scholarly journals Machine Learning (ML) based-method applied in recurrent pregnancy loss (RPL) patients diagnostic work-up: a potential innovation in common clinical practice

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
V. Bruno ◽  
M. D’Orazio ◽  
C. Ticconi ◽  
P. Abundo ◽  
S. Riccio ◽  
...  
Keyword(s):  
Machine Learning ◽  
Clinical Practice ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Common Clinical Practice ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

scholarly journals Recurrent Pregnancy Loss: A Tragic Reproductive Failure

1970 ◽  
Vol 2 (2) ◽  
pp. 29-35
Author(s):  
Mst Rashida Begum ◽  
Mariya Ehsan ◽  
Mst Sahina Begum ◽  
Hosne Ara Baby ◽  
Maruf Siddiqui ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Genetic Diagnosis ◽  
Life Style Changes ◽  
Consecutive Pregnancy ◽  
Genetic Problem ◽  
Immunological Factors ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Three or more consecutive pregnancy losses are considered as recurrent pregnancy loss (RPL). About 1% of all pregnant women face this distressing problem and o.5% to 5% of spontaneous abortions are recurrent. Genetic, environmental, anatomic, hormonal, infectious and immunological factors are associated with RPL. Sometimes several factors might simultaneously be responsible for RPL. So diagnostic work up is to be extended. Life style changes, hormonal supplementation, anticoagulant and immunotherapy and surgical correction of certain uterine anatomic defects might help the couple to be parent. Genetic problem can be overcome by pre-implantation genetic diagnosis (PGD) and transferring good healthy embryos. Key Words: Recurrent Pregnancy Loss (RPL); Pre Implantation Genetic Diagnosis (PGD) DOI: http://dx.doi.org/10.3329/akmmcj.v2i2.8170 AKMMC J 2011; 2(2): 29-35

Problem solving in clinical practice: the sick infant with low sodium and high potassium

2020 ◽  
pp. edpract-2019-317756
Author(s):  
Yincent Tse ◽  
Nidhi Singhal ◽  
Leigh McDonald ◽  
Milan Gopal ◽  
Anupam Lall ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Problem Solving ◽  
High Potassium ◽  
Initial Management ◽  
Low Sodium ◽  
Life Threatening ◽  
Diagnostic Work ◽  
Work Up ◽  
Term Management ◽  
Diagnostic Work Up

Many paediatricians will be faced with a sick infant who on investigation is found to have hyponatraemia and hyperkalaemia at some time in their career. The focus of initial management includes the treatment of potentially life-threatening hyperkalaemia with concurrent investigation aiming to elucidate whether the underlying cause reflects a primarily renal or endocrine pathology. We describe the presentation of two infants who each presented with one of the more common underlying diagnoses that led to this biochemical disturbance and discuss the approach to immediate treatment, diagnostic work-up and longer term management.

scholarly journals Diagnostic Work-up and Follow-up in Children with Tall Stature: A Simplified Algorithm for Clinical Practice

2015 ◽  
Vol 7 (4) ◽  
pp. 260-267 ◽  
Author(s):  
Susanne E. Stalman ◽  
Anke Pons ◽  
Jan M. Wit ◽  
Gerdine A. Kamp ◽  
Frans B. Plötz
Keyword(s):  
Clinical Practice ◽  
Tall Stature ◽  
Simplified Algorithm ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

scholarly journals Diagnosis and Treatment of Idiopathic Premature Ventricular Contractions: A Stepwise Approach Based on the Site of Origin

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1840
Author(s):  
Daniele Muser ◽  
Massimo Tritto ◽  
Marco Valerio Mariani ◽  
Antonio Di Monaco ◽  
Paolo Compagnucci ◽  
...  
Keyword(s):  
Heart Disease ◽  
Clinical Practice ◽  
Scientific Evidence ◽  
Structural Heart Disease ◽  
Premature Ventricular Contractions ◽  
Stepwise Approach ◽  
Diagnostic Work ◽  
The Right ◽  
Work Up ◽  
Diagnostic Work Up

Premature ventricular contractions in the absence of structural heart disease are among the most common arrhythmias in clinical practice, with well-defined sites of origin in the right and left ventricle. In this review, starting from the electrocardiographic localization of premature ventricular contractions, we investigated the mechanisms, prevalence in the general population, diagnostic work-up, prognosis and treatment of premature ventricular contractions, according to current scientific evidence.

scholarly journals Indication and outcome of lupus anticoagulant and antiphospholipid antibodies testing in routine clinical practice

2021 ◽  
Author(s):  
Eva K Kempers ◽  
Virgil A S H Dalm ◽  
Marie Josee E van Rijn ◽  
Annemarie G M G J Mulders ◽  
Frank W G Leebeek ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Autoimmune Diseases ◽  
Antiphospholipid Antibodies ◽  
Arterial Thrombosis ◽  
Lupus Anticoagulant ◽  
Routine Clinical Practice ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Abstract Objective Lupus anticoagulant (LAC) and antiphospholipid antibodies (aPL), both further summarized as aPL, are frequently assessed in routine daily clinical practice in diagnostic work-up for suspected autoimmune diseases or to test for underlying risk factors in patients with thrombosis or obstetric complications. The aim of this study is to determine the prevalence of aPL positivity in patients with an indication for aPL testing in routine clinical practice. Methods In this retrospective single center study indication for aPL testing, aPL test results and clinical data were collected for patients tested between June 2015 and April 2018. Results During the study period, 16,847 single aPL tests were performed in 2,139 patients. In 212 patients ≥1 positive aPL test was found, confirmed in 43.9% with a second positive test. Indications for aPL testing were diagnostic work-up/follow-up of autoimmune diseases (33.6%), thrombosis (21.4%) and obstetrical complications (28%). Seventy-four patients (3.5% of all patients) fulfilled the criteria of the antiphospholipid syndrome (APS), of whom 51% were newly diagnosed. Second positive aPL titers and titers of APS patients were significantly higher compared with positive aPL titers at first measurement (p < 0.05). Patients with indication arterial thrombosis and diagnostic work-up/follow-up of autoimmune diseases had significantly higher levels of aCL IgG and anti-β2GPI IgG compared with patients with other indications. Conclusion Prevalence of ≥ 1 positive aPL test was 9.9% and APS was diagnosed in 3.5% of the patients. Patients with arterial thrombosis had significantly higher anti-β2GPI IgG and aCL IgG, which should be confirmed in future studies.

scholarly journals Initial Diagnostic Work-Up of Acute Leukemia: ASCO Clinical Practice Guideline Endorsement of the College of American Pathologists and American Society of Hematology Guideline

2019 ◽  
Vol 37 (3) ◽  
pp. 239-253 ◽  
Author(s):  
Valérie de Haas ◽  
Nofisat Ismaila ◽  
Anjali Advani ◽  
Daniel A. Arber ◽  
Raetasha S. Dabney ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Acute Leukemia ◽  
Expert Panel ◽  
Residual Disease ◽  
Target Therapy ◽  
Record Keeping ◽  
American Society ◽  
Diagnostic Work ◽  
Work Up ◽  
Diagnostic Work Up

Purpose The College of American Pathologists (CAP) and the American Society of Hematology (ASH) developed an evidence-based guideline on the initial diagnostic work-up of acute leukemia (AL). Because of the relevance of this topic to the ASCO membership, ASCO reviewed the guideline and applied a set of procedures and policies for endorsing clinical practice guidelines that have been developed by other professional organizations. Methods The CAP-ASH guideline on initial diagnostic work-up of AL was reviewed for developmental rigor by methodologists. Then, an ASCO Endorsement Expert Panel updated the literature search and reviewed the content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the guideline, published in 2016, are clear, thorough, and based on the most relevant scientific evidence. ASCO fully endorsed the CAP-ASH guideline on initial diagnostic work-up of AL and included some discussion points according to clinical practice and updated literature. Conclusion Twenty-seven guideline statements were reviewed. Some discussion points were included to better assess CNS involvement in leukemia and to provide novel insights into molecular diagnosis and potential markers for risk stratification and target therapy. These discussions are categorized into four sections: (1) initial diagnosis focusing on basic diagnostics and determination of risk parameters, (2) molecular markers and minimal residual disease detection, (3) context of referral to another institution with expertise in the management of AL, and (4) reporting and record keeping for better outlining and follow-up discussion. Additional information is available at: www.asco.org/hematologic-malignancies-guidelines .

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