Author Correction: ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics

Abstract H460/MX20 are derived from large cell lung cancer H460 cell line and then transformed into ABCG2-overexpressing cells by mitoxantrone’s induction, which are widely used in study of multidrug resistance (MDR) in vitro. To establish and spread the model of H460/MX20 cell xenografts, we investigated whether cell biological characteristics and the MDR phenotype were maintained in vivo model. Our results demonstrated that the cell proliferation, cell cycle, and ABCG2 expression level in xH460/MX20 cells isolated from H460/MX20 cell xenografts were similar to H460/MX20 cells in vitro. Importantly, xH460/MX20 cells exhibited high levels of resistance to ABCG2 substrates such as mitoxantrone and topotecan as H460/MX20 cells did. Furthermore, lapatinib, the inhibitor of ABCG2, potently reversed mitoxantrone- and topotecan-resistance of xH460/MX20 cells. Taken together, these results suggest that H460/MX20 cell xenografts in athymic nude mice still retain their original cytological characteristics and MDR phenotype. Thus, the H460/MX20 cell xenografts model could serve as a sound model in vivo for study on reversal MDR.

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Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s042482010005384x ◽

1982 ◽

Vol 40 ◽

pp. 236-237

Author(s):

E.C. Chew ◽

C.L. Li ◽

D.P. Huang ◽

H.C. Ho ◽

L.S. Mak ◽

...

Keyword(s):

Cell Line ◽

Nude Mice ◽

Biopsy Specimen ◽

Epithelial Cell Line ◽

Present Communication ◽

Recurrent Tumour ◽

Athymic Nude Mice ◽

Cell Line Establishment ◽

Fine Structures ◽

Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

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972: Antisense CK2 Gene Therapy Induces Regression in Human Bladder Cancer Growing in Athymic Nude Mice

The Journal of Urology ◽

10.1016/s0022-5347(18)38209-0 ◽

2004 ◽

Vol 171 (4S) ◽

pp. 257-258

Author(s):

Joel Slaton ◽

Daniel Sloper ◽

Miriam Taylor ◽

Alan Davis ◽

Khalil Ahmed

Keyword(s):

Gene Therapy ◽

Bladder Cancer ◽

Nude Mice ◽

Human Bladder Cancer ◽

Human Bladder ◽

Athymic Nude Mice

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Integration of viral sequences into the c-myc gene in two mammary adenocarcinomas induced by polyomavirus in athymic nude mice.

Journal of Virology ◽

10.1128/jvi.69.10.5935-5945.1995 ◽

1995 ◽

Vol 69 (10) ◽

pp. 5935-5945 ◽

Cited By ~ 1

Author(s):

M Berebbi ◽

C Cajean-Feroldi ◽

F Apiou ◽

J Couturier ◽

M Garcette ◽

...

Keyword(s):

Nude Mice ◽

Athymic Nude Mice ◽

Myc Gene ◽

Viral Sequences ◽

Mammary Adenocarcinomas

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ELEVATED 1,25(OH)2D3 RECEPTORS IN SKIN OF ATHYMIC NUDE MICE

Vitamin D ◽

10.1515/9783110850345-031 ◽

1991 ◽

pp. 104-105

Keyword(s):

Nude Mice ◽

Athymic Nude Mice

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The Relative Efficacy of Lycopene and β-Carotene in Inhibiting Experimental Metastasis of Human Hepatoma SK-Hep-1 Cells in Athymic Nude Mice

Journal of Nutrition ◽

10.1093/jn/138.11.2289 ◽

2008 ◽

Vol 138 (11) ◽

pp. 2289-2289 ◽

Cited By ~ 4

Author(s):

Ching Kuang Chow

Keyword(s):

Nude Mice ◽

Human Hepatoma ◽

Relative Efficacy ◽

Experimental Metastasis ◽

Athymic Nude Mice ◽

Β Carotene

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MAINTENANCE OF SKIN XENOGRAFTS OF WIDELY DIVERGENT PHYLOGENETIC ORIGIN ON CONGENITALLY ATHYMIC (NUDE) MICE

Journal of Experimental Medicine ◽

10.1084/jem.138.2.488 ◽

1973 ◽

Vol 138 (2) ◽

pp. 488-494 ◽

Cited By ~ 102

Author(s):

Dean D. Manning ◽

Norman D. Reed ◽

Charles F. Shaffer

Keyword(s):

Nude Mice ◽

Tree Frog ◽

Skin Grafts ◽

Intact Skin ◽

Athymic Nude Mice ◽

Phylogenetic Origin ◽

Definitive Role

Congenitally athymic (nude) mice accepted for their lifetime intact skin grafts from distantly related mammals (cat, human) and birds (chicken). They also failed to immunologically reject skin grafts from reptiles (lizards) and amphibians (tree frog), although the skin in these grafts underwent varying degrees of disorganization. A definitive role for the thymic defect in this failure to reject xenografts was established by showing that thymus implantation into nude mice enabled them to reject such foreign skin.

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