scholarly journals Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Bharath Chelluboina ◽  
Aditi Warhekar ◽  
Matt Dillard ◽  
Jeffrey D. Klopfenstein ◽  
David M. Pinson ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Matrix Metalloproteinase ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Transcriptional Inactivation ◽  
Matrix Metalloproteinase 12

Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia

2012 ◽  
Vol 689 (1-3) ◽  
pp. 89-95 ◽  
Author(s):  
Kyungjin Lee ◽  
Jeong-Sook Lee ◽  
Hyeung-Jin Jang ◽  
Sung-Moo Kim ◽  
Mun Seog Chang ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Matrix Metalloproteinase ◽  
Chlorogenic Acid ◽  
Brain Damage ◽  
Rat Model ◽  
Focal Cerebral Ischemia ◽  
Matrix Metalloproteinase 2

scholarly journals Matrix Metalloproteinase-12 Induces Blood–Brain Barrier Damage After Focal Cerebral Ischemia

Stroke ◽  
2015 ◽  
Vol 46 (12) ◽  
pp. 3523-3531 ◽  
Author(s):  
Bharath Chelluboina ◽  
Jeffrey D. Klopfenstein ◽  
David M. Pinson ◽  
David Z. Wang ◽  
Raghu Vemuganti ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Matrix Metalloproteinase ◽  
Blood Brain Barrier ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Blood Brain ◽  
Blood Brain Barrier Damage ◽  
Matrix Metalloproteinase 12

PPAR-γ agonist rosiglitazone decreases focal cerebral ischemia-induced inflammation and brain damage in adult mice

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S94-S94
Author(s):  
Kudret Tureyen ◽  
Ramya Sundaresan ◽  
Kellie Bowen ◽  
Raghu Vemuganti
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Adult Mice ◽  
Ppar Γ

scholarly journals Zingiber officinaleMitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Jintanaporn Wattanathorn ◽  
Jinatta Jittiwat ◽  
Terdthai Tongun ◽  
Supaporn Muchimapura ◽  
Kornkanok Ingkaninan
Keyword(s):  
Cognitive Function ◽  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Infarct Volume ◽  
Neuroprotective Effect ◽  
Morris Water Maze Test ◽  
Brain Infarct ◽  
Ginger Rhizome ◽  
The Brain

Cerebral ischemia is known to produce brain damage and related behavioral deficits including memory. Recently, accumulating lines of evidence showed that dietary enrichment with nutritional antioxidants could reduce brain damage and improve cognitive function. In this study, possible protective effect ofZingiber officinale, a medicinal plant reputed for neuroprotective effect against oxidative stress-related brain damage, on brain damage and memory deficit induced by focal cerebral ischemia was elucidated. Male adult Wistar rats were administrated an alcoholic extract of ginger rhizome orally 14 days before and 21 days after the permanent occlusion of right middle cerebral artery (MCAO). Cognitive function assessment was performed at 7, 14, and 21 days after MCAO using the Morris water maze test. The brain infarct volume and density of neurons in hippocampus were also determined. Furthermore, the level of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in cerebral cortex, striatum, and hippocampus was also quantified at the end of experiment. The results showed that cognitive function and neurons density in hippocampus of rats receiving ginger rhizome extract were improved while the brain infarct volume was decreased. The cognitive enhancing effect and neuroprotective effect occurred partly via the antioxidant activity of the extract. In conclusion, our study demonstrated the beneficial effect of ginger rhizome to protect against focal cerebral ischemia.

Mechanisms of brain damage in focal cerebral ischemia

1988 ◽  
Vol 77 (2) ◽  
pp. 81-101 ◽  
Author(s):  
M. Nedergaard
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia

scholarly journals Serial Semiquantitative Imaging of Brain Damage Using Micro-SPECT and Micro-CT After Endothelin-1-Induced Transient Focal Cerebral Ischemia in Rats

2011 ◽  
Vol 52 (12) ◽  
pp. 1987-1992 ◽  
Author(s):  
A.-G. Ceulemans ◽  
S. Hernot ◽  
T. Zgavc ◽  
V. Caveliers ◽  
S. Hachimi-Idrissi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Focal Cerebral Ischemia ◽  
Micro Ct ◽  
Endothelin 1 ◽  
Transient Focal Cerebral Ischemia

scholarly journals Leukocyte-Endothelium Interactions during Permanent Focal Cerebral Ischemia in Mice

2004 ◽  
Vol 24 (6) ◽  
pp. 668-676 ◽  
Author(s):  
Hiroharu Kataoka ◽  
Seong-Woong Kim ◽  
Nikolaus Plesnila
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Molecular Mechanisms ◽  
Focal Cerebral Ischemia ◽  
Fluorescent Microscopy ◽  
Capillary Density ◽  
Artery Occlusion ◽  
Cerebral Artery Occlusion ◽  
Adherent Leukocytes

The contribution of leukocyte infiltration to brain damage after permanent focal cerebral ischemia and the underlying molecular mechanisms are still unclear. Therefore, the aim of this study was to establish a mouse model for the visualization of leukocytes in the cerebral microcirculation in vivo and to investigate leukocyte-endothelial interaction (LEI) after permanent middle cerebral artery occlusion (MCAO). Sham-operated 129/Sv mice showed physiologic LEI in pial venules as observed by intravital fluorescent microscopy. Permanent focal cerebral ischemia induced a significant increase of LEI predominantly in pial venules. The number of rolling and adherent leukocytes reached 36.5 ± 13.2/100 μm × min and 22.5 ± 7.9/100 μm × min, respectively at 120 minutes after MCAO ( P = 0.016 vs. control). Of note, rolling and adherent leukocytes were also observed in arterioles of ischemic animals (7.3 ± 3.0/100 μm × min rolling and 3.0 ± 3.6/100 μm × min adherent). Capillary density was not different between groups. These results demonstrate that leukocytes accumulate in the brain not only after transient but also after permanent focal cerebral ischemia and may therefore contribute to brain damage after stroke without reperfusion.

The effect of oxygen therapy on brain damage and cerebral pO2in transient focal cerebral ischemia in the rat

2007 ◽  
Vol 28 (8) ◽  
pp. 963-976 ◽  
Author(s):  
Huagang Hou ◽  
Oleg Grinberg ◽  
Benjamin Williams ◽  
Stalina Grinberg ◽  
Hongsheng Yu ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Brain Damage ◽  
Oxygen Therapy ◽  
Focal Cerebral Ischemia ◽  
Transient Focal Cerebral Ischemia ◽  
Effect Of Oxygen
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