A new GLP1, GIP and glucagon receptor triagonist

2022 ◽  
Author(s):  
Shimona Starling
Keyword(s):  
Glucagon Receptor

An Allosteric Glucagon Receptor Antagonist, LGD-6972, Displays Biased Receptor Signaling

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1117-P ◽  
Author(s):  
ERIC G. VAJDA ◽  
LIN ZHI ◽  
KEITH MARSCHKE
Keyword(s):  
Receptor Antagonist ◽  
Receptor Signaling ◽  
Glucagon Receptor ◽  
Glucagon Receptor Antagonist

Cholesterol 7 Alpha–Hydroxylase (CYP7A1) Activity and 7–Alpha–Hydroxy–4–Cholesten–3–One (C4) Are Not Translatable Biomarkers of Glucagon Receptor (GCGR) Activation

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1113-P
Author(s):  
RAUL CAMACHO ◽  
WENYU LI ◽  
THOMAS KIRCHNER ◽  
RUI ZHANG ◽  
FANY BONILLA ◽  
...  
Keyword(s):  
Glucagon Receptor

MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, Shows Differential Brain Activation vs. Liraglutide in Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1789-P
Author(s):  
LUKE K. BURKE ◽  
LEE BROWN ◽  
JEAN-MARTIN LAPOINTE ◽  
MICHAL GRZEGORZ SULIKOWSKI ◽  
ARTHUR R. LEWIS ◽  
...  
Keyword(s):  
Brain Activation ◽  
Glucagon Receptor ◽  
Dual Agonist

Evaluating the Sub-chronic Effects of MEDI0382, a GLP-1/Glucagon Receptor Dual Agonist, on Weight Loss in Male ob/ob Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1890-P
Author(s):  
STEPHANIE OLDHAM ◽  
CHRISTOPHER D. CHURCH ◽  
SARAH WILL ◽  
ANISH KONKAR ◽  
JAMES TREVASKIS ◽  
...  
Keyword(s):  
Weight Loss ◽  
Glucagon Receptor ◽  
Chronic Effects ◽  
Dual Agonist

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1010-P
Author(s):  
VICTORIA E. PARKER ◽  
DARREN ROBERTSON ◽  
TAO WANG ◽  
DAVID C. HORNIGOLD ◽  
MAXIMILIAN G. POSCH ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Receptor Activity ◽  
Glucagon Receptor

1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1870-P
Author(s):  
SHELLY NASON ◽  
TEAYOUN KIM ◽  
JESSICA P. ANTIPENKO ◽  
BRIAN FINAN ◽  
RICHARD DIMARCHI ◽  
...  
Keyword(s):  
Hepatic Steatosis ◽  
Leptin Receptor ◽  
Receptor Expression ◽  
Receptor Signaling ◽  
Glucagon Receptor

1813-P: Coadministration of a GLP-1/Glucagon Receptor Agonist with an FXR Agonist and ACC Inhibitor Reverses Nonalcoholic Steatohepatitis (NASH) in Diet-Induced and Biopsy-Confirmed Mice

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1813-P
Author(s):  
JAMES L. TREVASKIS ◽  
JENNY NORLIN ◽  
DIEGO A. MIRANDA ◽  
JAMIE G. BATES ◽  
NORA E. ZOIS ◽  
...  
Keyword(s):  
Nonalcoholic Steatohepatitis ◽  
Receptor Agonist ◽  
Glucagon Receptor

1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1965-P
Author(s):  
TEAYOUN KIM ◽  
JESSICA P. ANTIPENKO ◽  
SHELLY NASON ◽  
NATALIE PRESEDO ◽  
WILLIAM J. VAN DER POL ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Antibiotic Treatment ◽  
Body Weight Loss ◽  
Obese Mice ◽  
Glucagon Receptor
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