scholarly journals Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

Oncogene ◽  
1998 ◽  
Vol 17 (25) ◽  
pp. 3365-3383 ◽  
Author(s):  
Xavier Graña ◽  
Judit Garriga ◽  
Xavier Mayol
Keyword(s):  
Cell Growth ◽  
Retinoblastoma Protein ◽  
Negative Control ◽  
Protein Family

scholarly journals Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation

Cell Cycle ◽  
2015 ◽  
Vol 14 (4) ◽  
pp. 589-597 ◽  
Author(s):  
Jared S Elenbaas ◽  
Rima Mouawad ◽  
R William Henry ◽  
David N Arnosti ◽  
Sandhya Payankaulam
Keyword(s):  
Cell Growth ◽  
Retinoblastoma Protein ◽  
Protein Instability ◽  
Cell Growth And Proliferation

Knockout of Ajuba Attenuates the Growth and Migration of Hepatocellular Carcinoma Cells

2020 ◽  
Vol 160 (11-12) ◽  
pp. 650-658
Author(s):  
Yichen Le ◽  
Yi He ◽  
Meirong Bai ◽  
Ying Wang ◽  
Jiaxue Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Cancer Progression ◽  
Normal Liver ◽  
Cell Growth And Migration ◽  
And Migration ◽  
Hcc Cells

Ajuba has been found to be mutated or aberrantly regulated in several human cancers and plays important roles in cancer progression via different signaling pathways. However, little is known about the role of Ajuba in hepatocellular carcinoma (HCC). Here, we found an upregulation of Ajuba expression in HCC tissues compared with normal liver tissues, while a poor prognosis was observed in HCC patients with high Ajuba expression. Knockout of Ajuba in HCC cells inhibited cell growth in vitro and in vivo, suppressed cell migration, and enhanced the cell apoptosis under stress. Moreover, re-expression of Ajuba in Ajuba-deficient cells could restore the phenotype of Ajuba-deficient cells. In conclusion, these results indicate that Ajuba is upregulated in HCC and promotes cell growth and migration of HCC cells, suggesting that Ajuba could possibly be a new target for HCC diagnosis and treatment.

ROLE OF IgD IN TOLERANCE AND CROSS-PRIMING: IgD-RELATED SIGNALS IN B-CELL GROWTH, DIFFERENTIATION AND TOLERANCE

1982 ◽  
Vol 399 (1 Immunoglobuli) ◽  
pp. 290-295
Author(s):  
David W. Scott ◽  
Jane Tuttle ◽  
P. S. Pillai ◽  
Margaret Piper
Keyword(s):  
Cell Growth ◽  
B Cell

The role of the Bcl-2 protein family in tumorigenesis and cancer therapy

2013 ◽  
Vol 41 (8) ◽  
pp. S9
Author(s):  
Andreas Strasser ◽  
G. Kelly ◽  
S. Glaser ◽  
P.N. Kelly ◽  
S. Grabow ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Protein Family

An oligomer complementary to c-myc mRNA inhibits proliferation of HL-60 promyelocytic cells and induces differentiation

1988 ◽  
Vol 8 (2) ◽  
pp. 963-973
Author(s):  
J T Holt ◽  
R L Redner ◽  
A W Nienhuis
Keyword(s):  
Cell Growth ◽  
Protein Concentration ◽  
Myeloid Differentiation ◽  
Sequence Specificity ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Steady State Levels ◽  
Cell Growth And Differentiation ◽  
Antisense Oligomer

To study the role of a nuclear proto-oncogene in the regulation of cell growth and differentiation, we inhibited HL-60 c-myc expression with a complementary antisense oligomer. This oligomer was stable in culture and entered cells, forming an intracellular duplex. Incubation of cells with the anti-myc oligomer decreased the steady-state levels of c-myc protein by 50 to 80%, whereas a control oligomer did not significantly affect the c-myc protein concentration. Direct inhibition of c-myc expression with the anti-myc oligomer was associated with a decreased cell growth rate and an induction of myeloid differentiation. Related antisense oligomers with 2- to 12-base-pair mismatches with c-myc mRNA did not influence HL-60 cells. Thus, the effects of the antisense oligomer exhibited sequence specificity, and furthermore, these effects could be reversed by hybridization competition with another complementary oligomer. Antisense inhibition of a nuclear proto-oncogene apparently bypasses cell surface events in affecting cell proliferation and differentiation.

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