Impact of antenatal corticosteroid exposure on thymus size in premature infants

ABSTARCTIntroductions: One of the most common cause of morbidity and mortality in premature infants is respiratory distress syndrome (RDS). Several studies have shown that a single dose administration of antenatal corticosteroid therapy in women who are at high risk for premature delivery was associated with decreased incidence of RDS. The study aims to determine the effect of antenatal corticosteroid therapy on the incidence of RDS in prematurity in the Department of Child Health Hospital Dr. Soetomo.Methods: Analytic observational case-control design study was used for this research. Samples were taken from the medical records of RDS patients in premature baby and non-RDS with 36 samples in each group.Results: Antenatal corticosteroid therapy has effect in RDS incidence (p = 0.016). While the results of the odds ratio was 0.298 (with 95% CI 0.110 to 0.810), it means that premature infants with antenatal corticosteroid therapy has 0.298 times lower risk than those who were not given antenatal corticosteroid therapy.Conclusion: Antenatal corticosteroid therapy did not provide a direct relathionship to the incidence of respiratory distress syndrome in premature infants, but it a protective factor that can reduce the incidence of RDS in prematurity.

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Optimizing antenatal corticosteroid therapy for improving outcome of premature infants

Pediatric Research ◽

10.1038/s41390-019-0538-x ◽

2019 ◽

Vol 86 (5) ◽

pp. 556-557 ◽

Cited By ~ 2

Author(s):

Kristi L. Watterberg ◽

Philip L. Ballard

Keyword(s):

Corticosteroid Therapy ◽

Premature Infants ◽

Antenatal Corticosteroid

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The Effects of Antenatal Corticosteroid Treatment on Intraventricular-periventricular hemorrhage (IVH-PVH) of Premature Infants

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2008.2999 ◽

2008 ◽

Vol 8 (1) ◽

pp. 58-63 ◽

Cited By ~ 8

Author(s):

Hajrija Maksić ◽

Feriha Hadžagić-Ćatibušić ◽

Suada Heljić ◽

Jadranka Dizdarević

Keyword(s):

Birth Weight ◽

Premature Infants ◽

Corticosteroid Treatment ◽

Control Group ◽

Antenatal Corticosteroid ◽

Gestation Age ◽

Significant Difference ◽

And Control ◽

Experimental Group ◽

Periventricular Hemorrhage

Intraventricular-periventricular hemorrhage (IVH-PVH) is the most frequent type of intracranial hemorrhage in premature infants and the major cause of neurodevelopmental disabilities in children too.The objective of this work is to evaluate the effects of prenatal corticosteroid treatment on the incidence of IVH-PVH in premature infants.The study enrolled 163 prematures of 26-34 weeks’ gestation. They have been divided into two groups: the experimental group (80/163), who have been treated with corticosteroids prenatally and control group (83/163), who have not received such treatment.There is statistically significant difference in IVH-PVH incidence between the experimental group (18/80) and control group (32/83) (χ2 =5,616, p<0,05).There is no statistically significant difference in Apgar score after 5 minutes between the experimental group and control group of IVH-PVH prematures, t= 0,121.There is no statistically significant difference in mean gestation age between the experimental group (30,74 weeks) and control group (29,97 weeks) of IVH-PVH prematures, t= 1,299.There is no statistically significant difference in mean birth weight between the experimental group (1479,44 grams) and control group (1379,37 grams) of IVH-PVH prematures, t= 0,913.Antenatal corticosteroid treatment of premature infants reduced the incidence of IVH-PVH significantly. There is no statistically significant difference in Apgar score after 5 minutes, mean gestation age and mean birth weight between the experimental and control group of IVH PVH prematures.

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