Efficacy on radiofrequency ablation according to the types of benign thyroid nodules

AbstractPercutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 262 ones with solid nodules and 1027 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.

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Radiofrequency Ablation for Benign Thyroid Nodules: Efficacy According to the Types of Thyroid Nodules

10.21203/rs.3.rs-107864/v1 ◽

2020 ◽

Author(s):

Jianhua Li ◽

Wenping Xue ◽

Pengfei Xu ◽

Zhen Deng ◽

Caiwen Duan ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Thyroid Nodules ◽

Reduction Ratio ◽

Invasive Treatment ◽

Solid Nodule ◽

Maximal Diameter ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid ◽

Better Than

Abstract Percutaneous radiofrequency ablation (RFA) has been recommended as minimally invasive treatment for patients with symptomatic benign thyroid nodules (BTNs) because of the large number of clinical applications. This retrospective observational study sought to evaluate the clinical outcomes of RFA for BTNs. From 2014 to 2019, a sample size of 1289 patients treated by RFA were 226 ones with solid nodules and 865 ones with cystic-solid nodule, respectively. The efficacy including the nodule maximal diameter reduction ratio (MDRR), the volume reduction ratio (VRR) and the cosmetic scores reduction ratio (CSRR). The results of the nodule MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month, and the CSRR in the two groups showed statistically significant difference at the 3rd month. In a word, RFA is an effective method for symptomatic benign solid or cystic-solid nodules. The achieved MDRR and VRR in the cystic-solid nodule group were significantly better than those in the solid nodule group at the 3rd and 6th month.

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Ultrasound predictive criteria for short term benign thyroid nodular volume reduction after ultrasound guided radiofrequency ablation

QJM ◽

10.1093/qjmed/hcab106.030 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Khaled Fikry Tawfik Shehab ◽

Ahmed Mohamed Hussein ◽

Rasha Tolba Khattab

Keyword(s):

Thyroid Nodules ◽

Reduction Ratio ◽

Volume Reduction ◽

Body Sensation ◽

Significant Difference ◽

Noticeable Improvement ◽

Us Findings ◽

Benign Thyroid Nodules ◽

Benign Thyroid ◽

Ultrasound Features

Abstract Purpose This study evaluates the outcome of patients complaining of compressive& cosmetic problems due to benign thyroid nodules after recieving RF ablation with correlation between some ultrasound features of the nodules and their shrinkage and volume reduction. Methods and material fifteen patients with benign thyroid nodules causing compressive symptoms (foreign body sensation,neck discomfort or pain) and cosmetic problems. Results A total of 15 patients were included with the age rangmg from 22-82 years old the mean was 52.73 years old (SD + 14.37).Among them 12 patients (800 0)were females and 3 patients(20%) were males. There was statistically significant difference between volume of nodules before the procedure with mean volume was 21.13±5.13 and I month after with mean volume I I .96±3.08 and 3 months after the procedure with mean volume 7.70±2.82 with noticeable improvement in nodules with peri and intranodular vascularity showing mean reduction ratio 69.88% after 3 months vs 59.93% and 64 12% of weak peripheral vascularity and intense intra-nodular vasculanty respectively as well as US structure with spongiform nodules showing mean reduction ratio 68.48% at 3 months vs 59.87% and 62.14% for solid &mixed nodules respectively.Mean symptoms and cosmetic score were significantly reduced. Conclusion: This study validated the efficacy and safety of RFA for treatment of benign thyroid nodules and showed correlation between shrinkage and some common US findings.

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Efficacy and safety of ultrasound (US)-guided radiofrequency ablation of benign thyroid nodules

Egyptian Journal of Radiology and Nuclear Medicine ◽

10.1186/s43055-021-00435-y ◽

2021 ◽

Vol 52 (1) ◽

Author(s):

Mai S. Abd El-Galil ◽

Ali H. Ali ◽

Raef M. Botros ◽

Yasser I. Abd El-Khaleq ◽

Osama M. A. Hetta

Keyword(s):

Radiofrequency Ablation ◽

Thyroid Function ◽

Thyroid Nodules ◽

Volume Reduction ◽

Rf Ablation ◽

Efficacy And Safety ◽

Invasive Treatment ◽

Life Threatening ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Abstract Background We evaluated 45 benign thyroid nodules of 40 patients treated with radiofrequency (RF) ablation and followed up for 6 months. The inclusion criteria included unilateral or bilateral thyroid nodules with compression symptoms or cosmetic problems, cytological confirmation of benignity without atypical cells, and patient refusal or unfit for surgery. There was no predilection for the size, number, ultrasound nature of the nodules, (solid, cystic, or complex). RF ablation was performed using Mygen (M-3004) RF generator from RF Medical Co., Ltd, South Korea. The volume of the nodules and clinical problems were evaluated before and after the procedure. Complications and factors related to volume reduction were evaluated. The purpose of the study is to evaluate the efficacy and safety of US-guided radiofrequency (RF) ablation in the treatment of benign thyroid nodules. Results The volume reduction ratio (%) of the thyroid nodules was statistically significant. The mean VRR was 58.41 ± 15.27SD at 1 month, 73.26 ± 11.22SD at 3 months, and 82.54 ± 12.49SD at 6 months. P value was < 0.001. The radiofrequency ablation did not affect the normal thyroid function of the 38 patients who were euthyroid at the start of the study. Thyroid function normalized 1 month after ablation of the two autonomously functioning thyroid nodules. The compressive symptoms resolved in 22 patients (55%) and improved in the rest of the 18 patients (45%) with the median decreased from 8 (IQR 6–9), range 4–10 before treatment to 0 (IQR 0–1), range 0–3 after 6 months. Cosmetic problems improved in all 40 patients by P value < 0.001. The procedure had no sustained or life-threatening complications. Conclusions RF ablation was effective in reducing the size of the benign thyroid nodules and in controlling nodule-related compressive symptoms as well as cosmetic problems. There were no major complications sustained and no life-threatening complications or sequelae happened. RF ablation can be used as an alternative non-surgical minimally invasive treatment for patients with benign thyroid nodules.

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Multicenter Study of Benign Thyroid Nodules with Radiofrequency Ablation: Results of 762 Cases over 4 Years in Taiwan

Journal of Personalized Medicine ◽

10.3390/jpm12010063 ◽

2022 ◽

Vol 12 (1) ◽

pp. 63

Author(s):

Wei-Che Lin ◽

Cheng-Kang Wang ◽

Wen-Hung Wang ◽

Chi-Yu Kuo ◽

Pi-Ling Chiang ◽

...

Keyword(s):

Radiofrequency Ablation ◽

Multicenter Study ◽

Thyroid Nodules ◽

The Other ◽

Ultrasound Guided ◽

Medical Centers ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid

Background: To evaluate the effectiveness and safety of radiofrequency ablation (RFA) treatment for benign thyroid nodules (BTNs) in five medical centers in Taiwan. Methods: From April 2016 to July 2020, 762 patients underwent ultrasound guided RFA treatment of 826 benign thyroid nodules at five medical centers in Taiwan. The RFA procedure was performed by radiologists, otolaryngologists, or surgeons. Patients were grouped into three subgroups according to the initial volume of BTNs. The volume reduction ratio (VRR) of each nodule, and complications were analyzed at 1, 3, and 6 months after RFA treatment and the three groups compared. Results: The large nodular group showed greater VRR compared to the other two groups at first 1-month follow-up. At 6-months follow-up, there was no significant difference of VRR among the three groups. Goiters with difference in size can attain a successful VRR (>50%) although different specialists demonstrated variable VRR after 6-months follow-up. A total of 40 (4.8%) complications were reported. All patients recovered spontaneously without surgery intervention. Conclusions: The reliability and safety of RFA for benign thyroid nodules had been established. RFA has gradually become an alternative to surgery in the treatment of benign thyroid nodules in Taiwan.

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A Propensity Score Matching Study Between Microwave Ablation and Radiofrequency Ablation in Terms of Safety and Efficacy for Benign Thyroid Nodules Treatment

Frontiers in Endocrinology ◽

10.3389/fendo.2021.584972 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hao Jin ◽

Jinrui Fan ◽

Ligong Lu ◽

Min Cui

Keyword(s):

Radiofrequency Ablation ◽

Propensity Score ◽

Propensity Score Matching ◽

Microwave Ablation ◽

Thyroid Nodules ◽

Complication Rates ◽

Safety And Efficacy ◽

Significant Difference ◽

Benign Thyroid Nodules ◽

Benign Thyroid

BackgroundLarge benign thyroid nodules often lead to cosmetic problems and compression on trachea. Thermal ablation is an effective method for benign thyroid nodules treatment. Among all the thermal ablation techniques, microwave and radiofrequency are frequently used energy sources. However, treatment outcomes of the two ablation types have not been compared in detail. Therefore, we conducted this study aiming for comparing the safety and efficacy of the two ablation techniques in benign thyroid nodules treatment.MethodsInformation was retrospectively collected from patients with benign thyroid nodules, who received radiofrequency ablation or microwave ablation between January 1, 2018, and December 31, 2019, in a main hospital in South China. Patients were divided into microwave ablation group and radiofrequency ablation group according to the techniques applied. A propensity score matching was performed to balance the baseline indexes between the two groups. We also recorded and analyzed the operative variables including operative duration, intraoperative blood loss, hospitalization time, and overall costs. Postoperative quality of life, volume reduction rates, and complication rates were routinely evaluated during the follow-up by asking patients to fulfil questionnaires at the 1st, 3rd, 6th, 12th, and 18th postoperative month.ResultsA total of 943 patients receiving microwave ablation or radiofrequency ablation in the years of 2018 and 2019 met our inclusion criteria. After 1:1 propensity score matching, 289 pairs of patients were matched. There was no significant difference between the two groups in operative duration, intraoperative blood loss, hospitalization time, overall cost, quality of life scores, complication rates or volume reduction rates.ConclusionThere was no significant difference between microwave and radiofrequency ablation in terms of safety and efficacy. Both of the two techniques` are ideal therapeutic methods in benign thyroid nodules treatment.Registration numberChiCTR2000034764.

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