scholarly journals Interleukin-10 gene transfer to peritoneal mesothelial cells suppresses peritoneal dissemination of gastric cancer cells due to a persistently high concentration in the peritoneal cavity

2007 ◽  
Vol 15 (1) ◽  
pp. 51-59 ◽  
Author(s):  
F Tanaka ◽  
K Tominaga ◽  
M Shiota ◽  
M Ochi ◽  
H Kuwamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Transfer ◽  
Cancer Cells ◽  
Peritoneal Cavity ◽  
Peritoneal Dissemination ◽  
Interleukin 10 ◽  
Mesothelial Cells ◽  
High Concentration ◽  
Gastric Cancer Cells ◽  
Peritoneal Mesothelial Cells

Tumor-associated mesothelial cells are negative prognostic factors in gastric cancer and promote peritoneal dissemination of adherent gastric cancer cells by chemotaxis

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 6105-6111 ◽  
Author(s):  
Zhi-Feng Miao ◽  
Ting-Ting Zhao ◽  
Zhen-Ning Wang ◽  
Feng Miao ◽  
Ying-Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Factors ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Mesothelial Cells ◽  
Gastric Cancer Cells

scholarly journals Extracellular vesicles shed from gastric cancer mediate protumor macrophage differentiation

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Atene Ito ◽  
Shunsuke Kagawa ◽  
Shuichi Sakamoto ◽  
Kazuya Kuwada ◽  
Hiroki Kajioka ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Ascitic Fluid ◽  
Extracellular Vesicles ◽  
Peritoneal Cavity ◽  
Peritoneal Dissemination ◽  
Tumor Associated Macrophages ◽  
Gastric Cancer Cells ◽  
Gastric Cancer Patients

Abstract Background Peritoneal dissemination often develops in gastric cancer. Tumor-associated macrophages (TAMs) are present in the peritoneal cavity of gastric cancer patients with peritoneal dissemination, facilitating tumor progression. However, the mechanism by which macrophages differentiate into tumor-associated macrophages in the peritoneal cavity is not well understood. In this study, the interplay between gastric cancer-derived extracellular vesicles (EVs) and macrophages was investigated. Methods The association between macrophages and EVs in peritoneal ascitic fluid of gastric cancer patients, or from gastric cancer cell lines was examined, and their roles in differentiation of macrophages and potentiation of the malignancy of gastric cancer were further explored. Results Immunofluorescent assays of the ascitic fluid showed that M2 macrophages were predominant along with the cancer cells in the peritoneal cavity. EVs purified from gastric cancer cells, as well as malignant ascitic fluid, differentiated peripheral blood mononuclear cell-derived macrophages into the M2-like phenotype, which was demonstrated by their morphology and expression of CD163/206. The macrophages differentiated by gastric cancer-derived EVs promoted the migration ability of gastric cancer cells, and the EVs carried STAT3 protein. Conclusion EVs derived from gastric cancer play a role by affecting macrophage phenotypes, suggesting that this may be a part of the underlying mechanism that forms the intraperitoneal cancer microenvironment.

Abstract 5169: Omics approach to identify driver genes for peritoneal dissemination of gastric cancer cells

2015 ◽  
Author(s):  
Sho Nambara ◽  
Junji Kurashige ◽  
Tomoko Saito ◽  
Hisateru Komatsu ◽  
Masami Ueda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Gastric Cancer Cells ◽  
Driver Genes

scholarly journals Elevated Expression of Cyr61 Enhances Peritoneal Dissemination of Gastric Cancer Cells through Integrin α2β1

2007 ◽  
Vol 282 (47) ◽  
pp. 34594-34604 ◽  
Author(s):  
Ming-Tsan Lin ◽  
Cheng-Chi Chang ◽  
Been-Ren Lin ◽  
Hsin-Yu Yang ◽  
Chia-Yu Chu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Gastric Cancer Cells ◽  
Elevated Expression

scholarly journals Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells

Oncogene ◽  
1998 ◽  
Vol 16 (20) ◽  
pp. 2681-2686 ◽  
Author(s):  
Atsushi Yawata ◽  
Masaaki Adachi ◽  
Hiroyuki Okuda ◽  
Yasuyoshi Naishiro ◽  
Takenori Takamura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Survival ◽  
Cancer Cells ◽  
Peritoneal Dissemination ◽  
Gastric Cancer Cells
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