In a rat model of transient ischemia, acute albumin leakage across the blood-brain barrier is often followed by rapid cellular uptake

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S277-S277
Author(s):  
Tavarekere N Nagaraja ◽  
Kelly A Keenan ◽  
Joseph D Fenstermacher ◽  
Robert A Knight
Keyword(s):  
Blood Brain Barrier ◽  
Cellular Uptake ◽  
Rat Model ◽  
Brain Barrier ◽  
Transient Ischemia ◽  
Blood Brain ◽  
Albumin Leakage

scholarly journals Blood-brain barrier disruption and angiogenesis in a rat model for neurocysticercosis

2018 ◽  
Vol 97 (2) ◽  
pp. 137-148 ◽  
Author(s):  
Rogger P. Carmen-Orozco ◽  
Danitza G. Dávila-Villacorta ◽  
Yudith Cauna ◽  
Edson G. Bernal-Teran ◽  
Leandra Bitterfeld ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

scholarly journals The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Beatrice Formicola ◽  
Roberta Dal Magro ◽  
Carlos V. Montefusco-Pereira ◽  
Claus-Michael Lehr ◽  
Marcus Koch ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Blood Brain Barrier ◽  
Cellular Uptake ◽  
Brain Barrier ◽  
Synergistic Activity ◽  
Anti Tumour Activity ◽  
Blood Brain ◽  
Tumour Activity

Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.

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