Haematopoietic cell transplantation outcomes are linked to intestinal mycobiota dynamics and an expansion of Candida parapsilosis complex species

2021 ◽  
Author(s):  
Thierry Rolling ◽  
Bing Zhai ◽  
Mergim Gjonbalaj ◽  
Nicholas Tosini ◽  
Keiko Yasuma-Mitobe ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Candida Parapsilosis ◽  
Complex Species ◽  
Haematopoietic Cell ◽  
Candida Parapsilosis Complex ◽  
Transplantation Outcomes

scholarly journals Comparison of four molecular approaches to identify Candida parapsilosis complex species

2017 ◽  
Vol 112 (3) ◽  
pp. 214-219 ◽  
Author(s):  
Leonardo Silva Barbedo ◽  
Maria Helena Galdino Figueiredo-Carvalho ◽  
Mauro de Medeiros Muniz ◽  
Rosely Maria Zancopé-Oliveira
Keyword(s):  
Candida Parapsilosis ◽  
Complex Species ◽  
Molecular Approaches ◽  
Candida Parapsilosis Complex

Virulence properties and sensitivity profile of Candida parapsilosis complex species and Kodamaea ohmeri isolates from onychomycosis of HIV/AIDS patients

2019 ◽  
Vol 132 ◽  
pp. 282-292 ◽  
Author(s):  
Erika Oliveira Ferreira ◽  
Iven Neylla Vale Farias Mendes ◽  
Sílvio Gomes Monteiro ◽  
Karla Tonelli Bicalho Crosara ◽  
Walter Luiz Siqueira ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Aids Patients ◽  
Complex Species ◽  
Kodamaea Ohmeri ◽  
Candida Parapsilosis Complex ◽  
Virulence Properties ◽  
Sensitivity Profile ◽  
Hiv Aids

scholarly journals Intestinal fungal dynamics and linkage to hematopoietic cell transplantation outcomes.

2021 ◽  
Author(s):  
Thierry Rolling ◽  
Bing Zhai ◽  
Mergim Gjonbalaj ◽  
Nicholas Tosini ◽  
Keiko Yasuma-Mitobe ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Amplicon Sequencing ◽  
Hematopoietic Cell ◽  
Complex Species ◽  
Bacterial Microbiota ◽  
16S Amplicon Sequencing ◽  
Transplantation Outcomes ◽  
Related Mortality

Allogeneic hematopoietic cell transplantation (allo-HCT) induces profound shifts in the intestinal bacterial microbiota. The dynamics of intestinal fungi and their impact on clinical outcomes have not yet been integrated into a model of microbiota function during allo-HCT. Here, we combined parallel high-throughput fungal ITS1 amplicon sequencing, bacterial 16S amplicon sequencing, and fungal cultures to reveal striking trans-kingdom dynamics and their association with patient outcomes. We saw that the overall density and the biodiversity of intestinal fungi were stable during allo-HCT, but the species composition changed drastically from day to day. We identified a subset of patients with fungal dysbiosis characterized by culture positivity, stable expansion of Candida parapsilosis complex species, and distinct trans-kingdom microbiota profiles. These patients had worse overall survival and higher transplant-related mortality independent of candidemia. Our data expand the clinical significance of the mycobiota and suggest that targeting fungal dysbiosis may help to improve long-term patient survival.

scholarly journals Molecular identification and antifungal susceptibility profiles of Candida parapsilosis complex species isolated from culture collection of clinical samples

2015 ◽  
Vol 48 (4) ◽  
pp. 454-459 ◽  
Author(s):  
Fábio Silvestre Ataides ◽  
Carolina Rodrigues Costa ◽  
Lúcia Kioko Hasimoto e Souza ◽  
Orionalda deFátima Lisboa Fernandes ◽  
Rosália Santos Amorim Jesuino ◽  
...  
Keyword(s):  
Molecular Identification ◽  
Candida Parapsilosis ◽  
Antifungal Susceptibility ◽  
Culture Collection ◽  
Clinical Samples ◽  
Complex Species ◽  
Candida Parapsilosis Complex ◽  
Susceptibility Profiles

scholarly journals Identification and Differentiation of Candida parapsilosis Complex Species by Use of Exon-Primed Intron-Crossing PCR

2014 ◽  
Vol 52 (5) ◽  
pp. 1758-1761 ◽  
Author(s):  
X. Feng ◽  
Z. Wu ◽  
B. Ling ◽  
S. Pan ◽  
W. Liao ◽  
...  
Keyword(s):  
Candida Parapsilosis ◽  
Complex Species ◽  
Candida Parapsilosis Complex
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