scholarly journals Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Haohao Wu ◽  
Charles Petitpré ◽  
Paula Fontanet ◽  
Anil Sharma ◽  
Carmelo Bellardita ◽  
...  
Keyword(s):  
Sensory Feedback ◽  
Sensory Input ◽  
Motor Behavior ◽  
Dorsal Root Ganglion Neurons ◽  
Adult Mice ◽  
Motor Network ◽  
Complex Motor ◽  
Innervation Patterns ◽  
Ganglion Neurons ◽  
Proprioceptive Function

AbstractProprioceptive neurons (PNs) are essential for the proper execution of all our movements by providing muscle sensory feedback to the central motor network. Here, using deep single cell RNAseq of adult PNs coupled with virus and genetic tracings, we molecularly identify three main types of PNs (Ia, Ib and II) and find that they segregate into eight distinct subgroups. Our data unveil a highly sophisticated organization of PNs into discrete sensory input channels with distinct spatial distribution, innervation patterns and molecular profiles. Altogether, these features contribute to finely regulate proprioception during complex motor behavior. Moreover, while Ib- and II-PN subtypes are specified around birth, Ia-PN subtypes diversify later in life along with increased motor activity. We also show Ia-PNs plasticity following exercise training, suggesting Ia-PNs are important players in adaptive proprioceptive function in adult mice.

scholarly journals Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function

Neuron ◽  
2016 ◽  
Vol 91 (3) ◽  
pp. 708-710 ◽  
Author(s):  
Gyu-Sang Hong ◽  
Byeongjun Lee ◽  
Jungwon Wee ◽  
Hyeyeon Chun ◽  
Hyungsup Kim ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons ◽  
Proprioceptive Function

scholarly journals PDK1 is a negative regulator of axon regeneration

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Hyemin Kim ◽  
Jinyoung Lee ◽  
Yongcheol Cho
Keyword(s):  
Nervous System ◽  
Axon Regeneration ◽  
Dorsal Root Ganglion Neurons ◽  
Negative Regulator ◽  
Protein Levels ◽  
Adult Mice ◽  
The Central Nervous System ◽  
Ganglion Neurons

AbstractAxon regeneration in the central nervous system is inefficient. However, the neurons in the peripheral nervous system display robust regeneration after injury, indicating that axonal regeneration is differentially controlled under various conditions. To identify those molecules regulating axon regeneration, comparative analysis from dorsal root ganglion neurons at embryonic or adult stages is utilized, which reveals that PDK1 is functions as a negative regulator of axon regeneration. PDK1 is downregulated in embryonic neurons after axotomy. In contrast, sciatic nerve axotomy upregulated PDK1 at protein levels from adult mice. The knockdown of PDK1 or the chemical inhibition of PDK1 promotes axon regeneration in vitro and in vivo. Here we present PDK1 as a new player to negatively regulate axon regeneration and as a potential target in the development of therapeutic applications.

scholarly journals Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function

Neuron ◽  
2016 ◽  
Vol 91 (1) ◽  
pp. 107-118 ◽  
Author(s):  
Gyu-Sang Hong ◽  
Byeongjun Lee ◽  
Jungwon Wee ◽  
Hyeyeon Chun ◽  
Hyungsup Kim ◽  
...  
Keyword(s):  
Dorsal Root Ganglion ◽  
Dorsal Root ◽  
Dorsal Root Ganglion Neurons ◽  
Ganglion Neurons ◽  
Proprioceptive Function

Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression

2020 ◽  
Vol 18 (10) ◽  
pp. 791-797
Author(s):  
Qiong Xiang ◽  
Jing-Jing Li ◽  
Chun-Yan Li ◽  
Rong-Bo Tian ◽  
Xian-Hui Li
Keyword(s):  
Sciatic Nerve ◽  
Dorsal Root Ganglion ◽  
Nerve Injury ◽  
Dorsal Root ◽  
Underlying Mechanism ◽  
Dorsal Root Ganglion Neurons ◽  
Mechanical Hyperalgesia ◽  
Bax Protein ◽  
Ganglion Neurons

Background: Our previous study has indicated that somatostatin potently inhibits neuropathic pain through the activation of its type 2 receptor (SSTR2) in mouse dorsal root ganglion and spinal cord. However, the underlying mechanism of this activation has not been elucidated clearly Objective: The aim of this study is to perform the pharmacological studies on the basis of sciatic nerve-pinch mice model and explore the underlying mechanism involving SSTR2. Methods: On the basis of a sciatic nerve-pinch injury model, we aimed at comparing the painful behavior and dorsal root ganglion neurons neurochemical changes after the SSTR2 antibody (anti- SSTR2;5μl,1μg/ml) administration in the mouse. Results: After pinch nerve injury, we found that the mechanical hyperalgesia and severely painful behavior (autotomy) were detected after the application of SSTR2 antibody (anti-SSTR2; 5μl, 1μg/ml) on the pinch-injured nerve. The up-regulated phosphorylated ERK (p-ERK) expression and the apoptotic marker (i.e., Bax) were significantly decreased in DRGs after anti-SSTR2 treatment. Conclusion: The current data suggested that inhibitory changes in proteins from the apoptotic pathway in anti-SSTR2-treated groups might be taking place to overcome the protein deficits caused by SSTR2 antibody and supported the new therapeutic intervention with SSTR2 antagonist for neuronal degeneration following nerve injury.

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