scholarly journals Migrating Oligodendrocyte Progenitor Cells Swell Prior to Soma Dislocation

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Patrick Happel ◽  
Kerstin Möller ◽  
Nina K. Schwering ◽  
Irmgard D. Dietzel
Keyword(s):  
Progenitor Cells ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor

Developmental trajectory of oligodendrocyte progenitor cells in the human brain revealed by single cell RNA sequencing

Glia ◽  
2020 ◽  
Vol 68 (6) ◽  
pp. 1291-1303 ◽  
Author(s):  
Kelly Perlman ◽  
Charles P. Couturier ◽  
Moein Yaqubi ◽  
Arnaud Tanti ◽  
Qiao‐Ling Cui ◽  
...  
Keyword(s):  
Human Brain ◽  
Single Cell ◽  
Progenitor Cells ◽  
Rna Sequencing ◽  
Developmental Trajectory ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Single Cell Rna Sequencing

Antipsychotics promote the differentiation of oligodendrocyte progenitor cells by regulating oligodendrocyte lineage transcription factors 1 and 2

Life Sciences ◽  
2013 ◽  
Vol 93 (12-14) ◽  
pp. 429-434 ◽  
Author(s):  
Fang Fang ◽  
Handi Zhang ◽  
Yanbo Zhang ◽  
Haiyun Xu ◽  
Qingjun Huang ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Progenitor Cells ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor

Hemoglobin induces oxidative stress and mitochondrial dysfunction in oligodendrocyte progenitor cells

2021 ◽  
Author(s):  
Chirayu D. Pandya ◽  
Hemendra Vekaria ◽  
Binoy Joseph ◽  
Stacey A. Slone ◽  
John C. Gensel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Progenitor Cells ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor

scholarly journals Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood–Brain Barrier

2013 ◽  
Vol 74 (4) ◽  
pp. 1011-1021 ◽  
Author(s):  
Yujie Huang ◽  
Caitlin Hoffman ◽  
Prajwal Rajappa ◽  
Joon-Hyung Kim ◽  
Wenhuo Hu ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Blood Brain

scholarly journals The Divalent Metal Transporter 1 (DMT1) Is Required for Iron Uptake and Normal Development of Oligodendrocyte Progenitor Cells

2018 ◽  
Vol 38 (43) ◽  
pp. 9142-9159 ◽  
Author(s):  
Veronica T. Cheli ◽  
Diara A. Santiago González ◽  
Leandro N. Marziali ◽  
Norma N. Zamora ◽  
María E. Guitart ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Iron Uptake ◽  
Normal Development ◽  
Divalent Metal ◽  
Oligodendrocyte Progenitor Cells ◽  
Divalent Metal Transporter 1 ◽  
Oligodendrocyte Progenitor ◽  
Divalent Metal Transporter ◽  
Metal Transporter

Co-Ultramicronized Palmitoylethanolamide/Luteolin Facilitates the Development of Differentiating and Undifferentiated Rat Oligodendrocyte Progenitor Cells

2017 ◽  
Vol 55 (1) ◽  
pp. 103-114 ◽  
Author(s):  
Stephen D. Skaper ◽  
Massimo Barbierato ◽  
Laura Facci ◽  
Mila Borri ◽  
Gabriella Contarini ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Ultramicronized Palmitoylethanolamide

scholarly journals A Novel Pharmacogenetic Model for Highly Efficient Ablation of Oligodendrocyte Progenitor Cells in the Adult Mouse CNS

2021 ◽  
Author(s):  
Yao Lulu Xing ◽  
Bernard H.A. Chuang ◽  
Jasmine Poh ◽  
Kaveh Moradi ◽  
Stanislaw Mitew ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Adult Mouse ◽  
Oligodendrocyte Progenitor Cells ◽  
Oligodendrocyte Progenitor ◽  
Cell Ablation ◽  
Novel Approach ◽  
Anterior Forebrain ◽  
Health And Disease ◽  
The Brain ◽  
Advance Knowledge

Approaches to investigate adult oligodendrocyte progenitor cells (OPCs) by targeted cell ablation in the rodent central nervous system have been limited by methodological challenges resulting in only partial and transient OPC depletion. We have developed a novel pharmacogenetic model of conditional OPC ablation, resulting in the elimination of 99.7% of all OPCs throughout the brain. By combining recombinase-based transgenic and viral strategies for targeting of OPCs and ventricular-subventricular zone (V-SVZ)-derived neural precursor cells (NPCs), we found that new PDGFRα-expressing cells born in the V-SVZ repopulated the OPC-deficient brain starting 12 days after OPC ablation. Our data reveal that OPC depletion induces V-SVZ-derived NPCs to generate vast numbers of PDGFRα+/NG2+ cells with the capacity to migrate and proliferate extensively throughout the dorsal anterior forebrain. Further application of this novel approach to ablate OPCs will advance knowledge of the function of both OPCs and oligodendrogenic NPCs in health and disease.

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