scholarly journals Epidermal growth factor receptor-transfected bone marrow stromal cells exhibit enhanced migratory response and therapeutic potential against murine brain tumors

2005 ◽  
Vol 12 (9) ◽  
pp. 757-768 ◽  
Author(s):  
Hidemitsu Sato ◽  
Naruo Kuwashima ◽  
Tsukasa Sakaida ◽  
Manabu Hatano ◽  
Jill E Dusak ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Therapeutic Potential ◽  
Growth Factor Receptor ◽  
Marrow Stromal Cells ◽  
Migratory Response ◽  
Epidermal Growth

scholarly journals Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application?

2006 ◽  
Vol 13 (1) ◽  
pp. 3-6 ◽  
Author(s):  
Nicola Normanno ◽  
William J Gullick
Keyword(s):  
Growth Factor ◽  
Bone Metastases ◽  
Receptor Tyrosine Kinase ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Kinase Inhibitors ◽  
Growth Factor Receptor ◽  
Marrow Stromal Cells ◽  
Epidermal Growth ◽  
Egfr Tkis

The paper by Angelucci et al. published in the current issue of Endocrine-Related Cancer suggests a potential, novel application of epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of bone metastases. Interestingly, activity of anti-EGFR agents on the pathogenesis and progression of bone metastases has been described in previous reports, and a number of different mechanisms seem to be involved in this phenomenon. Anti-EGFR agents have a direct activity on tumour cells in which they produce growth inhibition, apoptosis, and reduced invasive capacity through the inhibition of molecules associated with tissue invasion such as urokinase-type plasminogen activator (uPA) and matrix metalloproteinase (MMP)-9. In addition, these compounds have an anti-angiogenic activity, either direct by affecting the proliferation and survival of endothelial cells, or indirect by blocking the production of vascular endothelial growth factor (VEGF) in bone marrow stromal cells and in tumour cells. Finally, EGFR-TKIs can inhibit recruitment of osteoclasts in bone lesions, by affecting the ability of bone marrow stromal cells to induce osteoclast differentiation and activation. Taken together, these findings strongly support prospective clinical trials of anti-EGFR agents in cancer patients with bone metastases in order to define their role in the management of bone disease.

scholarly journals Epidermal growth factor as a mechanosensitizer in human bone marrow stromal cells

2017 ◽  
Vol 24 ◽  
pp. 69-76 ◽  
Author(s):  
Sigrid Müller-Deubert ◽  
Lothar Seefried ◽  
Melanie Krug ◽  
Franz Jakob ◽  
Regina Ebert
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Epidermal Growth

Chondrogenic differentiation of bone marrow stromal cells in transforming growth factor-β1 loaded alginate bead

2005 ◽  
Vol 13 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Ki Suk Park ◽  
Chae Moon Jin ◽  
Soon Hee Kim ◽  
John M. Rhee ◽  
Gilson Khang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Chondrogenic Differentiation ◽  
Transforming Growth Factor ◽  
Alginate Bead ◽  
Transforming Growth Factor Β1 ◽  
Marrow Stromal Cells

scholarly journals Effect of Concentrated Growth Factor (CGF) on the Promotion of Osteogenesis in Bone Marrow Stromal Cells (BMSC) in vivo

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Xia Chen ◽  
Jian Wang ◽  
Li Yu ◽  
Jia Zhou ◽  
Danning Zheng ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells

scholarly journals Preparation method and growth factor content of platelet concentrate influence the osteogenic differentiation of bone marrow stromal cells

Cytotherapy ◽  
2013 ◽  
Vol 15 (7) ◽  
pp. 830-839 ◽  
Author(s):  
Francesca Perut ◽  
Giuseppe Filardo ◽  
Erminia Mariani ◽  
Annarita Cenacchi ◽  
Loredana Pratelli ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Growth Factor ◽  
Osteogenic Differentiation ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Preparation Method ◽  
Marrow Stromal Cells ◽  
Platelet Concentrate ◽  
Factor Content
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