scholarly journals Role of the brain-derived neurotrophic factor at glutamatergic synapses

2008 ◽  
Vol 153 (S1) ◽  
pp. S310-S324 ◽  
Author(s):  
A L Carvalho ◽  
M V Caldeira ◽  
S D Santos ◽  
C B Duarte
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Glutamatergic Synapses ◽  
The Brain

Investigating the role of the brain-derived neurotrophic factor (BDNF)val66metvariant in obsessive-compulsive disorder (OCD)

2008 ◽  
Vol 9 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Sîan M.J. Hemmings ◽  
Craig J. Kinnear ◽  
Lize Van Der Merwe ◽  
Christine Lochner ◽  
Valerie A. Corfield ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
The Brain

Role of Bcl-2 in the Brain-derived Neurotrophic Factor Survival Response

1995 ◽  
Vol 7 (6) ◽  
pp. 1266-1272 ◽  
Author(s):  
Timothy E. Allsopp ◽  
Sergei Kiselev ◽  
Sean Wyatt ◽  
Alun M. Davies
Keyword(s):  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
The Brain

The brain-derived neurotrophic factor (BDNF) system as a therapeutical target for development of drugs restoring innervation

2017 ◽  
pp. 142-152
Author(s):  
Д.В. Стамбольский ◽  
О.С. Плеханова ◽  
И.Ю. Юдина ◽  
Н.И. Калинина ◽  
М.Н. Карагяур ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Current Data ◽  
Bdnf Expression ◽  
Promising Therapeutic Target ◽  
Nervous System Function ◽  
The Brain ◽  
Stimulation Of

Мозговой нейротрофический фактор (BDNF) является одним из основных нейротрофических факторов, участвующих в поддержании функционирования и регенерации нервной системы. В последние годы BDNF рассматривают как многообещающую терапевтическую мишень, на основании полученных данных о том, что BDNF улучшает регенерацию нейронов. Цель обзора - суммировать данные об экспрессии BDNF, его сигнализации, эффектах и механизмах стимуляции реиннервации. Анализ исследований последних десятилетий позволяет сделать заключение о целесообразности и перспективности разработок, направленных на создание лекарственных препаратов на основе BDNF для регенерации компонентов нервной системы. Brain-derived neurotrophic factor (BDNF) is a major neurotrophic factor maintaining the nervous system function and regeneration. Based on reports indicating that BDNF enhances neuronal regeneration, in recent years, BDNF has been considered a promising therapeutic target. The aim of this review was to summarize current data on BDNF expression, signaling, and mechanisms for stimulation of reinnervation. Conclusion. Recent studies of the role of BDNF showed that continuation of research and development of BDNF-based drugs stimulating regeneration of nervous system components is advisable and promising.

scholarly journals Conditional Deletion Of Brain-Derived Neurotrophic Factor in the Postnatal Brain Leads to Obesity and Hyperactivity

2001 ◽  
Vol 15 (10) ◽  
pp. 1748-1757 ◽  
Author(s):  
Maribel Rios ◽  
Guoping Fan ◽  
Csaba Fekete ◽  
Joseph Kelly ◽  
Brian Bates ◽  
...  
Keyword(s):  
Food Intake ◽  
Neurotrophic Factor ◽  
Elevated Serum ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Starvation Response ◽  
Conditional Deletion ◽  
Recombination System ◽  
The Brain

Abstract Brain-derived neurotrophic factor has been associated previously with the regulation of food intake. To help elucidate the role of this neurotrophin in weight regulation, we have generated conditional mutants in which brain-derived neurotrophic factor has been eliminated from the brain after birth through the use of the cre-loxP recombination system. Brain-derived neurotrophic factor conditional mutants were hyperactive after exposure to stressors and had higher levels of anxiety when evaluated in the light/dark exploration test. They also had mature onset obesity characterized by a dramatic 80–150% increase in body weight, increased linear growth, and elevated serum levels of leptin, insulin, glucose, and cholesterol. In addition, the mutants had an abnormal starvation response and elevated basal levels of POMC, an anorexigenic factor and the precursor forα -MSH. Our results demonstrate that brain derived neurotrophic factor has an essential maintenance function in the regulation of anxiety-related behavior and in food intake through central mediators in both the basal and fasted state.

scholarly journals The Role of the Val66Met Polymorphism of the Brain Derived Neurotrophic Factor Gene in Coping Strategies Relevant to Depressive Symptoms

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65547 ◽  
Author(s):  
Warren Caldwell ◽  
Opal A. McInnis ◽  
Robyn J. McQuaid ◽  
Gele Liu ◽  
John D. Stead ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Coping Strategies ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Val66met Polymorphism ◽  
Factor Gene ◽  
The Brain
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