scholarly journals No association between alcohol consumption and pancreatic cancer even among individuals genetically susceptible to the carcinogenicity of alcohol

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yan-Shen Shan ◽  
Li-Tzong Chen ◽  
Chih-Hsing Wu ◽  
Yin-Fan Chang ◽  
Chih-Ting Lee ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Environment Interaction ◽  
Carcinogenic Effect ◽  
Pancreatic Cancer Risk ◽  
Gene Environment ◽  
Slow Activity

AbstractInconsistent results have been reported for the association between alcohol use and pancreatic cancer, particularly at low levels of alcohol consumption. Individuals genetically susceptible to the carcinogenic effect of alcohol might have higher pancreatic cancer risk after drinking alcohol. The current study investigated the association between alcohol use and pancreatic cancer with 419 pancreatic cancer cases and 963 controls recruited by a hospital-based case–control study in Taiwan. Gene-environment interaction between alcohol use and polymorphisms of two ethanol-metabolizing genes, ADH1B and ALDH2, on pancreatic risk was evaluated. Our results showed no significant association between alcohol drinking and an increased pancreatic cancer risk, even at high levels of alcohol consumption. Even among those genetically susceptible to the carcinogenic effect of alcohol (carriers of ADH1B*2/*2(fast activity) combined with ALDH2*1/*2(slow activity) or ALDH2*2/*2(almost non-functional)), no significant association between alcohol use and pancreatic cancer was observed. Overall, our results suggested that alcohol drinking is not a significant contributor to the occurrence of pancreatic cancer in Taiwan.

scholarly journals Association between Alcohol Consumption and Pancreatic Cancer Risk: A Case-Control Study

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124489 ◽  
Author(s):  
Farah Rahman ◽  
Michelle Cotterchio ◽  
Sean P. Cleary ◽  
Steven Gallinger
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Pancreatic Cancer Risk ◽  
Control Study

Tobacco smoking, alcohol consumption and pancreatic cancer risk: A case-control study in Italy

2010 ◽  
Vol 46 (2) ◽  
pp. 370-376 ◽  
Author(s):  
R. Talamini ◽  
J. Polesel ◽  
S. Gallus ◽  
L. Dal Maso ◽  
A. Zucchetto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Tobacco Smoking ◽  
Case Control Study ◽  
Case Control ◽  
Pancreatic Cancer Risk ◽  
Control Study

Breast Cancer Risk in Relation to Alcohol Consumption and BRCA Gene Mutations - A Case-Only Study of Gene-Environment Interaction

2011 ◽  
Vol 17 (5) ◽  
pp. 477-484 ◽  
Author(s):  
Jessica Dennis ◽  
Daniel Krewski ◽  
Frédérique-Sophie Côté ◽  
Eve Fafard ◽  
Julian Little ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alcohol Consumption ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Gene Mutations ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Brca Gene ◽  
Gene Environment

scholarly journals Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese

2009 ◽  
Vol 100 (2) ◽  
pp. 296-302 ◽  
Author(s):  
Junya Kanda ◽  
Keitaro Matsuo ◽  
Takeshi Suzuki ◽  
Takakazu Kawase ◽  
Akio Hiraki ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Metabolizing Enzymes ◽  
Pancreatic Cancer Risk

scholarly journals Alcohol drinking and pancreatic cancer risk: a meta-analysis of the dose-risk relation

2010 ◽  
pp. NA-NA ◽  
Author(s):  
Irene Tramacere ◽  
Lorenza Scotti ◽  
Mazda Jenab ◽  
Vincenzo Bagnardi ◽  
Rino Bellocco ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Alcohol Drinking ◽  
Meta Analysis ◽  
Pancreatic Cancer Risk

scholarly journals Association between Alcohol Consumption, Folate Intake, and Risk of Pancreatic Cancer: A Case-Control Study

2017 ◽  
Author(s):  
Winta Yellow ◽  
William R. Bamlet ◽  
Ann L. Oberg ◽  
Kristin E. Anderson ◽  
Janet E. Olson ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Case Control Study ◽  
The United States ◽  
Case Control ◽  
Folate Intake ◽  
Dietary Folate ◽  
Pancreatic Cancer Risk ◽  
Control Study

Pancreatic cancer is one of the most fatal common cancers affecting both men and women, representing about 3 percent of all new cancer cases in the United States. In this study, we aimed to investigate the association of pancreatic cancer risk with alcohol consumption as well as folate intake. We performed a case-control study of 384 patients diagnosed with pancreatic cancer from May 2004 to December 2009 and 983 primary care healthy controls. Our findings showed no significant association between risk of pancreatic cancer and either overall alcohol consumption or type of alcohol consumed (drinks/day). Our study showed dietary folate intake was modestly but significantly inversely associated with pancreatic cancer (OR=0.99, P <.0001). The current study supports the hypothesis that pancreatic cancer risk is reduced with higher food-based folate intake.

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