scholarly journals Dynamic regulation of DNA nanostructures by noncanonical nucleic acids

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Shiliang He ◽  
Zhilei Ge ◽  
Xiaolei Zuo ◽  
Chunhai Fan ◽  
Xiuhai Mao
Keyword(s):  
Nucleic Acids ◽  
Spatial Organization ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Structural Morphology ◽  
Dynamic Regulation ◽  
Hierarchical Assembly ◽  
Dna Triplexes ◽  
Potential Applications ◽  
External Stimuli

AbstractDNA nanostructures are among the most fascinating self-assembled nanostructures in diverse areas of science and technology, because of their nanoscale precision in biomolecule and nanoparticle organization. The implementation of dynamic and spatial regulation in structural morphology and hierarchical assembly upon specific external stimuli will greatly expand their applications in biocomputation, clinical diagnosis, and cancer therapy. Recently, noncanonical nucleic acids, particularly DNA triplexes, i-motifs, and G-quadruplexes, have become powerful tools for biosensing and mechanical switching. Developments in incorporating stimuli-responsive noncanonical nucleic acids into DNA nanostructures provide a promising approach to regulating the spatial organization and hierarchical assembly of DNA nanostructures. In this review, we briefly introduce recent progress in constructing DNA nanostructures with dynamic regulation of the structural transformation and programmable assembly pathways at the nanometer scale by noncanonical nucleic acids and discuss their potential applications and challenges.

scholarly journals Dynamic Manipulation of THz Waves Enabled by Phase-Transition VO2 Thin Film

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 114
Author(s):  
Chang Lu ◽  
Qingjian Lu ◽  
Min Gao ◽  
Yuan Lin
Keyword(s):  
Optical Methods ◽  
Stimuli Responsive ◽  
Device Structure ◽  
Current State ◽  
Insulator Metal Transition ◽  
Potential Applications ◽  
Fs Laser ◽  
External Stimuli ◽  
Thz Applications ◽  
Thz Waves

The reversible and multi-stimuli responsive insulator-metal transition of VO2, which enables dynamic modulation over the terahertz (THz) regime, has attracted plenty of attention for its potential applications in versatile active THz devices. Moreover, the investigation into the growth mechanism of VO2 films has led to improved film processing, more capable modulation and enhanced device compatibility into diverse THz applications. THz devices with VO2 as the key components exhibit remarkable response to external stimuli, which is not only applicable in THz modulators but also in rewritable optical memories by virtue of the intrinsic hysteresis behaviour of VO2. Depending on the predesigned device structure, the insulator-metal transition (IMT) of VO2 component can be controlled through thermal, electrical or optical methods. Recent research has paid special attention to the ultrafast modulation phenomenon observed in the photoinduced IMT, enabled by an intense femtosecond laser (fs laser) which supports “quasi-simultaneous” IMT within 1 ps. This progress report reviews the current state of the field, focusing on the material nature that gives rise to the modulation-allowed IMT for THz applications. An overview is presented of numerous IMT stimuli approaches with special emphasis on the underlying physical mechanisms. Subsequently, active manipulation of THz waves through pure VO2 film and VO2 hybrid metamaterials is surveyed, highlighting that VO2 can provide active modulation for a wide variety of applications. Finally, the common characteristics and future development directions of VO2-based tuneable THz devices are discussed.

Probing the spatial organization of nucleic acids within cells by nonisotopic in situ hybridization

1992 ◽  
Vol 50 (1) ◽  
pp. 10-11
Author(s):  
Jeanne Bentley Lawrence
Keyword(s):  
In Situ Hybridization ◽  
Nucleic Acids ◽  
Spatial Organization ◽  
Experimental Approach ◽  
Single Cells ◽  
Potential Applications ◽  
A Cell ◽  
Differential Gene ◽  
High Degree

In situ hybridization is a powerful experimental approach that directly couples molecular and cytological information in a visual context. Advances in hybridization procedures over recent years, coupled with previously described non-isotopic labelling methods developed in a number of laboratories, now provide a way to detect nucleic acids within cells with a high degree of resolution and sensitivity. Adaptations of this technology allow either DNA or RNA to be detected and visualized either with the light microscope, using fluorescence or colorimetric methods, or with the electron microscope using antibodies conjugated to gold or peroxidase. The potential applications of this technology are relevant to numerous areas of biomedical research and range from the more straightforward study of differential gene expression in single cells within a population to the precise localization of individual genes or RNAs within the cytoplasm or nucleus of a cell.

Control of the stepwise assembly–disassembly of DNA origami nanoclusters by pH stimuli-responsive DNA triplexes

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18026-18030 ◽  
Author(s):  
Shuo Yang ◽  
Wenyan Liu ◽  
Risheng Wang
Keyword(s):  
Self Assembly ◽  
Dna Origami ◽  
Dna Nanostructures ◽  
Stimuli Responsive ◽  
Dna Triplexes ◽  
Stepwise Assembly

We demonstrate the pH-regulated, multistep self-assembly of DNA nanostructures by employing DNA triplexes as dynamic linkers in a stepwise, selective, and reversible fashion.

Development of External Stimuli-Responsive Nucleic Acids by Sugar, Backbone, and Nucleobase Modification

Synlett ◽  
2014 ◽  
Vol 25 (11) ◽  
pp. 1499-1510 ◽  
Author(s):  
Satoshi Obika ◽  
Kunihiko Morihiro ◽  
Tetsuya Kodama
Keyword(s):  
Nucleic Acids ◽  
Stimuli Responsive ◽  
External Stimuli

scholarly journals Helical Actuators Inspired by Chiral Seedpod Opening and Tendril Coiling

2018 ◽  
Author(s):  
Guangchao Wan ◽  
Congran Jin ◽  
Ian Trase ◽  
Shan Zhao ◽  
Zi Chen
Keyword(s):  
Multiwall Carbon Nanotubes ◽  
Artificial Muscles ◽  
Stimuli Responsive ◽  
Helical Structures ◽  
Responsive Materials ◽  
Intelligent Machines ◽  
Essential Components ◽  
Potential Applications ◽  
External Stimuli ◽  
Tendril Coiling

Actuators are essential components for intelligent machines that can fulfill certain tasks in response to environmental stimuli. In recent years, actuators that can transform from a 2D ribbon shape to a 3D helical configuration under certain external stimuli have attracted significant attention due to the potential applications of the targeted helical structures in springs, propulsion generation, and artificial muscles. Inspired by the chiral opening of Bauhinia variegate‘s seedpods and the coiling of the Towel Gourd tendril with perversions, researchers have made significant breakthroughs in synthesizing state-of-the-art actuators capable of mimicking helical transformations. In this review, we give a brief overview of the shape evolution mechanisms of these two plant structures and then review recent progress in the fabrication of biomimetic helical actuators. These structures are categorized by the stimuli-responsive materials involved, including hydrogels, liquid crystal networks/elastomers, shape memory polymers, and multiwall carbon nanotubes. By providing this survey on important recent advances along with our perspectives, we hope to solicit new inspirations and insights on the development and fabrication of smart actuators, as well as the future development of interdisciplinary research at the interface of physics, engineering, and biology.

scholarly journals Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer

2019 ◽  
Author(s):  
Colin Swenson ◽  
Arventh Velusamy ◽  
Hector Argueta-Gonzalez ◽  
Jennifer Heemstra
Keyword(s):  
Amino Acid ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Sequence Recognition ◽  
Potential Applications ◽  
Assembly Behavior ◽  
Aqueous Conditions

<div> <div> <div> <p>Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex structures and perform wide-ranging activities. Although Nature has evolved machinery to read the nucleic acid code and translate it into amino acid code, the extant biopolymers are restricted to encoding amino acid or nucleotide sequences separately, limiting their potential applications in medicine and biotechnology. Here we describe the design, synthesis, and stimuli-responsive assembly behavior of a bilingual biopolymer that integrates both amino acid and nucleobase sequences into a single peptide nucleic acid (PNA) scaffold to enable tunable storage and retrieval of tertiary structural behavior and programmable molecular recognition capabilities. Incorporation of a defined sequence of amino acid side-chains along the PNA backbone yields amphiphiles having a “protein code” that directs self-assembly into micellar architectures in aqueous conditions. However, these amphiphiles also carry a “nucleotide code” such that subsequent introduction of a complementary RNA strand induces a sequence-specific disruption of assemblies through hybridization. Together, these properties establish bilingual PNA as a powerful biopolymer that combines two information systems to harness structural responsiveness and sequence recognition. The PNA scaffold and our synthetic system are highly generalizable, enabling fabrication of a wide array of user-defined peptide and nucleotide sequence combinations for diverse future biomedical and nanotechnology applications. </p> </div> </div> </div>

scholarly journals Bilingual Peptide Nucleic Acids: Encoding the Languages of Nucleic Acids and Proteins in a Single Self-Assembling Biopolymer

2019 ◽  
Author(s):  
Colin Swenson ◽  
Arventh Velusamy ◽  
Hector Argueta-Gonzalez ◽  
Jennifer Heemstra
Keyword(s):  
Amino Acid ◽  
Nucleic Acid ◽  
Nucleic Acids ◽  
Self Assembly ◽  
Stimuli Responsive ◽  
Design Synthesis ◽  
Sequence Recognition ◽  
Potential Applications ◽  
Assembly Behavior ◽  
Aqueous Conditions

<div> <div> <div> <p>Nucleic acids and proteins are the fundamental biopolymers that support all life on Earth. Nucleic acids store large amounts of information in nucleobase sequences while peptides and proteins utilize diverse amino acid functional groups to adopt complex structures and perform wide-ranging activities. Although Nature has evolved machinery to read the nucleic acid code and translate it into amino acid code, the extant biopolymers are restricted to encoding amino acid or nucleotide sequences separately, limiting their potential applications in medicine and biotechnology. Here we describe the design, synthesis, and stimuli-responsive assembly behavior of a bilingual biopolymer that integrates both amino acid and nucleobase sequences into a single peptide nucleic acid (PNA) scaffold to enable tunable storage and retrieval of tertiary structural behavior and programmable molecular recognition capabilities. Incorporation of a defined sequence of amino acid side-chains along the PNA backbone yields amphiphiles having a “protein code” that directs self-assembly into micellar architectures in aqueous conditions. However, these amphiphiles also carry a “nucleotide code” such that subsequent introduction of a complementary RNA strand induces a sequence-specific disruption of assemblies through hybridization. Together, these properties establish bilingual PNA as a powerful biopolymer that combines two information systems to harness structural responsiveness and sequence recognition. The PNA scaffold and our synthetic system are highly generalizable, enabling fabrication of a wide array of user-defined peptide and nucleotide sequence combinations for diverse future biomedical and nanotechnology applications. </p> </div> </div> </div>

Smart Polymers and their Applications: A Review

2017 ◽  
Vol 8 (03) ◽  
Author(s):  
Gore S. A. ◽  
Gholve S. B. ◽  
Savalsure S. M. ◽  
Ghodake K. B. ◽  
Bhusnure O. G. ◽  
...  
Keyword(s):  
Oil Recovery ◽  
Water Soluble ◽  
Solution Temperature ◽  
Smart Polymers ◽  
Stimuli Responsive ◽  
Responsive Materials ◽  
Water Soluble Polymers ◽  
Commercial Applications ◽  
Stimuli Sensitive ◽  
External Stimuli

Smart polymers are materials that respond to small external stimuli. These are also referred as stimuli responsive materials or intelligent materials. Smart polymers that can exhibit stimuli-sensitive properties are becoming important in many commercial applications. These polymers can change shape, strength and pore size based on external factors such as temperature, pH and stress. The stimuli include salt, UV irradiation, temperature, pH, magnetic or electric field, ionic factors etc. Smart polymers are very promising applicants in drug delivery, tissue engineering, cell culture, gene carriers, textile engineering, oil recovery, radioactive wastage and protein purification. The study is focused on the entire features of smart polymers and their most recent and relevant applications. Water soluble polymers with tunable lower critical solution temperature (LCST) are of increasing interest for biological applications such as cell patterning, smart drug release, DNA sequencing etc.

scholarly journals Metal-Organic Framework-Based Stimuli-Responsive Polymers

2021 ◽  
Vol 5 (4) ◽  
pp. 101
Author(s):  
Menglian Wei ◽  
Yu Wan ◽  
Xueji Zhang
Keyword(s):  
Metal Organic Framework ◽  
Chemical Properties ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Reversible Phase Transition ◽  
Metal Organic ◽  
External Stimuli ◽  
Organic Framework

Metal-organic framework (MOF) based stimuli-responsive polymers (coordination polymers) exhibit reversible phase-transition behavior and demonstrate attractive properties that are capable of altering physical and/or chemical properties upon exposure to external stimuli, including pH, temperature, ions, etc., in a dynamic fashion. Thus, their conformational change can be imitated by the adsorption/desorption of target analytes (guest molecules), temperature or pressure changes, and electromagnetic field manipulation. MOF-based stimuli responsive polymers have received great attention due to their advanced optical properties and variety of applications. Herein, we summarized some recent progress on MOF-based stimuli-responsive polymers (SRPs) classified by physical and chemical responsiveness, including temperature, pressure, electricity, pH, metal ions, gases, alcohol and multi-targets.

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