Neddylation of sterol regulatory element-binding protein 1c is a potential therapeutic target for nonalcoholic fatty liver treatment

Cell Death and Disease ◽

10.1038/s41419-020-2472-6 ◽

2020 ◽

Vol 11 (4) ◽

Author(s):

Uk-Il Ju ◽

Do-Won Jeong ◽

Jieun Seo ◽

Jun Bum Park ◽

Jong-Wan Park ◽

...

Keyword(s):

Fatty Liver ◽

Therapeutic Target ◽

Binding Protein ◽

Regulatory Element ◽

Potential Therapeutic Target ◽

Nonalcoholic Fatty Liver ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Preventing Phosphorylation of Sterol Regulatory Element-Binding Protein 1a by MAP-Kinases Protects Mice from Fatty Liver and Visceral Obesity

PLoS ONE ◽

10.1371/journal.pone.0032609 ◽

2012 ◽

Vol 7 (2) ◽

pp. e32609 ◽

Author(s):

Jorg Kotzka ◽

Birgit Knebel ◽

Jutta Haas ◽

Lorena Kremer ◽

Sylvia Jacob ◽

...

Keyword(s):

Fatty Liver ◽

Map Kinases ◽

Binding Protein ◽

Regulatory Element ◽

Visceral Obesity ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Xanthohumol Improves Diet-induced Obesity and Fatty Liver by Suppressing Sterol Regulatory Element-binding Protein (SREBP) Activation

Journal of Biological Chemistry ◽

10.1074/jbc.m115.656975 ◽

2015 ◽

Vol 290 (33) ◽

pp. 20565-20579 ◽

Author(s):

Shingo Miyata ◽

Jun Inoue ◽

Makoto Shimizu ◽

Ryuichiro Sato

Keyword(s):

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Diet Induced Obesity ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element–Binding Protein-1c

Journal of Pharmacological Sciences ◽

10.1254/jphs.08182fp ◽

2009 ◽

Vol 109 (4) ◽

pp. 486-495 ◽

Author(s):

Hu-Quan Yin ◽

Young-Tae Je ◽

Young-Chul Kim ◽

Young-Kee Shin ◽

SangHyun Sung ◽

...

Keyword(s):

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Alcoholic Fatty Liver ◽

Element Binding Protein ◽

Sterol Regulatory Element ◽

Magnolia Officinalis

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Estrogen-related receptor γ controls sterol regulatory element-binding protein-1c expression and alcoholic fatty liver

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids ◽

10.1016/j.bbalip.2019.158521 ◽

2019 ◽

Vol 1864 (12) ◽

pp. 158521

Author(s):

Don-Kyu Kim ◽

Yong-Hoon Kim ◽

Jae-Ho Lee ◽

Yoon Seok Jung ◽

Jina Kim ◽

...

Keyword(s):

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Alcoholic Fatty Liver ◽

Element Binding Protein ◽

Sterol Regulatory Element ◽

Estrogen Related Receptor

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Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis

European Journal of Pharmacology ◽

10.1016/j.ejphar.2012.06.021 ◽

2012 ◽

Vol 691 (1-3) ◽

pp. 9-18 ◽

Author(s):

Sang Dal Rhee ◽

Chi-Hyun Kim ◽

Ji Seon Park ◽

Won Hoon Jung ◽

Sung Bum Park ◽

...

Keyword(s):

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Amelioration of free fatty acid‐induced fatty liver by quercetin‐3‐O‐β‐D‐glucuronide through modulation of peroxisome proliferator‐activated receptor‐alpha/sterol regulatory element‐binding protein‐1c signaling

Hepatology Research ◽

10.1111/hepr.12557 ◽

2015 ◽

Vol 46 (2) ◽

pp. 225-238 ◽

Author(s):

Lu Lu Wang ◽

Zhi Chao Zhang ◽

Waseem Hassan ◽

Yu Li ◽

Jun Liu ◽

...

Keyword(s):

Free Fatty Acid ◽

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Receptor Alpha ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Overexpression of Sterol Regulatory Element-binding Protein-1a in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty Liver

Journal of Biological Chemistry ◽

10.1074/jbc.m306540200 ◽

2003 ◽

Vol 278 (38) ◽

pp. 36652-36660 ◽

Author(s):

Jay D. Horton ◽

Iichiro Shimomura ◽

Shinji Ikemoto ◽

Yuriy Bashmakov ◽

Robert E. Hammer

Keyword(s):

Adipose Tissue ◽

Fatty Liver ◽

Acid Secretion ◽

Binding Protein ◽

Regulatory Element ◽

Element Binding Protein ◽

Sterol Regulatory Element ◽

Adipocyte Hypertrophy

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Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression

European Journal of Pharmacology ◽

10.1016/j.ejphar.2011.05.014 ◽

2011 ◽

Vol 666 (1-3) ◽

pp. 183-188 ◽

Author(s):

Rao Du ◽

Jie Xue ◽

Heng-bin Wang ◽

Yan Zhang ◽

Mei-lin Xie

Keyword(s):

Gene Expression ◽

Fatty Liver ◽

Target Gene ◽

Binding Protein ◽

Regulatory Element ◽

Target Gene Expression ◽

Element Binding Protein ◽

Sterol Regulatory Element

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Modulation of hepatic sterol regulatory element-binding protein-1c-mediated gene expression contributes to Salacia oblonga root-elicited improvement of fructose-induced fatty liver in rats

Journal of Ethnopharmacology ◽

10.1016/j.jep.2013.10.020 ◽

2013 ◽

Vol 150 (3) ◽

pp. 1045-1052 ◽

Author(s):

Lei Liu ◽

Ming Yang ◽

Xuemei Lin ◽

Ying Li ◽

Changjin Liu ◽

...

Keyword(s):

Gene Expression ◽

Fatty Liver ◽

Binding Protein ◽

Regulatory Element ◽

Element Binding Protein ◽

Sterol Regulatory Element ◽

Salacia Oblonga

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25-Hydroxycholesterol-3-Sulfate Decreases Hepatic Steatosis and Inflammation in Mouse Models of Nonalcoholic Fatty Liver Disease by Down-Regulating Sterol Regulatory Element Binding Protein-1c

Gastroenterology ◽

10.1016/s0016-5085(11)64071-7 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-982

Author(s):

Leyuan Xu ◽

Qianming Bai ◽

Genta Kakiyama ◽

Douglas M. Heuman ◽

William M. Pandak ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Nonalcoholic Fatty Liver Disease ◽

Hepatic Steatosis ◽

Mouse Models ◽

Fatty Liver Disease ◽

Regulatory Element ◽

Nonalcoholic Fatty Liver ◽

Element Binding Protein ◽

Sterol Regulatory Element

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