scholarly journals Upper gastrointestinal tract involvement is more prevalent in Korean patients with pediatric Crohn’s disease than in European patients

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Eun Sil Kim ◽  
Yiyoung Kwon ◽  
Yon Ho Choe ◽  
Mi Jin Kim
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Disease Outcome ◽  
Disease Phenotype ◽  
Gi Tract ◽  
Korean Patients ◽  
Upper Gi ◽  
Tract Involvement ◽  
Upper Gastrointestinal ◽  
Upper Gi Tract

Abstract In pediatric Crohn’s disease (CD) patients, it is important to define the disease phenotype at diagnosis for stratifying risk. In this retrospective study, we aimed to assess the disease phenotype compared to EUROKIDS registry and analyze disease outcome of pediatric CD patients according to upper gastrointestinal (GI) tract involvement. A total of 312 patients were included. The median age at diagnosis was 13.7 years and 232 patients (74.4%) were identified to have upper GI involvement at diagnosis. In Korean pediatric CD patients, there were significant differences in male predominance (72.8% vs. 59.2, p < 0.001), proportion of upper GI involvement (74.4% vs. 46.2%, p < 0.001), and perianal disease (62.1% vs. 8.2%, p < 0.001) compared to data in the EUROKIDS registry. Younger age (OR 2.594, p = 0.0139) and ileal involvement (OR 2.293, p = 0.0176) at diagnosis were associated with upper GI involvement. There were no significant differences in disease outcomes between patients with and without upper GI tract involvement. This study revealed that upper GI involvement is more prevalent in Korean patients with pediatric Crohn’s disease than in European patients, and the disease outcome did not appear to differ according to upper GI tract involvement.

scholarly journals 81. UPPER GI TRACT INVOLVEMENT IN CHILDREN WITH CROHN'S DISEASE

1987 ◽  
Vol 22 (1) ◽  
pp. 109-109
Author(s):  
C Lenaerts ◽  
A M Weber ◽  
C Maurage ◽  
D Belli ◽  
C C Roy
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gi Tract ◽  
Upper Gi ◽  
Tract Involvement ◽  
Upper Gi Tract

scholarly journals P207 Prevalence and characteristics of Romanian patients with upper GI tract involvement in Crohn's disease

2017 ◽  
Vol 11 (suppl_1) ◽  
pp. S181-S181
Author(s):  
A. Dimitriu ◽  
S. Ichim ◽  
M. Cojocaru ◽  
C. Gheorghe ◽  
M. Diculescu ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gi Tract ◽  
Upper Gi ◽  
Tract Involvement ◽  
Upper Gi Tract

T1217 Endomicroscopy Can Readily Identify In Vivo Dysfunctional Cell Shedding and Local Barrier Dysfunction in the Upper GI-Tract of Patients With Crohn's Disease

2010 ◽  
Vol 138 (5) ◽  
pp. S-513
Author(s):  
Lee Guan Lim ◽  
Janina Patricia Neumann ◽  
Martin Goetz ◽  
Arthur Hoffman ◽  
Markus F. Neurath ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gi Tract ◽  
Barrier Dysfunction ◽  
Upper Gi ◽  
Cell Shedding ◽  
Upper Gi Tract

Su1824 Endoscopic Dilation for Primary Crohn's Disease Strictures in the Upper GI Tract: Efficacy, Safety and Long Term Outcome

2016 ◽  
Vol 150 (4) ◽  
pp. S563 ◽  
Author(s):  
Amandeep Singh ◽  
Neha Agrawal ◽  
Satya V. Kurada ◽  
Rocio Lopez ◽  
Bret Lashner ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Endoscopic Dilation ◽  
Gi Tract ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Upper Gi ◽  
Upper Gi Tract

Upper Gastrointestinal Langerhans Cell Histiocytosis: A Report of 2 Adult Cases and a Literature Review

2020 ◽  
pp. 106689692096456
Author(s):  
Yui Matsuoka ◽  
Yoshiki Iemura ◽  
Masakazu Fujimoto ◽  
Shinsuke Shibuya ◽  
Atsushi Yamada ◽  
...  
Keyword(s):  
Langerhans Cell Histiocytosis ◽  
Mononuclear Cells ◽  
Malignant Neoplasm ◽  
Langerhans Cell ◽  
Braf V600e ◽  
Gi Tract ◽  
Upper Gi ◽  
Upper Gastrointestinal ◽  
Upper Gi Tract

Langerhans cell histiocytosis (LCH) with primary involvement of the upper gastrointestinal (GI) tract is rare. We report 2 adult cases of localized LCH in the upper-GI tract, including the second reported adult case of esophageal LCH and review 11 previously reported cases. Case 1 involved the esophagus of a 61-year-old man; histiocytosis was detected when endoscopy was performed for an examination of epigastric pain. Case 2 involved the stomach of a 56-year-old woman wherein the lesion was detected during a follow-up endoscopy after Helicobacter pylori infection. Both biopsy specimens exhibited diffuse proliferation of mononuclear cells with nuclear convolution and a background of eosinophilic infiltrate. The cells were immunohistochemically positive for CD1a and langerin, and BRAF V600E mutation was detected in Case 2. Follow-up endoscopy for both cases revealed that the lesions disappeared without any treatment. It is important to avoid misdiagnosing LCH of the upper-GI tract as a malignant neoplasm.

Tu1225 Upper Gastrointestinal Tract Involvement in Crohn's Disease Requiring Anti-TNF Therapy: Clinical Characteristics

2012 ◽  
Vol 142 (5) ◽  
pp. S-779
Author(s):  
William J. Tremaine ◽  
William A. Faubion ◽  
Darrell S. Pardi ◽  
Lawrence J. Timmons ◽  
Sunanda V. Kane ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Clinical Characteristics ◽  
Upper Gastrointestinal Tract ◽  
Tract Involvement ◽  
Upper Gastrointestinal

scholarly journals Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe ComplicatedClostridium difficileInfection in Elderly Patients in Poor Medical Condition: The First Study in an Asian Country

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Tae-Geun Gweon ◽  
Jinsu Kim ◽  
Chul-Hyun Lim ◽  
Jae Myung Park ◽  
Dong-Gun Lee ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Fecal Microbiota Transplantation ◽  
Medical Condition ◽  
Performance Status ◽  
Fecal Microbiota ◽  
Gi Tract ◽  
Upper Gi ◽  
Low Performance ◽  
Upper Gastrointestinal ◽  
Upper Gi Tract

Background and Aims. Fecal microbiota transplantation (FMT) is a highly effective treatment option for refractoryClostridium difficileinfection (CDI). FMT may be challenging in patients with a low performance status, because of their poor medical condition. The aims of this study were to describe our experience treating patients in poor medical condition with refractory or severe complicated CDI using FMT via the upper GI tract route.Methods. This study was a retrospective review of seven elderly patients with refractory or severe complicated CDI and a poor medical condition who were treated with FMT through the upper GI tract route from May 2012 through August 2013. The outcomes studied included the cure rate of CDI and adverse events.Results. Of these seven patients who received FMT via the upper GI tract route, all patients were cured. During the 11-month follow-up period, CDI recurrence was observed in two patients; rescue FMT was performed in these patients, which led to a full cure. Vomiting was observed in two patients.Conclusions. FMT via the upper gastrointestinal tract route may be effective for the treatment of refractory or severe complicated CDI in patients with a low performance status. Physicians should be aware of adverse events, especially vomiting.

scholarly journals Upper Gastrointestinal Tract Involvement in Crohn’s Disease: Frequency, Risk Factors, and Disease Course

2018 ◽  
Vol 12 (12) ◽  
pp. 1399-1409 ◽  
Author(s):  
Thomas Greuter ◽  
Alberto Piller ◽  
Nicolas Fournier ◽  
Ekaterina Safroneeva ◽  
Alex Straumann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Upper Gastrointestinal Tract ◽  
Disease Course ◽  
Tract Involvement ◽  
Upper Gastrointestinal
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