Influence of red blood cell indices on HbA1c performance in detecting dysglycaemia in a Singapore preconception cohort study

AbstractAbnormalities of red blood cell (RBC) indices may affect glycated haemoglobin (HbA1c) levels. We assessed the influence of haemoglobin (Hb) and mean corpuscular volume (MCV) on the performance of HbA1c in detecting dysglycaemia among reproductive aged women planning to conceive. Women aged 18–45 years (n = 985) were classified as normal (12 ≤ Hb ≤ 16 g/dL and 80 ≤ MCV ≤ 100 fL) and abnormal (Hb < 12 g/dL and/or MCV < 80 fL). The Area Under the Receiver Operating Characteristic (AUROC) curve was used to determine the performance of HbA1c in detecting dysglycaemic status (prediabetes and diabetes). There were 771 (78.3%) women with normal RBC indices. The AUROCs for the normal and abnormal groups were 0.75 (95% confidence interval 0.69, 0.81) and 0.80 (0.70, 0.90), respectively, and were not statistically different from one another [difference 0.04 (− 0.16, 0.08)]. Further stratification by ethnicity showed no difference between the two groups among Chinese and Indian women. However, Malay women with normal RBC indices displayed lower AUROC compared to those with abnormal RBC indices (0.71 (0.55, 0.87) vs. 0.98 (0.93, 1.00), p = 0.002). The results suggest that the performance of HbA1c in detecting dysglycaemia was not influenced by abnormal RBC indices based on low Hb and/or low MCV. However, there may be ethnic variations among them.

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Platelet and Red Blood Cell Indices in Patients with Panic Disorder: A Receiver Operating Characteristic Analysis

Journal of Neurosciences in Rural Practice ◽

10.1055/s-0040-1703422 ◽

2020 ◽

Vol 11 (02) ◽

pp. 261-266 ◽

Cited By ~ 2

Author(s):

Ramdas S. Ransing ◽

Neha Gupta ◽

Girish Agrawal ◽

Nilima Mahapatro

Keyword(s):

Panic Disorder ◽

Blood Cell ◽

Receiver Operating Characteristic ◽

Red Blood Cell ◽

Roc Curve ◽

Operating Characteristic ◽

Healthy Controls ◽

Distribution Width ◽

Rbc Indices ◽

Receiver Operating

Abstract Objective Panic disorder (PD) is associated with changes in platelet and red blood cell (RBC) indices. However, the diagnostic or predictive value of these indices is unknown. This study assessed the diagnostic and discriminating value of platelet and RBC indices in patients with PD. Materials and Methods In this cross-sectional study including patients with PD (n = 98) and healthy controls (n = 102), we compared the following blood indices: mean platelet volume (MPV), platelet distribution width (PDW), and RBC distribution width (RDW). The receiver operating characteristic (ROC) curve was used to calculate the area under the ROC curve (AUC), sensitivity, specificity, and likelihood ratio for the platelet and RBC indices. Results Statistically significant increase in PDW (17.01 ± 0.91 vs. 14.8 ± 2.06; p < 0.0001) and RDW (16.56 ± 2.32 vs. 15.12 ± 2.43; p < 0.0001) levels were observed in patients with PD. PDW and mean corpuscular hemoglobin concentration had larger AUC (0.89 and 0.74, respectively) and Youden’s index (0.65 and 0.39, respectively), indicating their higher predictive capacity as well as higher sensitivity in discriminating patients with PD from healthy controls. Conclusion PDW can be considered a “good” diagnostic or predictive marker in patients with PD.

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Iron Intake, Hemoglobin Level, and Red Blood Cell Indices in Adolescents with Obesity

Journal Of Medicine & Health ◽

10.28932/jmh.v2i1.742 ◽

2018 ◽

Vol 2 (1) ◽

Author(s):

Aviyani Aviyani ◽

Ginna Megawati ◽

Susi Susannah

Keyword(s):

Iron Deficiency ◽

Blood Cell ◽

Red Blood Cell ◽

Hemoglobin Level ◽

Deficiency Anemia ◽

Iron Intake ◽

Rbc Indices ◽

Red Blood Cell Indices ◽

Male Subjects ◽

Female Subjects

Obesity is a condition of excess and abnormal fat accumulation. Obese adolescents are atgreater risk of developing iron deficiency anemia with microcytic hypochromic red blood cells(RBC). Iron deficiency in obesity relates to low iron intake, abnormal iron absorption, andincreased iron utilization. The aim of this study was to determine iron intake, hemoglobin level,and RBC indices in faculty of medicine students with obesity. We used descriptive cross-sectional method, involving year of 2016 students in Faculty of Medicine PadjadjaranUniversity with obesity. Pregnant women and students with previous history of thallasemia oranemia were excluded. Iron intake was assessed using Food Frequency Questionnaire.Hemoglobin level and RBC indices were measured in Hasan Sadikin General Hospital. Ironintake of male subjects were adequate in 62,5% subjects and low in 37,5% subjects. Iron intakein female subjects were adequate in 20% subjects and low in 80% subjects. Male hemoglobinlevel were normal and 20% of female subjects had anemia. All male subjects were normochromnormocytic, 40% female subjects were hypochrom microcytic.Keywords: adolescents, hemoglobin level, iron intake, obesity, red blood cell indices

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