Red cell distribution width, illness severity, and all‐cause mortality in dogs admitted to the ICU

Background and Methods. Red cell distribution width (RDW) has emerged as a prognostic marker in patients with cardiovascular diseases. We investigated mortality in patients with diabetes included in the National Health and Nutrition Examination Survey, in relation to baseline RDW. RDW was divided into 4 quartiles (Q1: ≤12.4%, Q2: 12.5%–12.9%, Q3: 13.0%–13.7%, and Q4: >13.7%). Results. A total of 3,061 patients were included: mean age 61±14 years, 50% male, 39% White. Mean RDW was 13.2%±1.4%. Compared with first quartile (Q1) of RDW, patients in Q4 were more likely to be older, female, and African-American, have had history of stroke, myocardial infarction, and heart failure, and have chronic kidney disease. After a median follow-up of 6 years, 628 patient died (29% of cardiovascular disease). Compared with Q1, patients in Q4 were at increased risk for all-cause mortality (HR 3.44 [2.74–4.32], P<.001) and cardiovascular mortality (HR 3.34 [2.16–5.17], P<.001). After adjusting for 17 covariates, RDW in Q4 remained significantly associated with all-cause mortality (HR 2.39 [1.30–4.38], P=0.005) and cardiovascular mortality (HR 1.99 [1.17–3.37], P=0.011). Conclusion. RDW is a powerful and an independent marker for prediction of all-cause mortality and cardiovascular mortality in patients with diabetes.

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Abstract 090: Outcomes of Hypertensive Crises as Predicted by Red Cell Distribution Width

Hypertension ◽

10.1161/hyp.66.suppl_1.090 ◽

2015 ◽

Vol 66 (suppl_1) ◽

Author(s):

Suraj Raheja ◽

Kush Patel ◽

Ruchir Patel ◽

Sagger Mawri ◽

Alexander Michaels ◽

...

Keyword(s):

Heart Failure ◽

Independent Predictor ◽

Hypertensive Crisis ◽

Red Cell Distribution Width ◽

Categorical Variables ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality ◽

New Onset

Background: Red cell distribution width (RDW) is a measure of the variability in size of erythrocytes. A high RDW value indicates greater variation in size between individual erythrocytes and has been shown to be an independent predictor of mortality in patients with coronary artery disease, heart failure and in patients undergoing percutaneous coronary intervention (PCI). The aim of this study was to evaluate the prognostic value of RDW in predicting clinical outcomes in patients with hypertensive crisis. Methods: We performed a retrospective study of 465 consecutive patients from January 2007 to March 2010 who presented with hypertensive crisis. Hypertensive crisis was defined as systolic BP >180 and/or diastolic BP >110mmHg with impending or progressive end organ dysfunction requiring inpatient hospitalization. The study sample consisted of 465 patients (38.9% men (181 of 465); mean age 59.6 ± 15.9). Baseline levels of RDW were measured at time of admission and analyzed as continuous and categorical variables (elevated RDW was defined as >14.5%). Multivariable regression analysis was performed for development of all-cause mortality, myocardial infarction, new-onset heart failure (defined as first time hospital admission for heart failure), stroke and MACE (MI, new-onset heart failure and stroke) at 2 years. Results: RDW > 14.5% was a strong independent predictor of all-cause mortality at 2 years (OR: 1.90, 95% CI: 1.1-3.3, p <0.05). Elevated RDW was also found to be an independent predictor of new-onset heart failure at 2 years (OR: 1.97, 95% CI: 1.1-3.7, p <0.05). Elevated RDW was not a predictor of MI, PCI or stroke at 2 years. Conclusions: Elevated RDW level in patients with hypertensive crisis was an independent predictor of all-cause mortality and new-onset heart failure in patients with hypertensive crisis.

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Red cell distribution width is associated with incident venous thromboembolism (VTE) and case-fatality after VTE in a general population

Thrombosis and Haemostasis ◽

10.1160/th14-04-0335 ◽

2015 ◽

Vol 113 (01) ◽

pp. 193-200 ◽

Cited By ~ 16

Author(s):

Jostein Lappegård ◽

Tove Skjelbakken ◽

Sigrid Brækkan ◽

John-Bjarne Hansen ◽

Trygve S. Ellingsen

Keyword(s):

Venous Thromboembolism ◽

General Population ◽

Case Fatality ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality ◽

Recurrent Vte

SummaryRecent studies suggest an association between red cell distribution width (RDW) and incident venous thromboembolism (VTE). We aimed to investigate the impact of RDW on risk of incident and recurrent VTE, and case-fatality, in a general population. RDW was measured in 26,223 participants enrolled in the Tromsø Study in 1994–1995. Incident and recurrent VTE events and deaths during follow-up were registered until January 1, 2012. Multivariate Cox proportional hazards regression models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI). There were 647 incident VTE events during a median of 16.8 years of follow-up. Individuals with RDW in the highest quartile (RDW≥13.3%) had 50% higher risk of an incident VTE than those in the lowest quartile (RDW≤12.3%). The association was strongest for unprovoked deep-vein thrombosis (HR highest vs lowest quartile of RDW: 1.8, 95% CI 1.1–3.1). VTE patients with baseline RDW≥13.3% had 30% higher risk of all-cause mortality after the initial VTE event than VTE patients with RDW<13.3%. There were no association between RDW and risk of recurrent VTE. Our findings suggest that high RDW is a risk factor of incident VTE, and that RDW is a predictor of all-cause mortality in VTE patients.

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Red Cell Distribution Width: A Predictor of All-Cause Mortality in Patients with Coronary Artery Disease

Cardiology ◽

10.1159/000368393 ◽

2014 ◽

Vol 130 (1) ◽

pp. 23-24

Author(s):

Sevket Balta ◽

Mustafa Aparci ◽

Cengiz Ozturk ◽

Sait Demirkol ◽

Turgay Celik

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality ◽

Artery Disease

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Red Cell Distribution Width and Mortality in Patients Undergoing Percutaneous Coronary Intervention

Biomedicines ◽

10.3390/biomedicines10010045 ◽

2021 ◽

Vol 10 (1) ◽

pp. 45

Author(s):

Min-Tsun Liao ◽

Chao-Lun Lai ◽

Ting-Chuan Wang ◽

Jou-Wei Lin ◽

Yi-Lwun Ho ◽

...

Keyword(s):

Percutaneous Coronary Intervention ◽

Health Insurance ◽

Cox Regression ◽

Coronary Intervention ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Percutaneous Coronary ◽

All Cause Mortality

Red cell distribution width (RDW) can effectively predict prognosis in coronary artery disease (CAD) patients following percutaneous coronary intervention (PCI). There is currently no relevant research to demonstrate a linear or non-linear association between RDW and mortality. This is a multi-center, retrospective cohort study, with data collected from 2006 to 2017. Source data included electronic medical records of the Integrated Medical Database of National Taiwan University Hospital, and health insurance claims from the National Health Insurance Administration. Patients were stratified into five groups according to RDW values (13.4%, 14.1%, 14.8%, and 15.9%). Multivariable logistic and Cox regression analyses were used to determine 1-year all-cause and cardiovascular (CV) mortalities. Data of 10,669 patients were analyzed and those with the lowest RDW (≤13.3%) served as the reference group. The adjusted odds ratios (ORs) of 1-year all-cause mortality from the second to fifth RDW group were 1.386, 1.589, 2.090, and 3.192, respectively (p for trend < 0.001). The adjusted ORs of 1-year CV mortality were 1.555, 1.585, 1.623, and 2.850, respectively (p for trend = 0.015). The adjusted hazard ratios (HRs) of 1-year all-cause mortality were 1.394, 1.592, 2.003, and 2.689, respectively (p for trend = 0.006). The adjusted HRs of 1-year CV mortality were 1.533, 1.568, 1.609, and 2.710, respectively (p for trend = 0.015). RDW was an independent predicting factor and had a linear relationship with the 1-year all-cause and CV mortalities in patients undergoing PCI. Thus, RDW may be a clinically useful parameter to predict the mortality in those patients.

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Pulmonary-Specific Intermountain Risk Score Predicts All-Cause Mortality via Spirometry, the Red Cell Distribution Width, and Other Laboratory Parameters

Respiratory Care ◽

10.4187/respcare.03370 ◽

2015 ◽

Vol 60 (9) ◽

pp. 1314-1323 ◽

Cited By ~ 8

Author(s):

B. D. Horne ◽

M. Hegewald ◽

J. B. Muhlestein ◽

H. T. May ◽

E. J. Huggins ◽

...

Keyword(s):

Risk Score ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

Laboratory Parameters ◽

All Cause Mortality

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Association Between Red Cell Distribution Width and Cardiovascular Outcomes – Systematic Review and Meta-Analysis

Medical Research Archives ◽

10.18103/mra.v9i7.2468 ◽

2021 ◽

Vol 9 (7) ◽

Author(s):

Sagar Ranka ◽

Shubham Lahan ◽

Tarun Dalia ◽

Alok Tripathi ◽

Amandeep Goyal ◽

...

Keyword(s):

Heart Failure ◽

Systematic Review ◽

Congestive Heart Failure ◽

Meta Analysis ◽

Red Cell Distribution Width ◽

Red Cell ◽

Cell Distribution ◽

Distribution Width ◽

All Cause Mortality ◽

St Elevation

Objective: Increased red cell distribution width (RDW) has been associated with poor prognosis in patients with heart failure (HF) and coronary heart disease (CHD) in multiple observation studies. We conducted this meta-analysis to determine composite impact of RDW on cardiovascular outcomes in patients with HF and CHD. Methodology: Literature search of databases such as PubMed/Medline, Google Scholar, and Cochrane library was conducted from inception till 16 th August, 2020 to identify all the relevant studies reporting all-cause mortality based on the RDW levels in patients with HF and CHD (ST- elevation & non-ST elevation myocardial infarction, coronary artery disease). The data was extracted from retrieved results for performing this systematic review and meta-analysis. Results: A total of 32 studies were included with a total of 58, 518 patients. The ages ranged from 49-80 years with males being 47%–98% in proportion. We observed that the pooled estimate of hazard ratio (HR) for all-cause mortality among patients with congestive heart failure (CHF) was 1.16 (95% CI 1.10–1.23; p <0.001), and the pooled HR for all-cause mortality among CHD patients was 1.19 (95% CI 1.09–1.29; p = 0.001) in patients with elevated RDW levels. Conclusion: Elevated RDW levels either at the time of admission, during the course of stay in hospital, or at the time of discharge significantly correlate with the increased all-cause mortality among CHF and CHD patients. Elevated RDW can have prognostic importance in anticipating the risk of death in these subset of patients. Keywords: Red cell distribution width; congestive heart failure; coronary artery/heart disease; all-cause mortality.

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