◽

2004 ◽

Vol 271 (1) ◽

pp. 26-32 ◽

Cited By ~ 11

Author(s):

J. M. Smrcek ◽

N. Schwartau ◽

M. Kohl ◽

C. Berg ◽

A. Geipel ◽

...

Keyword(s):

Corticosteroid Therapy ◽

Premature Infants ◽

Antenatal Corticosteroid

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Faculty Opinions recommendation of Antenatal corticosteroid therapy (ACT) and size at birth: A population-based analysis using the Finnish Medical Birth Register.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.735165401.793572666 ◽

2020 ◽

Author(s):

Katie-Jane Wynne

Keyword(s):

Corticosteroid Therapy ◽

Population Based ◽

Antenatal Corticosteroid ◽

Medical Birth Register ◽

Size At Birth

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Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children

Clinical Science ◽

10.1042/cs0980137 ◽

2000 ◽

Vol 98 (2) ◽

pp. 137-142 ◽

Cited By ~ 106

Author(s):

L. W. DOYLE ◽

G. W. FORD ◽

N. M. DAVIS ◽

C. CALLANAN

Keyword(s):

Blood Pressure ◽

Corticosteroid Therapy ◽

Animal Species ◽

Antenatal Corticosteroid ◽

Antenatal Corticosteroids ◽

Preterm Children ◽

Clinical Hypertension ◽

Blood Pressures ◽

The Relationship ◽

Mercury Sphygmomanometer

Antenatal corticosteroid therapy substantially improves the survival rate of preterm infants, with few side effects. Higher blood pressure in adulthood has been described in several animal species after exposure to antenatal corticosteroids, but there are no similar reports in humans. The objective of the present study was to determine the relationship between exposure to antenatal corticosteroid therapy and blood pressure at 14 years of age. This was a cohort study of 210 preterm survivors with birthweights of < 1501 g born in the Royal Women's Hospital, Melbourne, between 1 January 1977 and 31 March 1982. Blood pressure was measured in 177 subjects (84.3%) at 14 years of age with a standard mercury sphygmomanometer. Children exposed to antenatal corticosteroids (n = 89) had higher systolic and diastolic blood pressures than those not exposed to corticosteroids (n = 88) [mean difference (95% confidence interval) (mmHg): systolic, 4.1 (0.1–8.0); diastolic, 2.8 (0.05–5.6)]. However, few had blood pressure in the hypertensive range. It is concluded that antenatal corticosteroid therapy is associated with higher systolic and diastolic blood pressures in adolescence, and might lead to clinical hypertension in survivors well beyond birth.

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