Depressive rumination has been conceptualized as a mental habit that is initiated automatically without conscious awareness, intent or control in response to negative mood. However, it is unknown whether depression vulnerability is characterized by elevated levels of mood-reactive rumination at the level of short-term dynamics. Using mobile ecological momentary assessment, formerly depressed individuals with a recurrent history of depression (n = 94) and non-clinical controls (n = 55) recorded in-the-moment affect and rumination ten times daily over six days, after completing measures of trait ruminative brooding, early-life stress, and habitual characteristics of negative thinking (e.g., automaticity, lack of conscious awareness, intent, and control). Momentary fluctuations in negative affect were prospectively associated with greater rumination at the next sampling occasion in formerly depressed participants whereas this pattern was not observed in non-clinical controls. In formerly depressed participants, the degree of mood-reactivity was moderated by habitual characteristics of negative thinking, which interacted with a history of early-life stress in predicting greater mood-reactive rumination. It was not, however, associated with depression course nor with the frequency of trait ruminative brooding. Mood-reactive rumination may be a vulnerability marker for depression, triggered in response to negative affect with a high degree of automaticity, making it difficult to control. It might constitute a risk independent of the depressive course and originate in early-life stress. Future studies may need to go beyond frequency and target the mood-reactivity and automaticity of ruminative thinking to reduce depression vulnerability
Early-life stress affects drug abuse susceptibility in adolescent rat model independently of depression vulnerability
