scholarly journals Enhancer of rudimentary homolog regulates DNA damage response in hepatocellular carcinoma

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Meng-Tzu Weng ◽  
Tzu-Hsun Tung ◽  
Jih-Hsiang Lee ◽  
Shu-Chen Wei ◽  
Hang-Li Lin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Damage Response ◽  
Enhancer Of Rudimentary

THU-447-DNA damage response CHK2 activates senescence cellular program and supports oxidative metabolism to drive hepatocellular carcinoma development

2019 ◽  
Vol 70 (1) ◽  
pp. e355
Author(s):  
Matteo Lulli ◽  
Lorenzo Cavallini ◽  
Laura Gragnani ◽  
Caecilia Sukowati ◽  
Tommaso Mello ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Oxidative Metabolism ◽  
Damage Response

The Relationship Between Single-Nucleotide Polymorphisms, the Expression of DNA Damage Response Genes, and Hepatocellular Carcinoma in a Polish Population

2017 ◽  
Vol 36 (8) ◽  
pp. 693-708 ◽  
Author(s):  
Renata Krupa ◽  
Piotr Czarny ◽  
Paulina Wigner ◽  
Joanna Wozny ◽  
Maciej Jablkowski ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Single Nucleotide Polymorphisms ◽  
Dna Damage Response ◽  
Polish Population ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Damage Response ◽  
The Relationship

scholarly journals An indolylquinoline derivative activates DNA damage response and apoptosis in human hepatocellular carcinoma cells

2016 ◽  
Vol 49 (6) ◽  
pp. 2431-2441 ◽  
Author(s):  
Chun-Yen Liu ◽  
Chang-Hung Hsieh ◽  
Seung-Hun Kim ◽  
Jing-Ping Wang ◽  
Yu-Lin Ni ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Damage Response ◽  
Human Hepatocellular Carcinoma Cells

ARID2 modulates DNA damage response in human hepatocellular carcinoma cells

2017 ◽  
Vol 66 (5) ◽  
pp. 942-951 ◽  
Author(s):  
Atsushi Oba ◽  
Shu Shimada ◽  
Yoshimitsu Akiyama ◽  
Taketo Nishikawaji ◽  
Kaoru Mogushi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Carcinoma Cells ◽  
Human Hepatocellular Carcinoma ◽  
Hepatocellular Carcinoma Cells ◽  
Damage Response ◽  
Human Hepatocellular Carcinoma Cells

DNA damage response protein checkpoint kinase 2 (CHK2) links chromosomal instability to cellular metabolism in hepatocellular carcinoma (HCC)

2020 ◽  
Vol 73 ◽  
pp. S639-S640
Author(s):  
Matteo Lulli ◽  
Veronica Ghini ◽  
Tommaso Mello ◽  
Caecilia Sukowati ◽  
Antonio Mazzocca ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Chromosomal Instability ◽  
Cellular Metabolism ◽  
Checkpoint Kinase ◽  
Damage Response ◽  
Checkpoint Kinase 2

scholarly journals Involvement of DNA Damage Response Pathways in Hepatocellular Carcinoma

2014 ◽  
Vol 2014 ◽  
pp. 1-18 ◽  
Author(s):  
Sheau-Fang Yang ◽  
Chien-Wei Chang ◽  
Ren-Jie Wei ◽  
Yow-Ling Shiue ◽  
Shen-Nien Wang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Genetic Alterations ◽  
Dna Lesions ◽  
Cell Cycle Checkpoints ◽  
Dna Damages ◽  
Damage Response ◽  
Associated Risk Factors

Hepatocellular carcinoma (HCC) has been known as one of the most lethal human malignancies, due to the difficulty of early detection, chemoresistance, and radioresistance, and is characterized by active angiogenesis and metastasis, which account for rapid recurrence and poor survival. Its development has been closely associated with multiple risk factors, including hepatitis B and C virus infection, alcohol consumption, obesity, and diet contamination. Genetic alterations and genomic instability, probably resulted from unrepaired DNA lesions, are increasingly recognized as a common feature of human HCC. Dysregulation of DNA damage repair and signaling to cell cycle checkpoints, known as the DNA damage response (DDR), is associated with a predisposition to cancer and affects responses to DNA-damaging anticancer therapy. It has been demonstrated that various HCC-associated risk factors are able to promote DNA damages, formation of DNA adducts, and chromosomal aberrations. Hence, alterations in the DDR pathways may accumulate these lesions to trigger hepatocarcinogenesis and also to facilitate advanced HCC progression. This review collects some of the most known information about the link between HCC-associated risk factors and DDR pathways in HCC. Hopefully, the review will remind the researchers and clinicians of further characterizing and validating the roles of these DDR pathways in HCC.

Promoter hypermethylation of DNA damage response genes in hepatocellular carcinoma

2012 ◽  
Vol 36 (5) ◽  
pp. 427-432 ◽  
Author(s):  
Zhiqin Li ◽  
Hongyan Zhang ◽  
Jianping Yang ◽  
Tielai Hao ◽  
Shenglei Li
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Promoter Hypermethylation ◽  
Damage Response
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