The relationship between red cell distribution width and all-cause and cause-specific mortality in a general population

Abstract Red Cell Distribution Width (RDW) could be a risk factor for developing various chronic diseases, and seems to be a prognostic marker in patients with cardiovascular disease (CVD) or cancer. Our aim was to explore the association between RDW and all-cause and cause-specific mortality in a general population. RDW was measured in 27,063 participants (aged 45–73 years) from the population-based Malmö Diet and Cancer cohort. After a follow-up of 19.8 ± 5.5 years, Cox proportional hazards regression analysis was used to study the relationship between RDW and all-cause and cause-specific mortality, with adjustment for confounding factors. A total of 9388 individuals (4715 men and 4673 women) died during the follow up. High RDW was significantly associated with all-cause mortality (HR, 4th vs. 1st quartile: 1.34, 95%CI: 1.24–1.45), cancer mortality (HR: 1.27, 95%CI: 1.12–1.44), CVD mortality (HR: 1.39, 95%CI: 1.21–1.59), and respiratory disease mortality (HR: 1.47, 95%CI: 1.06–2.03). The C-statistic increased significantly from 0.732 to 0.737 when adding RDW to a model adjusted for age and sex. There was a significant interaction between RDW and BMI with respect to all-cause mortality. We concluded that RDW is associated with mortality and propose that high RDW is a significant, but non-specific marker of mortality risk in the general population.

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Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population

Thrombosis and Haemostasis ◽

10.1160/th14-04-0335 ◽

2015 ◽

Vol 113 (01) ◽

pp. 193-200 ◽

Cited By ~ 16

Author(s):

Jostein Lappegård ◽

Tove Skjelbakken ◽

Sigrid Brækkan ◽

John-Bjarne Hansen ◽

Trygve S. Ellingsen

Keyword(s):

Venous Thromboembolism ◽

General Population ◽

Case Fatality ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality ◽

Recurrent Vte

SummaryRecent studies suggest an association between red cell distribution width (RDW) and incident venous thromboembolism (VTE). We aimed to investigate the impact of RDW on risk of incident and recurrent VTE, and case-fatality, in a general population. RDW was measured in 26,223 participants enrolled in the Tromsø Study in 1994–1995. Incident and recurrent VTE events and deaths during follow-up were registered until January 1, 2012. Multivariate Cox proportional hazards regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI). There were 647 incident VTE events during a median of 16.8 years of follow-up. Individuals with RDW in the highest quartile (RDW≥13.3%) had 50% higher risk of an incident VTE than those in the lowest quartile (RDW≤12.3%). The association was strongest for unprovoked deep-vein thrombosis (HR highest vs lowest quartile of RDW: 1.8, 95% CI 1.1–3.1). VTE patients with baseline RDW≥13.3% had 30% higher risk of all-cause mortality after the initial VTE event than VTE patients with RDW<13.3%. There were no association between RDW and risk of recurrent VTE. Our findings suggest that high RDW is a risk factor of incident VTE, and that RDW is a predictor of all-cause mortality in VTE patients.

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Red cell distribution width is associated with future risk of incident stroke

Thrombosis and Haemostasis ◽

10.1160/th15-03-0234 ◽

2016 ◽

Vol 115 (01) ◽

pp. 126-134 ◽

Cited By ~ 25

Author(s):

Trygve S. Ellingsen ◽

Tove Skjelbakken ◽

Ellisiv B. Mathiesen ◽

Inger Njølstad ◽

Tom Wilsgaard ◽

...

Keyword(s):

General Population ◽

Blood Cell ◽

Cell Count ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Blood Cell Count ◽

Distribution Width ◽

Risk Of Death

SummaryRed cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth survey of the Tromsø Study, conducted in 1994/95. Incident stroke was registered from inclusion until December 31, 2010. Cox regression models were used to calculate hazard ratios (HR) with 95 % confidence intervals (95 % CI) for stroke, adjusted for age, sex, body mass index, smoking, haemoglobin level, white blood cell count, thrombocyte count, hypertension, total cholesterol, triglycerides, self-reported diabetes, and red blood cell count. During a median follow-up of 15.8 years, 1152 participants experienced a first-ever stroke. A 1 % increment in RDW yielded a 13 % higher risk of stroke (multivariable HR: 1.13, 95 % CI: 1.07–1.20). Subjects with RDW in the highest quintile compared to the lowest had a 37 % higher risk of stroke in multivariable analysis (HR: 1.37, 95 % CI: 1.11–1.69). Subjects with RDW above the 95-percentile had 55 % higher risk of stroke compared to those in the lowest quintile (HR: 1.55, 95 % CI: 1.16–2.06). All risk estimates remained unchanged after exclusion of subjects with anaemia (n=1102). RDW was not associated with increased risk of death within one year or during the entire follow-up after an incident stroke. RDW is associated with incident stroke in a general population, independent of anaemia and traditional atherosclerotic risk factors.

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