scholarly journals Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

2022 ◽  
Author(s):  
Chansavath Phetsouphanh ◽  
David R. Darley ◽  
Daniel B. Wilson ◽  
Annett Howe ◽  
C. Mee Ling Munier ◽  
...  
Keyword(s):  
Immunological Dysfunction

scholarly journals Colorectal Carcinoma Affected Patients Are Significantly Poor Responders Against the Oncogenic JC Polyomavirus

2021 ◽  
Vol 12 ◽  
Author(s):  
Elena Torreggiani ◽  
Ilaria Bononi ◽  
Silvia Pietrobon ◽  
Elisa Mazzoni ◽  
Giovanni Guerra ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Synthetic Peptides ◽  
Enzyme Linked Immunosorbent Assay ◽  
Poor Responders ◽  
Igg Antibodies ◽  
Healthy Individuals ◽  
Jc Polyomavirus ◽  
Oncogenic Potential ◽  
Different Types ◽  
Immunological Dysfunction

BackgroundMany investigations reported the association between human tumors and JCPyV, a polyomavirus with oncogenic potential. The association has been supported by studies that found JCPyV footprints in CRC and gliomas of different types. Indeed, JCPyV footprints including its nucleic acids and Tag oncoprotein have been revealed in CRC tissues.MethodsHerein, sera from colorectal carcinoma (CRC) affected patients and healthy individuals (HS), employed as control, were analysed for immunoglobulin G (IgG) antibodies against specific JCPyV viral capsid protein 1 (VP1) antigens. The investigation was carried out employing an innovative immunological assay. Indeed, an indirect enzyme-linked immunosorbent assay (ELISA) with JCPyV VP1 mimotopes was used. JCPyV VP1 mimotopes consisted of synthetic peptides mimicking VP1 epitopes.ResultsSera from CRC affected patients, evaluated using indirect ELISAs with synthetic mimotopes, showed a significant lower prevalence of IgG antibodies against JCPyV VP1 mimotopes (26%) compared to HS (51%), p<0.005. These data were confirmed by another method, the hemagglutination inhibition (HAI) assay. Altogether these results, i.e. the prevalence of serum IgG antibodies against JCPyV VP1 mimotopes from patients with CRC is approximately 50% lower than in HS, are of interest.DiscussionOur data suggest that patients with CRC are significantly poor responders against JCPyV VP1 antigens. It is possible that CRC patients are affected by a specific immunological deregulation. This immunological dysfunction, revelled in CRC patients, may account for their predisposition to the colorectal carcinoma onset.

scholarly journals IL-17, IL-27, and IL-33: A Novel Axis Linked to Immunological Dysfunction During Sepsis

2019 ◽  
Vol 10 ◽  
Author(s):  
Kristen N. Morrow ◽  
Craig M. Coopersmith ◽  
Mandy L. Ford
Keyword(s):  
Immunological Dysfunction

Current Perspectives on Immunology and Psychiatry

1988 ◽  
Vol 22 (4) ◽  
pp. 366-382 ◽  
Author(s):  
Maryanne O'donnell ◽  
Derrick Silove ◽  
Denis Wakefield
Keyword(s):  
Psychological Distress ◽  
Clinical Significance ◽  
Mental Illnesses ◽  
Complex Relationship ◽  
Affective States ◽  
Research Attention ◽  
Dopamine Hypothesis ◽  
Research Findings ◽  
Immunological Dysfunction ◽  
Methodological Difficulties

We selectively review recent research findings in the field of psychoimmunology which test the hypotheses that immunological dysfunction may be aetiologically related to mental illnesses such as schizophrenia, and that certain morbid affective states such as depression and other forms of psychosocial distress may be the cause of immunosuppression and through this mechanism affect the outcome of illnesses such as cancer. Our examination of research implicating immunological or infective mechanisms in the aetiology of schizophrenia indicates that most studies have been unable to control for major methodological difficulties but the compatibility of these theories with the dopamine hypothesis suggests that further research attention is warranted. More clearly, there is growing evidence demonstrating a link between depression, other states of psychological distress and immunosuppression, but the clinical significance of these findings remains uncertain. The complex relationship between stress and the outcome of illnesses such as cancer is discussed and the possible implications of these findings for clinical psychiatry are suggested.

Immunological and Psychological Dysfunction in Patients Receiving Immunotherapy for Chronic Fatigue Syndrome

1992 ◽  
Vol 26 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Ian Hickie ◽  
Andrew Lloyd ◽  
Denis Wakefield
Keyword(s):  
Depressive Symptoms ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Response To Treatment ◽  
Active Immunotherapy ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Fatigue Syndrome ◽  
Psychological Dysfunction ◽  
Immunological Dysfunction

Associations between immunological and psychological dysfunction in 33 patients with Chronic Fatigue Syndrome (CFS) were examined before and in response to treatment in a double blind, placebo-controlled trial of high dose intravenous immunoglobulin. Only those patients who received active immunotherapy demonstrated a consistent pattern of correlations between improvement in depressive symptoms and markers of cell-mediated immunity (CMI). This finding lends some support to the hypothesis that depressive symptoms in patients with CFS occur secondary to, or share a common pathophysiology with, immunological dysfunction. This pattern and the lack of strong associations between depression and immunological disturbance prior to treatment are less supportive of the view that CFS is primarily a form of depressive disorder or that immunological dysfunction in patients with CFS is secondary to concurrent depression.

Murine Acariasis. II. Immunological Dysfunction and Evidence for Chronic Activation of Th‐2 Lymphocytes

1996 ◽  
Vol 43 (6) ◽  
pp. 604-612 ◽  
Author(s):  
P. JUNGMANN ◽  
A. FREITAS ◽  
A. BANDEIRA ◽  
A. NOBREGA ◽  
A. COUTINHO ◽  
...  
Keyword(s):  
Chronic Activation ◽  
Immunological Dysfunction

scholarly journals Clinical Features and Lymphocyte Subsets in Recovered Covid-19 Patients With Prolonged Viral Rna Shedding Duration

2020 ◽  
Author(s):  
Wei-yun Zhang ◽  
Kai Wu ◽  
Ying-ying Liu ◽  
Chang-guo Wang ◽  
Jian-an Huang ◽  
...  
Keyword(s):  
T Cells ◽  
B Cells ◽  
Nk Cells ◽  
Clinical Features ◽  
Poor Prognosis ◽  
Lymphocyte Subsets ◽  
Viral Rna ◽  
Viral Shedding ◽  
Novel Coronavirus ◽  
Immunological Dysfunction

Abstract Background:The 2019 novel coronavirus disease (COVID-19) spread in many countries.Data about viral shedding duration, particularly the prolonged ones of the pathogen SARS-Coronavirus-2 (SARS-CoV-2) is scarce. The longest viral RNA sheddingduration reported previously was 37 days. Herein, we report the clinical and immunologic features ofrecovered COVID-19cases with a medium viral RNA shedding duration of 44 days. Cases presentation: Nine laboratory-confirmed COVID-19 cases from Wuhan with viral RNA shedding duration more than 30 days were included in our study,5 of them were moderate.Althoughinflammatory markers were significantlyhigher, the medium duration in severepatients was similar to that in moderate patients (44.5days vs. 43.6days). Severepatients showed higher NK cells levels, although the T cells and B cells were lower as compared with moderate patients. Contrary to previous reports in influenza, prolonged viralshedding time did not cause poor prognosis in this study.Conclusions: There could be characteristic immunological dysfunction in COVID-19 patients with prolonged viral shedding durationand interestingly, prolonged viral shedding duration seemed not to be related with poor prognosis.

Sign in / Sign up

Export Citation Format

Share Document