scholarly journals Evidence for improved prognosis of colorectal cancer diagnosed following the detection of iron deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Orouba Almilaji ◽  
Sally D. Parry ◽  
Sharon Docherty ◽  
Jonathon Snook
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Early Stage ◽  
Deficiency Anaemia ◽  
Logistic Regression Models ◽  
Parametric Survival Model ◽  
Bowel Cancer Screening ◽  
The Uk

AbstractIron deficiency anaemia (IDA) is common in colorectal cancer (CRC), especially, in right-sided CRC which is known to have an overall worse prognosis. The associations between diagnostic pathway (Bowel Cancer Screening Programme (BCSP), IDA, symptomatic) and tumour side/stage was assessed using logistic regression models in 1138 CRC cases presenting during 2010–2016 at a single secondary-care centre in the UK. In the IDA sub-group, the relationship between CRC stage and the event of having a blood count prior to CRC diagnosis was examined using Bayesian parametric survival model. IDA was found as the only significant predictor of right-sided CRC (OR 10.61, 95% CI 7.02–16.52). Early-stage CRC was associated with both the IDA (OR 1.65, 95% CI 1.18–2.29) and BCSP pathway (OR 2.42, 95% CI 1.75–3.37). At any age, the risk of detecting CRC at late-stage was higher in those without a previous blood count check (hazard ratio 1.53, 95% credibility interval 1.08–2.14). The findings of this retrospective observational study suggest a benefit from diagnosing CRC through the detection of IDA, and warrant further research into the prognosis benefit of systematic approach to blood count monitoring of the at-risk population.

scholarly journals Intravenous iron is non-inferior to oral iron regarding cell growth and iron metabolism in colorectal cancer associated with iron-deficiency anaemia

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hafid O. Al-Hassi ◽  
Oliver Ng ◽  
Rayko Evstatiev ◽  
Manel Mangalika ◽  
Natalie Worton ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Metabolism ◽  
Iron Deficiency Anaemia ◽  
Iron Transport ◽  
Intravenous Iron ◽  
Oral Iron ◽  
Iron Loading ◽  
Deficiency Anaemia ◽  
Iron Treatment

AbstractOral iron promotes intestinal tumourigenesis in animal models. In humans, expression of iron transport proteins are altered in colorectal cancer. This study examined whether the route of iron therapy alters iron transport and tumour growth. Colorectal adenocarcinoma patients with pre-operative iron deficiency anaemia received oral ferrous sulphate (n = 15), or intravenous ferric carboxymaltose (n = 15). Paired (normal and tumour tissues) samples were compared for expression of iron loading, iron transporters, proliferation, apoptosis and Wnt signalling using immunohistochemistry and RT-PCR. Iron loading was increased in tumour and distributed to the stroma in intravenous treatment and to the epithelium in oral treatment. Protein and mRNA expression of proliferation and iron transporters were increased in tumours compared to normal tissues but there were no significant differences between the treatment groups. However, intravenous iron treatment reduced ferritin mRNA levels in tumours and replenished body iron stores. Iron distribution to non-epithelial cells in intravenous iron suggests that iron is less bioavailable to tumour cells. Therefore, intravenous iron may be a better option in the treatment of colorectal cancer patients with iron deficiency anaemia due to its efficiency in replenishing iron levels while its effect on proliferation and iron metabolism is similar to that of oral iron treatment.

Haematology and immunology

2020 ◽  
pp. 635-662
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Nazia Hussain ◽  
Emma Nash ◽  
...  
Keyword(s):  
Immune Deficiency ◽  
General Practice ◽  
Iron Deficiency ◽  
Sedimentation Rate ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

This chapter in the Oxford Handbook of General Practice explores haematology in general practice. It covers full blood count and erythrocyte sedimentation rate. It explores diagnosis and initial investigation of anaemia, iron deficiency anaemia, haemoglobinopathies, bleeding and clotting disorders, and anticoagulation. It examines haematological malignancy, acute leukaemia, chronic leukaemia and myeloproliferation, lymphoma, immune deficiency, and allergy.

Haematology and immunology

2014 ◽  
pp. 659-686
Author(s):  
Chantal Simon ◽  
Hazel Everitt ◽  
Françoise van Dorp ◽  
Matt Burkes
Keyword(s):  
Immune Deficiency ◽  
Iron Deficiency ◽  
Acute Leukaemia ◽  
Blood Test ◽  
Iron Deficiency Anaemia ◽  
Blood Count ◽  
Full Blood Count ◽  
Deficiency Anaemia ◽  
Initial Investigation ◽  
Chronic Leukaemia

Full blood count and ESR Anaemia: diagnosis and initial investigation Iron deficiency anaemia Other anaemias Haemoglobinopathy Bleeding and clotting disorders Anticoagulation Haematological malignancy Acute leukaemia Chronic leukaemia and myeloproliferation Lymphoma Immune deficiency syndromes Allergies The most commonly requested blood test is the full blood count (FBC). It gives information on:...

Su1994 ORAL IRON THERAPY PROMOTES A PROINFLAMMATORY GUT MICROBIOTA IN COLORECTAL CANCER PATIENTS WITH IRON DEFICIENCY ANAEMIA

2020 ◽  
Vol 158 (6) ◽  
pp. S-737-S-738
Author(s):  
Oliver Phipps ◽  
Mohammed Nabil Quraishi ◽  
Aditi Kumar ◽  
Edward Dickson ◽  
Oliver Ng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Gut Microbiota ◽  
Cancer Patients ◽  
Iron Deficiency Anaemia ◽  
Oral Iron ◽  
Iron Therapy ◽  
Deficiency Anaemia ◽  
Oral Iron Therapy ◽  
Colorectal Cancer Patients

Iron-deficiency anaemia and delay in the diagnosis of colorectal cancer

2003 ◽  
Vol 5 (2) ◽  
pp. 145-148 ◽  
Author(s):  
P. L. Acher ◽  
T. Al-Mishlab ◽  
M. Rahman ◽  
T. Bates
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Iron Deficiency Anaemia ◽  
Deficiency Anaemia

scholarly journals Young-onset colorectal cancer risk among individuals with iron-deficiency anaemia and haematochezia

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321849
Author(s):  
Joshua Demb ◽  
Lin Liu ◽  
Caitlin C. Murphy ◽  
Chyke A. Doubeni ◽  
María Elena Martínez ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Iron Deficiency ◽  
Cumulative Incidence ◽  
Iron Deficiency Anaemia ◽  
Mortality Data ◽  
Veterans Health ◽  
Health Administration ◽  
Cox Models ◽  
Deficiency Anaemia ◽  
Young Onset

ObjectiveYoung-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC.DesignCohort study of US Veterans aged 18–49 years receiving Veterans Health Administration (VHA) care 1999–2016. IDA analytic cohort was created matching individuals without incident IDA to those with IDA 4:1 based on sex, birth year and first VHA visit date (n=239 000). We used this approach to also create a distinct haematochezia analytic cohort (n=653 740). Incident YCRC was ascertained via linkage to cancer registry and/or cause-specific mortality data. We computed cumulative incidence, risk difference (RD) and HRs using Cox models in each cohort.ResultsFive-year YCRC cumulative incidence was 0.45% among individuals with IDA versus 0.05% without IDA (RD: 0.39%, 95% CI: 0.33%–0.46%), corresponding to an HR of 10.81 (95% CI: 8.15–14.33). Comparing IDA versus no IDA, RD was 0.78% for men (95% CI: 0.64%–0.92%) and 0.08% for women (95% CI: 0.03%–0.13%), and RD increased by age from 0.14% for <30 years to 0.53% for 40–49 years. YCRC cumulative incidence was 0.33% among individuals with haematochezia versus 0.03% without haematochezia (RD: 0.30%, 95% CI: 0.26%–0.33%), corresponding to an HR of 10.66 (95% CI: 8.76–12.97). Comparing haematochezia versus no haematochezia, RD increased by age from 0.04% for <30 years to 0.43% for 40–49 years.ConclusionColonoscopy should be strongly considered in adults aged <50 years with IDA or haematochezia without a clinically confirmed alternate source.

Sign in / Sign up

Export Citation Format

Share Document