Quantification of contrast agent uptake in the hepatobiliary phase helps to differentiate hepatocellular carcinoma grade

AbstractThis study aimed to assess the degree of differentiation of hepatocellular carcinoma (HCC) using Gd-EOB-DTPA-assisted magnetic resonance imaging (MRI) with T1 relaxometry. Thirty-three solitary HCC lesions were included in this retrospective study. This study's inclusion criteria were preoperative Gd-EOB-DTPA-assisted MRI of the liver and a histopathological evaluation after hepatic tumor resection. T1 maps of the liver were evaluated to determine the T1 relaxation time and reduction rate between the native phase and hepatobiliary phase (HBP) in liver lesions. These findings were correlated with the histopathologically determined degree of HCC differentiation (G1, well-differentiated; G2, moderately differentiated; G3, poorly differentiated). There was no significant difference between well-differentiated (950.2 ± 140.2 ms) and moderately/poorly differentiated (1009.4 ± 202.0 ms) HCCs in the native T1 maps. After contrast medium administration, a significant difference (p ≤ 0.001) in the mean T1 relaxation time in the HBP was found between well-differentiated (555.4 ± 140.2 ms) and moderately/poorly differentiated (750.9 ± 146.4 ms) HCCs. For well-differentiated HCCs, the reduction rate in the T1 time was significantly higher at 0.40 ± 0.15 than for moderately/poorly differentiated HCCs (0.25 ± 0.07; p = 0.006). In conclusion this study suggests that the uptake of Gd-EOB-DTPA in HCCs is correlated with tumor grade. Thus, Gd-EOB-DTPA-assisted T1 relaxometry can help to further differentiation of HCC.

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Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

10.21203/rs.2.19955/v1 ◽

2020 ◽

Author(s):

chenyi Rao ◽

Xinquan Wang ◽

Minda Li ◽

Guofeng Zhou ◽

Hongmei Gu

Keyword(s):

Hepatocellular Carcinoma ◽

Relaxation Time ◽

T1 Mapping ◽

Operating Characteristic ◽

Reduction Rate ◽

Gadoxetic Acid ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Enhanced Mri ◽

Adc Values

Abstract Background: To evaluate the utility of non-invasive parameters driving from T1 mapping on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC) compared with diffusion-weighted imaging (DWI).Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was included in the retrospective study, who underwent preoperative gadoxetic acid-enhanced MRI combined with DWI and T1 mapping. Parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and ADC values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters.Results: The mean value of postcontrast T1 relaxation time were significantly higher in MVI-positive HCCs that MVI-negative HCCs (621.0 vs. 536.5, P <0.001). MVI-positive HCCs demonstrated significantly lower reduction rates of T1 relaxation time and lower ADC values than MVI-negative HCCs (39.4% vs 49.9, P<0.001; 1.495×10-3mm2/s vs 1.620×10-3mm2/s, P=0.003, respectively). The area under receiver operating characteristic curves were 0.587, 0.728, 0.824 and 0.690 for precontrast, postcontrast, reduction rate of T1 relaxation time and ADC, respectively. The reduction rate of T1 relaxation time was the most reliable feature with sensitivity, specificity and accuracy of the cut-off value (44.9%) of 79.0%, 73.2%, 75.5%, respectively.Conclusions: Reduction rate of T1 relaxation time on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

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T1 Relaxation Time of Achilles Tendon at 3 Tesla with Special Reference to Relevant Clinical Score: A Preliminary Study

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405615666181205130816 ◽

2020 ◽

Vol 16 (2) ◽

pp. 164-173

Author(s):

Zeineb Tbini ◽

Mokhtar Mars ◽

Mouna Bouaziz

Keyword(s):

Relaxation Time ◽

Achilles Tendon ◽

Clinical Score ◽

3 Tesla ◽

Acquisition Time ◽

Short Term ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Spin Echo Sequence ◽

Significant Difference

Purpose: The purpose of this study was to investigate T1 relaxation time of the human Achilles tendon, to test its short-term repeatability as well as the minimal detectable change, and to assess the extent that correlate with clinical symptoms. Methods: Twenty asymptomatic volunteers and eighteen patients with clinically and sonographically confirmed tendinopathy were scanned for ankle using a 3 Tesla (T) MR scanner. T1 maps were calculated from a variable flip angle gradient echo Ultra-short echo time sequence (VFA-GE UTE) and inversion recovery spin echo sequence (IR-SE) using a self-developed matlab algorithm in three regions of interest of Achilles Tendon (AT). Signal to Noise Ratio (SNR) between the two sequences was evaluated. INTRA-class Correlation Coefficient (ICC), Coefficient of Variation (CV) and the Least Significant Change (LSC) were calculated, to test short-term repeatability of T1. Subjects were assessed by the VISA-A clinical score. P values less than 0.005 were considered statistically significant. Results: Mean T1 values were 427.09 ± 53.37 ms and 528.70 ± 103.50 ms using IR-SE sequence and 575.43 ± 110.60 ms and 875.81 ± 425.77 ms with VFA-GE UTE sequence in the whole AT for volunteers and patients, respectively. : T1 values showed a significant difference between volunteers and patients (P=0.001). Regional variation of T1 in healthy and tendinopathic AT were greater for VFA-GE UTE sequence than for IR-SE sequence. VFA-GE UTE sequence showed clearly higher SNR compared to IR-SE sequence. Short-term repeatability of T1 values for volunteers showed an LSC of 22% and 14% for IR-SE sequence and VFA-GE UTE sequence, respectively. For patients, LSC was 14% and 5% for IR-SE sequence and VFA-GE UTE sequence, respectively. There was no correlation between T1 and VISA-A clinical score (p>0.005). Conclusion: VFA-GE UTE sequence used for T1 mapping calculation demonstrated short acquisition time and clearly high SNR. Results revealed that T1 relaxation time can be used as a biomarker to differentiate between healthy and pathologic Achilles tendon. However, T1 showed no correlation with the VISA-A clinical score.

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Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

10.21203/rs.2.19955/v3 ◽

2020 ◽

Author(s):

chenyi Rao ◽

Xinquan Wang ◽

Minda Li ◽

Guofeng Zhou ◽

Hongmei Gu

Keyword(s):

Relaxation Time ◽

T1 Mapping ◽

Operating Characteristic ◽

Characteristic Curve ◽

Reduction Rate ◽

Gadoxetic Acid ◽

T1 Relaxation Time ◽

Adc Value ◽

T1 Relaxation ◽

Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters derived from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC).Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in this retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters.Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P<0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824, 0,690 and 0.862 for the precontrast, postcontrast, reduction rate of T1 relaxation time, ADC and the combination of reduction rate and ADC, respectively. The cut-off value of the reduction rate and ADC calculated through maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm2. To achieve a better diagnostic performance, the criteria of combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm2 was proposed with a high specificity of 91.8% and accuracy of 80.9%.Conclusions: The proposed criteria of combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

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Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

10.21203/rs.2.19955/v2 ◽

2020 ◽

Author(s):

Chenyi Rao ◽

Xinquan Wang ◽

Minda Li ◽

Guofeng Zhou ◽

Hongmei Gu

Keyword(s):

Relaxation Time ◽

T1 Mapping ◽

Operating Characteristic ◽

Characteristic Curve ◽

Reduction Rate ◽

Gadoxetic Acid ◽

T1 Relaxation Time ◽

Adc Value ◽

T1 Relaxation ◽

Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters driving from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in the retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters. Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P<0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824 and 0,690 for precontrast, postcontrast, reduction rate of T1 relaxation time and ADC, respectively. The cut-off value of the reduction rate and ADC calculated though maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm2. To achieve a better diagnostic performance, the criteria that combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm2 was proposed with a high specificity of 91.8% and accuracy of 80.9%. Conclusions: The criteria that combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

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Value of T1 Mapping on Gadoxetic acid-enhanced MRI for Microvascular Invasion of Hepatocellular Carcinoma: A Retrospective Study

10.21203/rs.2.19955/v4 ◽

2020 ◽

Author(s):

chenyi Rao ◽

Xinquan Wang ◽

Minda Li ◽

Guofeng Zhou ◽

Hongmei Gu

Keyword(s):

Relaxation Time ◽

T1 Mapping ◽

Operating Characteristic ◽

Characteristic Curve ◽

Reduction Rate ◽

Gadoxetic Acid ◽

T1 Relaxation Time ◽

Adc Value ◽

T1 Relaxation ◽

Enhanced Mri

Abstract Background: To evaluate the utility of non-invasive parameters derived from T1 mapping and diffusion-weighted imaging (DWI) on gadoxetic acid-enhanced MRI for predicting microvascular invasion (MVI) of hepatocellular carcinoma (HCC). Methods: A total of 94 patients with single HCC undergoing partial hepatectomy was analyzed in this retrospective study. Preoperative T1 mapping and DWI on gadoxetic acid-enhanced MRI was performed. The parameters including precontrast, postcontrast and reduction rate of T1 relaxation time and apparent diffusion coefficient (ADC) values were measured for differentiating MVI-positive HCCs (n=38) from MVI-negative HCCs (n=56). The receiver operating characteristic curve (ROC) was analyzed to compare the diagnostic performance of the calculated parameters. Results: MVI-positive HCCs demonstrated a significantly lower reduction rate of T1 relaxation time than that of MVI-negative HCCs (39.4% vs 49.9, P <0.001). The areas under receiver operating characteristic curve (AUC) were 0.587, 0.728, 0.824, 0,690 and 0.862 for the precontrast, postcontrast, reduction rate of T1 relaxation time, ADC and the combination of reduction rate and ADC, respectively. The cut-off value of the reduction rate and ADC calculated through maximal Youden index in ROC analyses was 44.9% and 1553.5 s/mm 2 . To achieve a better diagnostic performance, the criteria of combining the reduction rate lower than 44.9% and the ADC value lower than 1553.5 s/mm 2 was proposed with a high specificity of 91.8% and accuracy of 80.9%. Conclusions: The proposed criteria of combining the reduction rate of T1 relaxation time lower than 44.9% and the ADC value lower than 1553.5 s/mm 2 on gadoxetic acid-enhanced MRI holds promise for evaluating MVI status of HCC.

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Physiologic Changes in Breast Magnetic Resonance Imaging during the Menstrual Cycle: Perfusion Imaging, Signal Enhancement, and Influence of the T1 Relaxation Time of Breast Tissue

The Breast Journal ◽

10.1111/j.1075-122x.2005.21499.x ◽

2005 ◽

Vol 11 (4) ◽

pp. 236-241 ◽

Cited By ~ 115

Author(s):

Jean-Paul Delille ◽

Priscilla J. Slanetz ◽

Eren D. Yeh ◽

Daniel B. Kopans ◽

Leoncio Garrido

Keyword(s):

Magnetic Resonance Imaging ◽

Relaxation Time ◽

Menstrual Cycle ◽

Magnetic Resonance ◽

Breast Tissue ◽

Breast Magnetic Resonance Imaging ◽

Resonance Imaging ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Breast Magnetic Resonance

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Blood-brain barrier breakdown in non-enhancing multiple sclerosis lesions detected by 7-Tesla MP2RAGE ΔT1 mapping

PLoS ONE ◽

10.1371/journal.pone.0249973 ◽

2021 ◽

Vol 16 (4) ◽

pp. e0249973

Author(s):

Seongjin Choi ◽

Margaret Spini ◽

Jun Hua ◽

Daniel M. Harrison

Keyword(s):

Multiple Sclerosis ◽

Relaxation Time ◽

White Matter ◽

Blood Brain Barrier ◽

White Matter Lesions ◽

Brain Barrier ◽

7 Tesla ◽

T1 Relaxation Time ◽

T1 Relaxation ◽

Blood Brain

Although the blood-brain barrier (BBB) is altered in most multiple sclerosis (MS) lesions, gadolinium enhancement is seen only in acute lesions. In this study, we aimed to investigate gadolinium-induced changes in T1 relaxation time in MS lesions on 7-tesla (7T) MRI as a means to quantify BBB breakdown in non-enhancing MS lesions. Forty-seven participants with MS underwent 7T MRI of the brain with a magnitude-prepared rapid acquisition of 2 gradient echoes (MP2RAGE) sequence before and after contrast. Subtraction of pre- and post-contrast T1 maps was used to measure T1 relaxation time change (ΔT1) from gadolinium. ΔT1 values were interrogated in enhancing white matter lesions (ELs), non-enhancing white matter lesions (NELs), and normal appearing white matter (NAWM) and metrics were compared to clinical data. ΔT1 was measurable in NELs (median: -0.139 (-0.304, 0.174) seconds; p < 0.001) and was negligible in NAWM (median: -0.001 (-0.036, 0.155) seconds; p = 0.516). Median ΔT1 in NELs correlated with disability as measured by Expanded Disability Status Scale (EDSS) (rho = -0.331, p = 0.026). Multiple measures of NEL ΔT1 variability also correlated with EDSS. NEL ΔT1 values were greater and more variable in patients with progressive forms of MS and greater in those not on MS treatment. Measurement of the changes in T1 relaxation time caused by contrast on 7T MP2RAGE reveals clinically relevant evidence of BBB breakdown in NELs in MS. This data suggests that NEL ΔT1 should be evaluated further as a biomarker for disease severity and treatment effect in MS.

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