Comparison of bipolar plasmakinetic resection of prostate versus photoselective vaporization of prostate by a three year retrospective observational study

AbstractComprehensive evaluation of photoselective vaporization of the prostate (PVP) versus plasmakinetic resection of the prostate (PKRP) in treating benign prostatic hyperplasia (BPH) is inadequate. This single-centre, retrospective observational study was designed to compare their efficacy, complications and sexual function. A total of 215 patients under PVP or PKRP were included in the study, propensity score matching (PSM) was performed to match the baseline characteristics of the two groups, and perioperative and three-year follow-up data were compared between them. Finally, 120 patients (60 for PVP and 60 for PKRP) were matched after PSM. Compared with the PKRP group, the intraoperative haemoglobin loss was lower (9.08 vs 13.75 g/L, P < 0.001) and the duration of catheterization and postoperative hospital stay were shorter (2.97 vs 4.10 day, P < 0.001; 3.95 vs 5.13 day, P < 0.001, respectively), but the operation time was longer (56.72 vs 49, 90 min, P < 0.001) in the PVP group. Urination measurements were improved for both groups after surgery, although no significant differences were found between them during follow-up. Sexual function after surgery was partly increased; however, frequent retrograde and discomfortable ejaculation occurred in both groups. In addition, dysuria incidence and retreatment were higher in the PVP group at 12 months. In conclusion, PVP is safe and effective in relieving BPH-related lower urinary tract symptoms with less perioperative blood loss and earlier recovery without inferior sexual function effects. However, the study is potentially affected by residual unmeasured confounding.

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1216 SEXUAL FUNCTION OUTCOME FOLLOWING PHOTOSELECTIVE VAPORIZATION OF THE PROSTATE: A SHORT TERM FOLLOW-UP STUDY

The Journal of Urology ◽

10.1016/j.juro.2010.02.718 ◽

2010 ◽

Vol 183 (4S) ◽

Author(s):

Tania Hossack ◽

Henry Woo

Keyword(s):

Sexual Function ◽

Short Term ◽

Follow Up Study ◽

Photoselective Vaporization

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A prospective, observational study on conversion of Clinically Isolated Syndrome to Multiple Sclerosis during 4-year period (MS NEO study) in Taiwan

10.1101/385898 ◽

2018 ◽

Author(s):

Long-Sun Ro ◽

Chih-Chao Yang ◽

Rong-Kuo Lyu ◽

Kon-Ping Lin ◽

Tzung-Chang Tsai ◽

...

Keyword(s):

Observational Study ◽

Conversion Rate ◽

Prognostic Significance ◽

Risk Indicators ◽

Clinical Event ◽

First Episode ◽

Conversion Rates ◽

Demyelinating Lesions ◽

Baseline Characteristics

AbstractImportanceCIS to MS conversion rates vary depending on population cohorts, initial manifestations, and durations of follow-up.ObjectiveTo investigate conversion rate of patients from CIS to MS and the prognostic significance of demographic and clinical variables in Taiwanese population.DesignNationwide, prospective, multi-centric, observational study from November 2008 to November 2014 with 4 years follow-up.SettingMulti-centre setting at 5 institutions in Taiwan.Participants152 patients having single clinical event potentially suggestive of MS in last 2 years were enrolled as consecutive sample. 33 patients were lost to follow-up and 16 patients did not complete the study.103 patients completed the study.Intervention(s) (for clinical trials) or Exposure(s) (for observational studies)Natural progression from first episode of CIS to MS or NMO was observed.Main Outcome(s) and Measure(s)Variables analysed were ‘proportion of patients converting to MS or NMO after first episode of CIS’, ‘duration between first episode of neurological event and diagnosis of MS’, ‘status of anti-AQP4 IgG’ and ‘length of longest contiguous spinal cord lesion in MS patients’. Association between baseline characteristics and progression to MS from CIS was analyzed using multiple logistic regression. Multivariate time dependent effect of baseline characteristics on progression to MS was plotted.Results14.5% patients with CIS converted to MS after 1.1 ± 1.0 years with greater predisposition (18.8%) in those having syndromes referable to the cerebral hemispheres. Conversion rate from ON to MS was 9.7%. 90.9% patients had benign disease course. 46.7% patients had abnormal MRIs at baseline, with 0.6±0.5 contrast enhanced lesions. ‘Below normal BMI’ and ‘MRI lesion load (≥ 4 lesions)’ were identified as risk indicators for the development of MS. Only 4.5% were positive for anti-AQP4 antibody in MS patients and amongst them, 80% were NMO patients as diagnosed by modern criteria.Conclusions and Relevance‘Below normal BMI’ and ‘number of demyelinating lesions (≥4)’ are significant predictors of conversion from CIS to MS. A low conversion rate to MS in Taiwanese CIS patients and majority of them having a benign course and minimal disability suggest the roles of geographic, genetic and ethnic factors.Trial RegistrationNon-trial observational study.

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Routine Follow-Up Radiographs for Ankle Fractures Seldom Add Value to Clinical Decision-Making: A Retrospective, Observational Study

The Journal of Foot & Ankle Surgery ◽

10.1053/j.jfas.2018.03.035 ◽

2018 ◽

Vol 57 (5) ◽

pp. 957-960 ◽

Cited By ~ 8

Author(s):

Pieter van Gerven ◽

Nikki L. Weil ◽

Marco F. Termaat ◽

Sidney M. Rubinstein ◽

Mostafa El Moumni ◽

...

Keyword(s):

Decision Making ◽

Observational Study ◽

Clinical Decision Making ◽

Clinical Decision ◽

Ankle Fractures ◽

Retrospective Observational Study

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The Effects of Unsupervised Home-based Exercise Upon Functional Capacity After 6 Months of Discharge From Cardiac Rehabilitation: A Retrospective Observational Study

Journal of Physical Activity and Health ◽

10.1123/jpah.2016-0058 ◽

2016 ◽

Vol 13 (11) ◽

pp. 1230-1235 ◽

Cited By ~ 4

Author(s):

Juliana Pereira Borges ◽

Mauro Felippe Felix Mediano ◽

Paulo Farinatti ◽

Marina Pereira Coelho ◽

Pablo Marino Correa Nascimento ◽

...

Keyword(s):

Observational Study ◽

Cardiac Rehabilitation ◽

Body Mass ◽

Aerobic Capacity ◽

Exercise Intervention ◽

Retrospective Observational Study ◽

Anthropometric Data ◽

Maximal Aerobic Capacity ◽

Home Based

Background:It remains unclear whether self-regulated exercise is sufficient to maintain the benefits acquired during formal cardiac rehabilitation (CR). This retrospective observational study investigated the effects of a home-based exercise intervention after discharge from CR upon anthropometric and aerobic capacity markers in clinically stable patients.Methods:Fifty patients with cardiovascular disease were discharged after 6 months of CR and encouraged to maintain aerobic exercise without supervision. Subsequent to 6 months of follow-up, patients were assigned to compliant (n = 34) or noncompliant (n = 16) groups according to their compliance to the home-based program. Maximal aerobic capacity (VO2peak) and anthropometric data were assessed before CR, at discharge, and after 6 months of follow-up.Results:No statistical differences between compliant and noncompliant groups were observed at baseline and at discharge from CR. At the end of the follow-up, statistical differences across groups were not found for body mass or body mass index, but increases in VO2peak (+3.6 vs. –0.6 ml/kg·min, P = 0.004) and oxygen pulse (+1.5 vs. +0.2 ml/bpm, P = .03) were greater in compliant than noncompliant group.Conclusions:Self-regulated exercising following CR discharge seems to be effective to maintain gains in exercise capacity acquired during supervised center-based programs.

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Anemia and the use of antihypertensive medications in hemodialysis patients: multicenter retrospective observational study

Ukrainian Journal of Nephrology and Dialysis ◽

10.31450/ukrjnd.1(61).2019.04 ◽

2019 ◽

pp. 29-38

Author(s):

N. Stepanova ◽

V. Novakivskyy ◽

L. Snisar ◽

M. Kutsenko

Keyword(s):

Observational Study ◽

Cox Regression ◽

Erythropoietin Receptor ◽

Retrospective Observational Study ◽

Antihypertensive Medications ◽

Increased Risk ◽

Interest Statement ◽

The Impact ◽

Anemia Treatment

Abstract. We hypothesized that the use of antihypertensive medications in patients treated by hemodialysis (HD) may interfere with the activity of erythropoietin and leads to an increase in the dose of erythropoiesis stimulating agents (ESAs). The aim of our study was to analyze the impact of antihypertensive medications on the effectiveness of anemia treatment. Methods. We conducted a multicenter retrospective observational study. The archival medical data from 379 patients treated by HD or hemodiafiltration (HDF) were used. The medical records of 142 patients were excluded from the study. The study group consisted of 237 patients: 108 (45.6%) women and 129 (54.4%) men, with an average age of 54 [41-62.5] years. Results. The analysis of the mean hemoglobin (Hb) stratified by the administration of antihypertensive medications in the dynamics of dialysis treatment demonstrated a significant impact of angiotensin-converting enzyme (ACE) inhibitors (F = 3.97; p = 0.048) and amlodipine (F = 6.9; p = 0.01) on the effectiveness of anemia correction. The significant effect of amlodipine on the need to increase the dosage of iron-containing medications (OR = 3.9; 95% CI (1.27-12.06), p = 0.002; RR = 1.9 95% CI (1.27-2.9) and continuous erythropoietin receptor activator (CERA) (OR = 5.2, 95% CI (1.2-24.4), p = 0.03; RR = 1.3 95% CI (1, 08-1.6), p = 0.006) weas showed by logistic regression analysis. The increased risk of failure to achieve of the target Hb level in HD patients received amlodipine was confirmed by Cox regression model (HR = 2.7 (95% CI 1.5-4.7)). Conclusions: The results of our study demonstrated a significant increase in the frequency of appointment and amount of anti-anemia therapy in HD patients when amlodipine is co-administered. Follow-up studies to determine the effect of amlodipine mechanism for anemia will avoid unreasonable prescriptions for the treatment of НD patients. Conflict of interest statement: the authors declared no competing interests.

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Twenty-Year Follow-Up of Excimer Laser Photorefractive Keratectomy: A Retrospective Observational Study

Ophthalmology and Therapy ◽

10.1007/s40123-020-00281-7 ◽

2020 ◽

Vol 9 (4) ◽

pp. 917-927

Author(s):

Giovanni Cennamo ◽

Feliciana Menna ◽

Fabrizio Sinisi ◽

Gilda Cennamo ◽

Maria Angelica Breve ◽

...

Keyword(s):

Observational Study ◽

Excimer Laser ◽

Retrospective Observational Study ◽

Photorefractive Keratectomy

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Photoreceptor morphology and correlation with subretinal fluid chronicity associated with choroidal nevus

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314755 ◽

2019 ◽

Vol 104 (6) ◽

pp. 863-867 ◽

Cited By ~ 2

Author(s):

Antonio Yaghy ◽

Michael D Yu ◽

Lauren A Dalvin ◽

Mehdi Mazloumi ◽

Sandor R Ferenczy ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Observational Study ◽

Subretinal Fluid ◽

Retrospective Observational Study ◽

Optical Coherence ◽

Progressive Change ◽

Choroidal Nevus ◽

Over Time ◽

Choroidal Nevi

BackgroundSubretinal fluid (SRF) can be associated with choroidal nevus and can cause progressive change in the morphology of overlying photoreceptors.MethodsA retrospective observational study was performed using optical coherence tomography to assess nevus and SRF features, as well as photoreceptor morphology over time.ResultsThere were 232 choroidal nevi that presented with or developed SRF. Photoreceptor morphology at presentation was classified as normal (n=60, 26%), shaggy (elongated) (n=73, 31%), retracted (stalactite appearance) (n=76, 33%), or absent (n=23, 10%). There was a progression in photoreceptor morphology with increasing SRF chronicity (p=0.003). For nevus presenting with normal photoreceptors and later developed SRF (n=60), photoreceptors became shaggy in 29 (48%), retracted in 24 (40%), and absent in 7 (12%) after 15, 19 and 22 months, respectively. For nevus presenting with SRF and shaggy photoreceptors (n=73), progression to retracted photoreceptors occurred in 31 (42%) after a mean of 22 months; for nevus with SRF and retracted photoreceptors (n=76), progression to absent photoreceptors occurred in 19 (25%) after a mean of 34 months; and for nevus with absent photoreceptors (n=23), photoreceptor morphology showed no change after mean follow-up of 33 months. Risk of nevus growth to melanoma was not associated with photoreceptor morphology at presentation (p=0.19).ConclusionIn eyes with choroidal nevus and SRF, there is a longitudinal evolution in photoreceptor morphology from normal to shaggy to retracted then absent with increasing SRF chronicity. SRF chronicity, as indicated by photoreceptor morphology on presentation, did not correlate with nevus growth to melanoma.

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