Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

Top-down attention is a dynamic cognitive process that facilitates the detection of the task-relevant stimuli from our complex sensory environment. A neural mechanism capable of deployment under specific task-demand conditions would be crucial to efficiently control attentional processes and improve promote goal-directed attention performance during fluctuating attentional demand. Previous studies have shown that frontal top-down neurons projecting from the anterior cingulate area (ACA) to the visual cortex (VIS; ACAVIS) are required for visual attentional behavior during the 5-choice serial reaction time task (5CSRTT) in mice. However, it is unknown whether the contribution of these projecting neurons is dependent on the extent of task demand. Here, we first examined how behavior outcomes depend on the number of locations for mice to pay attention and touch for successful performance, and found that the 2-choice serial reaction time task (2CSRTT) is less task demanding than the 5CSRTT. We then employed optogenetics to demonstrate that suppression ACAVIS projections immediately before stimulus presentation has no effect during the 2CSRTT in contrast to the impaired performance during the 5CSRTT. These results suggest that ACAVIS projections are necessary when task demand is high, but once a task demand is lowered, ACAVIS neuron activity becomes dispensable to adjust attentional performance. These findings support a model that the frontal-sensory ACAVIS projection regulates visual attention behavior during specific high task demand conditions, pointing to a flexible circuit-based mechanism for promoting attentional behavior.

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Nicotinic regulation of local and long-range input balance drives top-down attentional circuit maturation

Science Advances ◽

10.1126/sciadv.abe1527 ◽

2021 ◽

Vol 7 (10) ◽

pp. eabe1527

Author(s):

Elisa N. Falk ◽

Kevin J. Norman ◽

Yury Garkun ◽

Michael P. Demars ◽

Susanna Im ◽

...

Keyword(s):

Long Range ◽

Cognitive Deficits ◽

Neurodevelopmental Disorders ◽

Cholinergic System ◽

Fragile X ◽

Top Down ◽

Dynamic Regulation ◽

Key Driver ◽

Maturational Process ◽

Attentional Behavior

Cognitive function depends on frontal cortex development; however, the mechanisms driving this process are poorly understood. Here, we identify that dynamic regulation of the nicotinic cholinergic system is a key driver of attentional circuit maturation associated with top-down frontal neurons projecting to visual cortex. The top-down neurons receive robust cholinergic inputs, but their nicotinic tone decreases following adolescence by increasing expression of a nicotinic brake, Lynx1. Lynx1 shifts a balance between local and long-range inputs onto top-down frontal neurons following adolescence and promotes the establishment of attentional behavior in adulthood. This key maturational process is disrupted in a mouse model of fragile X syndrome but was rescued by a suppression of nicotinic tone through the introduction of Lynx1 in top-down projections. Nicotinic signaling may serve as a target to rebalance local/long-range balance and treat cognitive deficits in neurodevelopmental disorders.

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Task Demand-dependent Contribution of Frontal-Sensory Cortical Projections to Attentional Behavior in Mice

10.1101/2021.04.08.439093 ◽

2021 ◽

Author(s):

Kevin J Norman ◽

Julia Bateh ◽

Priscilla Maccario ◽

Christina Cho ◽

Keaven Caro ◽

...

Keyword(s):

Reaction Time ◽

Visual Attention ◽

Reaction Time Task ◽

Serial Reaction Time Task ◽

Task Demand ◽

Neuron Activity ◽

Serial Reaction Time ◽

Top Down ◽

Serial Reaction ◽

Attentional Behavior

Top-down attention is a dynamic cognitive process that facilitates the detection of the task-relevant stimuli from our complex sensory environment. A neural mechanism capable of deployment under specific task-demand conditions would be crucial to efficiently control attentional processes and improve goal-directed attention performance in task demand-dependent manner. Previous studies have shown that frontal top-down neurons projecting from anterior cingulate area (ACA) to the visual cortex (VIS; ACAvis) are required for attentional behavior during the 5-choice serial reaction time task (5CSRTT) in mice. However, it is unknown whether the contribution of this projecting neurons is dependent on the extent of task demand. Here, we examine the differential contribution of ACAvis projection neurons to the attentional behavior in adult male mice performing two visual attention tasks of varying task demand: the 5CSRTT and 2-choice serial reaction time task (2CSRTT). We found that optogenetic suppression ACAvis projections immediately before stimulus presentation has no effect during the 2CSRTT in contrast to the impaired performance during the 5CSRTT. Fiber photometry calcium imaging of ACAvis neuron activity revealed that these neurons, which are recruited after errors during 5CSRTT, are not recruited during 2CSRTT. These results suggest that ACAvis projections are necessary only when task demand is high and that ACAvis neuron activity may not provide an error monitoring signal when task demand is low. Collectively, this frontal-sensory ACAvis projection regulates visual attention behavior during specific high task demand conditions, pointing to a flexible circuit-based mechanism for promoting attentional behavior.

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Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice

10.1101/2020.05.26.117929 ◽

2020 ◽

Author(s):

Elisa M Nabel ◽

Yury Garkun ◽

Hiroyuki Koike ◽

Masato Sadahiro ◽

Ana Liang ◽

...

Keyword(s):

Long Range ◽

Attentional Control ◽

Cortical Neurons ◽

Anterior Cingulate ◽

Sensitive Period ◽

Neuron Activity ◽

Top Down ◽

Local Circuitry ◽

Local Circuits ◽

Attentional Behavior

AbstractFrontal top-down cortical neurons projecting to sensory cortical regions are well-positioned to integrate long-range inputs with local circuitry in frontal cortex to implement top-down attentional control of sensory regions. How adolescence contributes to the maturation of top-down neurons and associated local/long-range input balance, and the establishment of attentional control is poorly understood. Here we combine projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood. Chemogenetic suppression of top-down neuron activity selectively during adolescence, but not later periods, produces long-lasting visual attentional behavior deficits, and results in excessive loss of local excitatory inputs in adulthood. Our study reveals an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior.

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Top-Down Processing and Visual Reorientation Illusions in a Virtual Reality Environment

Swiss Journal of Psychology ◽

10.1024/1421-0185.63.3.143 ◽

2004 ◽

Vol 63 (3) ◽

pp. 143-149 ◽

Cited By ~ 3

Author(s):

Fred W. Mast ◽

Charles M. Oman

Keyword(s):

Virtual Reality ◽

Visual Processing ◽

Line Length ◽

Perceptual Cues ◽

Virtual Reality Environment ◽

Top Down ◽

Test Conditions ◽

The Subject ◽

Processing Mechanisms

The role of top-down processing on the horizontal-vertical line length illusion was examined by means of an ambiguous room with dual visual verticals. In one of the test conditions, the subjects were cued to one of the two verticals and were instructed to cognitively reassign the apparent vertical to the cued orientation. When they have mentally adjusted their perception, two lines in a plus sign configuration appeared and the subjects had to evaluate which line was longer. The results showed that the line length appeared longer when it was aligned with the direction of the vertical currently perceived by the subject. This study provides a demonstration that top-down processing influences lower level visual processing mechanisms. In another test condition, the subjects had all perceptual cues available and the influence was even stronger.

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Functional Anatomy of Intensity Aspects of Attention

Zeitschrift für Neuropsychologie ◽

10.1024/1016-264x.14.3.181 ◽

2003 ◽

Vol 14 (3) ◽

pp. 181-190 ◽

Cited By ~ 2

Author(s):

Walter Sturm

Keyword(s):

Right Hemisphere ◽

Functional Anatomy ◽

Fmri Data ◽

Functional Networks ◽

Top Down ◽

Stimulus Modality ◽

Spatial Orienting ◽

Phasic Alertness ◽

Co Activation ◽

Attention System

Abstract: Behavioral and PET/fMRI-data are presented to delineate the functional networks subserving alertness, sustained attention, and vigilance as different aspects of attention intensity. The data suggest that a mostly right-hemisphere frontal, parietal, thalamic, and brainstem network plays an important role in the regulation of attention intensity, irrespective of stimulus modality. Under conditions of phasic alertness there is less right frontal activation reflecting a diminished need for top-down regulation with phasic extrinsic stimulation. Furthermore, a high overlap between the functional networks for alerting and spatial orienting of attention is demonstrated. These findings support the hypothesis of a co-activation of the posterior attention system involved in spatial orienting by the anterior alerting network. Possible implications of these findings for the therapy of neglect are proposed.

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Auswirkungen eines Aufmerksamkeitstrainings auf die aphasische Symptomatik bei Schlaganfallpatienten

Zeitschrift für Neuropsychologie ◽

10.1024/1016-264x/a000027 ◽

2011 ◽

Vol 22 (1) ◽

pp. 21-32 ◽

Cited By ~ 2

Author(s):

Julia Graf ◽

Hartwig Kulke ◽

Christa Sous-Kulke ◽

Wilfried Schupp ◽

Stefan Lautenbacher

Keyword(s):

Top Down

Aufmerksamkeit kann als Kontrollsystem neuronaler Aktivität verstanden werden, welches Neuroplastizität top-down modulieren hilft. Bisher wurde selten versucht, durch deren gezielte Förderung Funktionswiederherstellungen nach Hirnschädigung zu begünstigen. In vorliegender Studie wurde dies am Beispiel der Aphasie erprobt. 15 Schlaganfallpatienten erhielten ein dreiwöchiges Training der selektiven Aufmerksamkeit mit den PC-Programmen CogniPlus und „Konzentration“ bei fünf Sitzungen pro Woche zusätzlich zur Standardtherapie, 13 weitere bildeten eine Kontrollgruppe ohne Aufmerksamkeitstraining. Zur Effektivitätskontrolle dienten zwei Versionen des Untertests Go/Nogo (Testbatterie zur Aufmerksamkeitsprüfung) und die Kurze Aphasieprüfung. Nach dem Training manifestierte sich zwischen den Untersuchungsgruppen kein Unterschied in Aufmerksamkeits- und Sprachfunktionen; das zusätzliche Aufmerksamkeitstraining war also wirkungslos. Allerdings zeigten Patienten mit deutlichen Aufmerksamkeitsverbesserungen tendenziell weniger Aphasie-Symptome, was die Hypothese aufmerksamkeitsvermittelter Plastizitätsmodulation nach Hirnschädigung partiell stützt.

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Aufmerksamkeitswechsel und Konzentration: Von den Funktionen zum Mechanismus

Zeitschrift für Psychologie / Journal of Psychology ◽

10.1026//0044-3409.209.1.34 ◽

2001 ◽

Vol 209 (1) ◽

pp. 34-53 ◽

Cited By ~ 1

Author(s):

Rainer Bösel

Keyword(s):

Top Down ◽

Eeg Alpha

Zusammenfassung. Aufmerksamkeit wird sowohl als Selektivität in der bewußter Verarbeitung oder auch als selektive neuronale Aktivierung verstanden. Die neuronalen Strukturen, die Objektdiskrimination ermöglichen, erlauben eine Interaktion von datengetriebenen und endogenen top-down Prozessen, die zu einer selektiven Bereitstellung von Verarbeitungs-Ressourcen führen. Zielgerichtetes Verhalten erfordert manchmal einen Wechsel in der Ressourcen-Bereitstellung und eine Konzentration von mentaler Aktivität. Aufmerksamkeitswechsel kann als ein zweiphasiger Prozeß verstanden werden, der aus einer breiten Mobilisierung von Gedächtnis-Ressourcen besteht (angezeigt durch EEG-Theta), gefolgt von einer re-organisierenden Einengung neuronaler Aktivität (angezeigt durch langsames EEG-Alpha). Dieser Beitrag unterstützt die Annahme, daß die Analyse des gekoppelten Wechselspiels aus Mobilisierung und Konzentration in bestimmten Teilen der posterioren und anterioren Rindenregionen ein Schlüssel für das Verständnis von Aufmerksamkeitswechsel sein könnte.

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